现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2015年
11期
1544-1546
,共3页
聂娜%宋杨%杨静%郑蕾%冯英明%苏海川
聶娜%宋楊%楊靜%鄭蕾%馮英明%囌海川
섭나%송양%양정%정뢰%풍영명%소해천
Ese-3%结肠癌%免疫组织化学
Ese-3%結腸癌%免疫組織化學
Ese-3%결장암%면역조직화학
Ese-3%colorectal cancer%immunohistochemistry
目的:探讨上皮转录调控因子-3(epithelium-specific Ets transcription factor-3,Ese-3)在结肠癌组织中的表达及与临床病理特征之间的关系。方法:采用免疫组化SP法检测76例结肠癌组织及癌旁组织标本中Ese-3的表达,分析其表达与患者临床病理特征之间的关系。结果:Ese-3表达于细胞核中。Ese-3蛋白在癌旁正常组织中的表达明显高于相应结肠癌中的表达。在结肠癌组织中Ese-3表达与病理分期( p
目的:探討上皮轉錄調控因子-3(epithelium-specific Ets transcription factor-3,Ese-3)在結腸癌組織中的錶達及與臨床病理特徵之間的關繫。方法:採用免疫組化SP法檢測76例結腸癌組織及癌徬組織標本中Ese-3的錶達,分析其錶達與患者臨床病理特徵之間的關繫。結果:Ese-3錶達于細胞覈中。Ese-3蛋白在癌徬正常組織中的錶達明顯高于相應結腸癌中的錶達。在結腸癌組織中Ese-3錶達與病理分期( p
목적:탐토상피전록조공인자-3(epithelium-specific Ets transcription factor-3,Ese-3)재결장암조직중적표체급여림상병리특정지간적관계。방법:채용면역조화SP법검측76례결장암조직급암방조직표본중Ese-3적표체,분석기표체여환자림상병리특정지간적관계。결과:Ese-3표체우세포핵중。Ese-3단백재암방정상조직중적표체명현고우상응결장암중적표체。재결장암조직중Ese-3표체여병리분기( p
Objective:To explore the expression of Ese-3 and the relation between Ese-3 expression and clini-cal pathological features in human colorectal cancer. Methods:Using immunohistochemical technique,we detected the expression of Ese-3 in tumor tissue and para-tumor tissue in 76 patients with colorectal cancer. The correlation be-tween Ese-3 expression and clinical pathological features was analyzed. Results:We found that Ese-3 protein was expressed in the nucleus. Ese-3 protein expression in para-tumor tissue was significantly higher than tumor tissue in human colorectal cancer. Expression of Ese-3 was associated with clinical TNM stage and tumor differentiation de-gree(p﹤0. 05). Conclusion:The reduced expression of Ese-3 in tumor tissues may play an important role in the occurrence and development of human colorectal cancer.