现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2015年
11期
1515-1517
,共3页
分化型甲状腺癌%抗甲状腺球蛋白抗体%甲状腺球蛋白
分化型甲狀腺癌%抗甲狀腺毬蛋白抗體%甲狀腺毬蛋白
분화형갑상선암%항갑상선구단백항체%갑상선구단백
differentiated thyroid carcinoma%antithyroglobulin antibody%thyroglobulin
目的：探讨血清TgAb（抗甲状腺球蛋白抗体）水平对预测DTC（分化型甲状腺癌）术后转移/复发的临床价值。方法：选择50例血清Tg（甲状腺球蛋白）阴性、TgAb阳性的DTC术后患者，将其分为转移/复发组（M组）35例和无转移/复发组（N组）15例，观察其TgAb水平；根据TgAb水平分为低水平组（100-2000IU/ml）和高水平组（﹥2000IU/ml），研究TgAb不同水平组DTC患者的转移率、转移部位。结果：转移/复发组TgAb值明显高于无转移/复发组，两组TgAb值分布差别显著（ u＝120.500，p＝0.002）。血清TgAb高水平组转移率明显高于低水平组，两组转移率差别显著（ p＝0.011），进一步分析，高水平组发生淋巴结、肺转移高于低水平组，有明显统计学差异（ p﹤0.05）。结论：血清Tg阴性时，TgAb可作为DTC术后转移/复发的监测指标。TgAb值越高，发生转移/复发可能性越大。
目的：探討血清TgAb（抗甲狀腺毬蛋白抗體）水平對預測DTC（分化型甲狀腺癌）術後轉移/複髮的臨床價值。方法：選擇50例血清Tg（甲狀腺毬蛋白）陰性、TgAb暘性的DTC術後患者，將其分為轉移/複髮組（M組）35例和無轉移/複髮組（N組）15例，觀察其TgAb水平；根據TgAb水平分為低水平組（100-2000IU/ml）和高水平組（﹥2000IU/ml），研究TgAb不同水平組DTC患者的轉移率、轉移部位。結果：轉移/複髮組TgAb值明顯高于無轉移/複髮組，兩組TgAb值分佈差彆顯著（ u＝120.500，p＝0.002）。血清TgAb高水平組轉移率明顯高于低水平組，兩組轉移率差彆顯著（ p＝0.011），進一步分析，高水平組髮生淋巴結、肺轉移高于低水平組，有明顯統計學差異（ p﹤0.05）。結論：血清Tg陰性時，TgAb可作為DTC術後轉移/複髮的鑑測指標。TgAb值越高，髮生轉移/複髮可能性越大。
목적：탐토혈청TgAb（항갑상선구단백항체）수평대예측DTC（분화형갑상선암）술후전이/복발적림상개치。방법：선택50례혈청Tg（갑상선구단백）음성、TgAb양성적DTC술후환자，장기분위전이/복발조（M조）35례화무전이/복발조（N조）15례，관찰기TgAb수평；근거TgAb수평분위저수평조（100-2000IU/ml）화고수평조（﹥2000IU/ml），연구TgAb불동수평조DTC환자적전이솔、전이부위。결과：전이/복발조TgAb치명현고우무전이/복발조，량조TgAb치분포차별현저（ u＝120.500，p＝0.002）。혈청TgAb고수평조전이솔명현고우저수평조，량조전이솔차별현저（ p＝0.011），진일보분석，고수평조발생림파결、폐전이고우저수평조，유명현통계학차이（ p﹤0.05）。결론：혈청Tg음성시，TgAb가작위DTC술후전이/복발적감측지표。TgAb치월고，발생전이/복발가능성월대。
Objective:To study the clinical value of antithyroglobulin antibodies( TgAb)in differentiated thyroid carcinoma( DTC)postoperative metastasis. Methods:To analyze the clinical data of 50 cases with Tg negative and TgAb positive. The cases were divided into two groups:35 cases of postoperative with recurrence or metastasis( group M)and 15 cases without recurrence or metastasis( group N)to observe the TgAb values. According to TgAb levels, cases were divided into low level group(100-2000IU/ml)and high level group( ﹥2000IU/ml)to study the metas-tasis rates and sites of DTC patients in different TgAb level. Results:The TgAb value of postoperative with recurrence or metastasis group was obviously higher than that without recurrence or metastasis(u=120. 500,p=0. 002). The differences between high and low levels group of serum TgAb transfer rate were significant(p=0. 011),The high lev-el group was significantly higher than low level group,further analysis of the light level group,the high level group oc-currence rate of lymph node metastasis and lung metastasis were higher than low level group(p﹤0. 05). Conclu/sion:When serum Tg is negative,TgAb can be used as the monitoring index of recurrence of DTC operation. The high-er the TgAb value,the more possibility of the relapse.
