现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2015年
11期
1539-1543
,共5页
许英艺%张雅雅%林智才%陈玉强%卢伟锋
許英藝%張雅雅%林智纔%陳玉彊%盧偉鋒
허영예%장아아%림지재%진옥강%로위봉
骨桥蛋白%胃肿瘤%Meta分析
骨橋蛋白%胃腫瘤%Meta分析
골교단백%위종류%Meta분석
osteopontin expression%stomach neoplasms%Meta-analysis
目的:系统评价国内有关胃癌组织中OPN表达及临床意义的研究。方法:检索CBM、CNKI、VIP和万方数据库,并辅以文献追溯的方法,收集公开发表的所有关于胃癌组织中OPN表达及其与临床病理特征关系的病例对照研究。检索年限均为从建库至2014年8月20日。按纳入排除标准筛选文献并评价纳入研究质量后,应用RevMan 5.2软件进行Meta分析。结果:共纳入9个病例对照研究,其中胃癌组585例,对照组153例。Meta分析结果显示:OPN在胃癌组与对照组[ OR=0.04,95%CI(0.02,0.07)]、高中分化组与低分化组[OR=0.55,95%CI(0.34,0.89)]、临床Ⅰ-Ⅱ期组与临床Ⅲ-Ⅳ期组[OR=0.20,95%CI(0.10,0.38)]、有淋巴结转移组与无淋巴结转移组[ OR=3.24,95%CI(1.26,8.33)]的表达差异均有统计学意义。结论:目前国内证据证明,OPN可能参与了胃癌发生、发展的全过程,检测OPN表达有助于判断胃癌患者的预后。
目的:繫統評價國內有關胃癌組織中OPN錶達及臨床意義的研究。方法:檢索CBM、CNKI、VIP和萬方數據庫,併輔以文獻追溯的方法,收集公開髮錶的所有關于胃癌組織中OPN錶達及其與臨床病理特徵關繫的病例對照研究。檢索年限均為從建庫至2014年8月20日。按納入排除標準篩選文獻併評價納入研究質量後,應用RevMan 5.2軟件進行Meta分析。結果:共納入9箇病例對照研究,其中胃癌組585例,對照組153例。Meta分析結果顯示:OPN在胃癌組與對照組[ OR=0.04,95%CI(0.02,0.07)]、高中分化組與低分化組[OR=0.55,95%CI(0.34,0.89)]、臨床Ⅰ-Ⅱ期組與臨床Ⅲ-Ⅳ期組[OR=0.20,95%CI(0.10,0.38)]、有淋巴結轉移組與無淋巴結轉移組[ OR=3.24,95%CI(1.26,8.33)]的錶達差異均有統計學意義。結論:目前國內證據證明,OPN可能參與瞭胃癌髮生、髮展的全過程,檢測OPN錶達有助于判斷胃癌患者的預後。
목적:계통평개국내유관위암조직중OPN표체급림상의의적연구。방법:검색CBM、CNKI、VIP화만방수거고,병보이문헌추소적방법,수집공개발표적소유관우위암조직중OPN표체급기여림상병리특정관계적병례대조연구。검색년한균위종건고지2014년8월20일。안납입배제표준사선문헌병평개납입연구질량후,응용RevMan 5.2연건진행Meta분석。결과:공납입9개병례대조연구,기중위암조585례,대조조153례。Meta분석결과현시:OPN재위암조여대조조[ OR=0.04,95%CI(0.02,0.07)]、고중분화조여저분화조[OR=0.55,95%CI(0.34,0.89)]、림상Ⅰ-Ⅱ기조여림상Ⅲ-Ⅳ기조[OR=0.20,95%CI(0.10,0.38)]、유림파결전이조여무림파결전이조[ OR=3.24,95%CI(1.26,8.33)]적표체차이균유통계학의의。결론:목전국내증거증명,OPN가능삼여료위암발생、발전적전과정,검측OPN표체유조우판단위암환자적예후。
Objective:To investigate the expression and clinical significance of osteopontin( OPN ) in gastric cancer with Meta-analyses. Methods:The published studies were searched in the CBM,CNKI,VIP and WanFang databases,and other relevant journals were also handsearched to identify all the relevant case -control trials. The quality of the included studies was assessed. The Cochrane Collaborationˊs software RevMan 5. 2 was used to test the heterogeneity,overall effect and publication bias of the combined studies. Results:A total of 9 studies were recruited. The positive of OPN in gastric cancer was significantly higher than this in control group tissues with OR(95%CI)at 0. 04(0. 02,0. 07). The level of OPN expression had a positive correlation with the histological grading,clinical stages with OR(95%CI),lymph node metastasis,at 0. 55(0. 34,0. 89),0. 20(0. 10,0. 38),3. 24(1. 26,8. 33),respective-ly. Conclusion:ccording to the domestic evidence,OPN may be participate the whole course of carcinogenesis of gas-tric cancer,and may be useful predicting the prognosis of gastric cancer.