肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2015年
4期
250-252
,共3页
黄琴%刘虹%李燕%杨晓丰%王晓敏
黃琴%劉虹%李燕%楊曉豐%王曉敏
황금%류홍%리연%양효봉%왕효민
多发性骨髓瘤%PET-CT%分期
多髮性骨髓瘤%PET-CT%分期
다발성골수류%PET-CT%분기
Multiple myeloma%Positron emission tomography-computed tomography%Stage
目的 探讨PET-CT检查在多发性骨髓瘤(MM)分期中的意义,分析PET-CT检查结果与实验室检查指标的相关性.方法 收集新疆维吾尔自治区人民医院血液科2007年3月至2014年2月收治的初诊MM患者78例,平均年龄61.24岁,治疗前检测血红蛋白、清蛋白、βr微球蛋白(β2-M)及乳酸脱氢酶的水平;同时行PET-CT检查,测量脊柱、骨盆、肋骨的最大标准摄取值(SUVmax),每例患者取其平均SUV,并计数每例患者PET-CT检出的病灶数,观察平均SUV及病灶数在不同分期患者中有无差异.观察平均SUV、病灶数与血红蛋白、清蛋白、β2-M及乳酸脱氢酶的关系.结果 所有患者按ISS分期分为3期,Ⅰ期患者(10例)平均SUV值为1.84±0.28,Ⅱ期患者(45例)为3.74±0.42,Ⅲ期患者(23例)为6.02±0.93,各期间SUV值差异有统计学意义(均P＜0.05),平均SUV值与β 2-M(r=0.862,P＜ 0.001)、乳酸脱氢酶(r=0.592,P＜0.001)呈正相关,与清蛋白(r=-0.762,P＜0.001)、血红蛋白(r=-0.685,P＜0.001)呈负相关.患者按病灶数≤3个和＞3个划分,两组低血红蛋白、高乳酸脱氢酶、高βrM患者比例差异有统计学意义(P＜0.05).结论 PET-CT在一定程度上反映肿瘤负荷,对骨髓瘤的分期有指导意义,有助于制定个体化的治疗方案.
目的 探討PET-CT檢查在多髮性骨髓瘤(MM)分期中的意義,分析PET-CT檢查結果與實驗室檢查指標的相關性.方法 收集新疆維吾爾自治區人民醫院血液科2007年3月至2014年2月收治的初診MM患者78例,平均年齡61.24歲,治療前檢測血紅蛋白、清蛋白、βr微毬蛋白(β2-M)及乳痠脫氫酶的水平;同時行PET-CT檢查,測量脊柱、骨盆、肋骨的最大標準攝取值(SUVmax),每例患者取其平均SUV,併計數每例患者PET-CT檢齣的病竈數,觀察平均SUV及病竈數在不同分期患者中有無差異.觀察平均SUV、病竈數與血紅蛋白、清蛋白、β2-M及乳痠脫氫酶的關繫.結果 所有患者按ISS分期分為3期,Ⅰ期患者(10例)平均SUV值為1.84±0.28,Ⅱ期患者(45例)為3.74±0.42,Ⅲ期患者(23例)為6.02±0.93,各期間SUV值差異有統計學意義(均P＜0.05),平均SUV值與β 2-M(r=0.862,P＜ 0.001)、乳痠脫氫酶(r=0.592,P＜0.001)呈正相關,與清蛋白(r=-0.762,P＜0.001)、血紅蛋白(r=-0.685,P＜0.001)呈負相關.患者按病竈數≤3箇和＞3箇劃分,兩組低血紅蛋白、高乳痠脫氫酶、高βrM患者比例差異有統計學意義(P＜0.05).結論 PET-CT在一定程度上反映腫瘤負荷,對骨髓瘤的分期有指導意義,有助于製定箇體化的治療方案.
목적 탐토PET-CT검사재다발성골수류(MM)분기중적의의,분석PET-CT검사결과여실험실검사지표적상관성.방법 수집신강유오이자치구인민의원혈액과2007년3월지2014년2월수치적초진MM환자78례,평균년령61.24세,치료전검측혈홍단백、청단백、βr미구단백(β2-M)급유산탈경매적수평;동시행PET-CT검사,측량척주、골분、륵골적최대표준섭취치(SUVmax),매례환자취기평균SUV,병계수매례환자PET-CT검출적병조수,관찰평균SUV급병조수재불동분기환자중유무차이.관찰평균SUV、병조수여혈홍단백、청단백、β2-M급유산탈경매적관계.결과 소유환자안ISS분기분위3기,Ⅰ기환자(10례)평균SUV치위1.84±0.28,Ⅱ기환자(45례)위3.74±0.42,Ⅲ기환자(23례)위6.02±0.93,각기간SUV치차이유통계학의의(균P＜0.05),평균SUV치여β 2-M(r=0.862,P＜ 0.001)、유산탈경매(r=0.592,P＜0.001)정정상관,여청단백(r=-0.762,P＜0.001)、혈홍단백(r=-0.685,P＜0.001)정부상관.환자안병조수≤3개화＞3개화분,량조저혈홍단백、고유산탈경매、고βrM환자비례차이유통계학의의(P＜0.05).결론 PET-CT재일정정도상반영종류부하,대골수류적분기유지도의의,유조우제정개체화적치료방안.
Objective To investigate the staging significance of PET-CT in multiple myeloma,and to observe the relationship between baseline PET-CT and clinical parameters in multiple myeloma.Methods 78 cases newly diagnosed MM patients were selected from the Department of Hematology,the Xinjiang Uygur Autonomous Region people's Hospital from March 2007 to February 2014,with average age 61.24 years old.The levels of hemoglobin,albumin,beta 2 microglobulin and lactate dehydrogenase were detected before the treatment.PET-CT was performed to measure SUVmax in the spine,pelvis and rib with an average of the SUVmax in each case,and the number of FDG-avid focal lesions in every patient was counted.The difference of the SUVmax or FLS in different stages and the relationship between SUVmax or FLS and clinical parameters in MM were observed.Results All the patients were divided into 3 stages depending on ISS staging.The average SUV values in 10 cases of stage Ⅰ,45 cases of stage Ⅱ and 23 cases of stage Ⅲ were 1.84±0.28,3.74±0.42 and 6.02±0.93,respectively,and SUV values was significantly different among different groups (P ＜ 0.05).SUV values were positively correlated with levels of beta 2 microglobulin (r =0.862,P ＜ 0.001) and lactate dehydrogenase (r =0.592,P ＜ 0.001),and negatively correlated with albumin (r =-0.762,P ＜ 0.001) and hemoglobin levels (r =-0.685,P ＜ 0.001).The number of lesions had a correlation with low hemoglobin,high lactate dehydrogenase and high beta 2 microglobulin (P ＜ 0.05).Conclusion PET-CT can reflect tumor burden to some extent,and has the guiding significance for MM stage,which contributes to developing individualized treatment programs.
