肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2015年
4期
260-262
,共3页
米哲涛%臧志方%张秀甫%张生永%范力
米哲濤%臧誌方%張秀甫%張生永%範力
미철도%장지방%장수보%장생영%범력
食管肿瘤%放射疗法%肿瘤退缩%治疗结果
食管腫瘤%放射療法%腫瘤退縮%治療結果
식관종류%방사요법%종류퇴축%치료결과
Esophageal neoplasms%Radiotherapy%Tumor regression%Treatment outcome
目的 分析影响食管癌放疗肿瘤退缩速度的相关性因素,探讨食管癌放疗近期效果与肿瘤退缩速度的关系.方法 选取初治食管鳞状细胞癌患者68例,给予三维适形调强放疗,处方剂量95％计划靶区(PTV) 64 Gy,32次分割,根据放疗中(达32 Gy时)及放疗结束(达64 Gy时)肿瘤退缩分级情况分为快速退缩组、缓慢退缩组、残留组,分析肿瘤退缩与患者年龄、性别、食管癌分型、病变部位、病变长度的关系,以及退缩速度与放疗效果的关系.结果 患者年龄、性别、病变分型、部位对肿瘤退缩无影响(P＞0.05).食管病变长度与肿瘤病变退缩有关,病变长度≤5 cm患者在快速退缩组、缓慢退缩组、残留组比例分别为88.9％(16/18)、69.2％(18/26)、12.5％(3/24)(x2=27.923,P＜ 0.05),病变越长退缩越慢.食管癌放疗近期效果与肿瘤退缩速度呈正相关(r=0.415,P＜0.05).结论 食管癌原发病灶长度是影响放疗肿瘤退缩速度的因素,也是影响食管癌放疗近期效果的因素.
目的 分析影響食管癌放療腫瘤退縮速度的相關性因素,探討食管癌放療近期效果與腫瘤退縮速度的關繫.方法 選取初治食管鱗狀細胞癌患者68例,給予三維適形調彊放療,處方劑量95％計劃靶區(PTV) 64 Gy,32次分割,根據放療中(達32 Gy時)及放療結束(達64 Gy時)腫瘤退縮分級情況分為快速退縮組、緩慢退縮組、殘留組,分析腫瘤退縮與患者年齡、性彆、食管癌分型、病變部位、病變長度的關繫,以及退縮速度與放療效果的關繫.結果 患者年齡、性彆、病變分型、部位對腫瘤退縮無影響(P＞0.05).食管病變長度與腫瘤病變退縮有關,病變長度≤5 cm患者在快速退縮組、緩慢退縮組、殘留組比例分彆為88.9％(16/18)、69.2％(18/26)、12.5％(3/24)(x2=27.923,P＜ 0.05),病變越長退縮越慢.食管癌放療近期效果與腫瘤退縮速度呈正相關(r=0.415,P＜0.05).結論 食管癌原髮病竈長度是影響放療腫瘤退縮速度的因素,也是影響食管癌放療近期效果的因素.
목적 분석영향식관암방료종류퇴축속도적상관성인소,탐토식관암방료근기효과여종류퇴축속도적관계.방법 선취초치식관린상세포암환자68례,급여삼유괄형조강방료,처방제량95％계화파구(PTV) 64 Gy,32차분할,근거방료중(체32 Gy시)급방료결속(체64 Gy시)종류퇴축분급정황분위쾌속퇴축조、완만퇴축조、잔류조,분석종류퇴축여환자년령、성별、식관암분형、병변부위、병변장도적관계,이급퇴축속도여방료효과적관계.결과 환자년령、성별、병변분형、부위대종류퇴축무영향(P＞0.05).식관병변장도여종류병변퇴축유관,병변장도≤5 cm환자재쾌속퇴축조、완만퇴축조、잔류조비례분별위88.9％(16/18)、69.2％(18/26)、12.5％(3/24)(x2=27.923,P＜ 0.05),병변월장퇴축월만.식관암방료근기효과여종류퇴축속도정정상관(r=0.415,P＜0.05).결론 식관암원발병조장도시영향방료종류퇴축속도적인소,야시영향식관암방료근기효과적인소.
Objective To explore the related factors of tumor regression speed during radiotherapy for esophageal cancer and analyze the relationship between recent clinical curative effect and tumor regression speed.Methods 68 previously untreated esophageal cancer patients were treated with three dimensional conformal intensity modulated radiation therapy (3D-IMRT).The radiation dose was 64 Gy/32 times (95 ％ PTV).All the patients were divided into 3 groups according to the size of primary lesions during the entire course of radiotherapy.Fast regression was defined as a complete response before dose 32 Gy,slow regression with dose in the range of 64 Gy and other cases as residual disease.The correlations of tumor regression speed with age,gender,classification,length of lesion and the lesion location were analyzed.And the relationship between recent clinical curative effect and tumor regression speed was discussed.Results The age,gender,classification and the lesion location were not associated with tumor regression (P ＞ 0.05).There was a negative correlation between tumor regression speed and the length of lesion [88.9 ％ (16/18),69.2 ％ (18/26) and 12.5 ％ (3/24) in fast,slow and residual group,respectively,x2 =27.923,P ＜ 0.05].There was a positive correlation between recent clinical curative effect and tumor regression speed (r =0.415,P ＜ 0.05).Conclusion The length of primary lesion is an independent risk factor for recent clinical curative effect and tumor regression speed of esophageal cancer patients treated with 3D-IMRT.
