肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2015年
4期
280-282
,共3页
天冬氨酸(天冬酰胺酰)β羟化酶%肿瘤%诊断
天鼕氨痠(天鼕酰胺酰)β羥化酶%腫瘤%診斷
천동안산(천동선알선)β간화매%종류%진단
Aspartyl-(asparaginyl) β-hydroxylase%Neoplasms%Diagnosis
天冬氨酸(天冬酰胺酰)β羟化酶(AAH)是一种Ⅱ型跨膜蛋白,定位于内质网膜上,具有α酮戊二酸依赖的加双氧酶活性,能够对含有EGF样结构的蛋白上的L-天冬氨酸和L-天冬酰胺酰上的β碳原子进行羟化修饰.AAH在多种人类肿瘤组织中表达增加,在除了外滋养层细胞和肾上腺细胞以外的正常组织中几乎不表达.肿瘤组织中高表达的AAH定位于细胞膜上,能够对Notch及其配体以及细胞外黏附分子进行羟基化修饰,增加细胞的运动和侵袭能力.AAH是一种有潜力的肿瘤检测和诊断分子标志物.
天鼕氨痠(天鼕酰胺酰)β羥化酶(AAH)是一種Ⅱ型跨膜蛋白,定位于內質網膜上,具有α酮戊二痠依賴的加雙氧酶活性,能夠對含有EGF樣結構的蛋白上的L-天鼕氨痠和L-天鼕酰胺酰上的β碳原子進行羥化脩飾.AAH在多種人類腫瘤組織中錶達增加,在除瞭外滋養層細胞和腎上腺細胞以外的正常組織中幾乎不錶達.腫瘤組織中高錶達的AAH定位于細胞膜上,能夠對Notch及其配體以及細胞外黏附分子進行羥基化脩飾,增加細胞的運動和侵襲能力.AAH是一種有潛力的腫瘤檢測和診斷分子標誌物.
천동안산(천동선알선)β간화매(AAH)시일충Ⅱ형과막단백,정위우내질망막상,구유α동무이산의뢰적가쌍양매활성,능구대함유EGF양결구적단백상적L-천동안산화L-천동선알선상적β탄원자진행간화수식.AAH재다충인류종류조직중표체증가,재제료외자양층세포화신상선세포이외적정상조직중궤호불표체.종류조직중고표체적AAH정위우세포막상,능구대Notch급기배체이급세포외점부분자진행간기화수식,증가세포적운동화침습능력.AAH시일충유잠력적종류검측화진단분자표지물.
Aspartyl-(asparaginyl) β-hydroxylase (AAH) is a type 2 transmembrane protein and a member of the α-ketoglutarate-dependent dioxygenase family of proteins.AAH catalyzes hydroxylation of specific aspartyl and asparaginyl residues in epidermal growth factor-like domains of proteins.Overexpression of AAH is found in many types of cancer tissues,however,AAH expression is found only in normal placenta and paranephros tissues.AAH can translocate to cell membrane from endoplasmic reticulum membrane when it is overexpressed in cancer cell,which hydroxylate proteins such as Notch,Jagged,and cellular adhesion molecules that regulate cell migration and invasion.AAH is a potential biomarker for cancer diagnosis.
