CAJ | 학술논문

目的：观察斯钙素-1（STC-1）在喉癌患者和健康人群血清中的表达，探讨STC-1与喉癌患者临床病理特征的关系及对预后判断的指导意义。方法：应用Real time PCR和ELISA方法从基因水平和蛋白水平对喉癌患者及健康人群进行STC-1表达分析，并结合患者病理指标、病理分型和临床随访资料进行回顾性分析。结果：基因水平和蛋白水平检测发现STC-1在喉癌患者血清中表达高于健康对照人群血清中的表达。STC-1表达与病理分化等喉癌血清学指标有一定的相关性，且与喉癌的大小、是否转移及临床分型等密切相关。结论：首次发现STC-1在喉癌血清中高表达，且其表达水平与喉癌的病理分期及不良预后密切相关，是喉癌潜在的诊断预警指标物。
목적：관찰사개소-1（STC-1）재후암환자화건강인군혈청중적표체，탐토STC-1여후암환자림상병리특정적관계급대예후판단적지도의의。방법：응용Real time PCR화ELISA방법종기인수평화단백수평대후암환자급건강인군진행STC-1표체분석，병결합환자병리지표、병리분형화림상수방자료진행회고성분석。결과：기인수평화단백수평검측발현STC-1재후암환자혈청중표체고우건강대조인군혈청중적표체。STC-1표체여병리분화등후암혈청학지표유일정적상관성，차여후암적대소、시부전이급림상분형등밀절상관。결론：수차발현STC-1재후암혈청중고표체，차기표체수평여후암적병리분기급불량예후밀절상관，시후암잠재적진단예경지표물。
Objective:To observe the expression of STC-1 in laryngeal cancer patients to explore the clinical and pathological features and its significance on prognostic judgment. Methods:Real time PCR and ELISA methods were used to measure the expression level of STC-1 in laryngeal cancer and the healthy persons. Results:STC-1 was highly expressed in laryngeal cancer than controls,and expression of STC-1 had closed relationship with pathological differentiation,diameters and clinical classification. Conclusion:STC-1 is highly expressed in laryngeal cancer,and its expression level in laryngeal cancer has closed relationship with pathological differentiation and poor prognosis,to be a potential early diagnosis biomarker for laryngeal cancer patients.