肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2015年
4期
283-286
,共4页
Oct-4%肿瘤干细胞
Oct-4%腫瘤榦細胞
Oct-4%종류간세포
Oct-4%Cancer stem cell
干细胞(SC)是一类具有潜在自我更新和分化能力的初始细胞,在一定条件下,它可以增殖并分化为多种功能细胞.核蛋白Oct-4、Nanog和Sox2是3个主要转录调节因子,在维持SC多能特性、抑制SC分化的过程中发挥着核心作用.肿瘤干细胞(CSC)假说认为,在肿瘤组织内很可能也存在着具有不断增殖和分化能力的SC,即CSC,正是CSC导致了肿瘤侵袭生长、转移和对治疗的抗性.确定SC的标志物成为当前肿瘤领域研究的重要方向,而将维持SC的核心调控分子Oct-4、Nanog、Sox2引入CSC领域无疑是目前研究的前沿.现对Oct-4在CSC中的研究进展进行综述.
榦細胞(SC)是一類具有潛在自我更新和分化能力的初始細胞,在一定條件下,它可以增殖併分化為多種功能細胞.覈蛋白Oct-4、Nanog和Sox2是3箇主要轉錄調節因子,在維持SC多能特性、抑製SC分化的過程中髮揮著覈心作用.腫瘤榦細胞(CSC)假說認為,在腫瘤組織內很可能也存在著具有不斷增殖和分化能力的SC,即CSC,正是CSC導緻瞭腫瘤侵襲生長、轉移和對治療的抗性.確定SC的標誌物成為噹前腫瘤領域研究的重要方嚮,而將維持SC的覈心調控分子Oct-4、Nanog、Sox2引入CSC領域無疑是目前研究的前沿.現對Oct-4在CSC中的研究進展進行綜述.
간세포(SC)시일류구유잠재자아경신화분화능력적초시세포,재일정조건하,타가이증식병분화위다충공능세포.핵단백Oct-4、Nanog화Sox2시3개주요전록조절인자,재유지SC다능특성、억제SC분화적과정중발휘착핵심작용.종류간세포(CSC)가설인위,재종류조직내흔가능야존재착구유불단증식화분화능력적SC,즉CSC,정시CSC도치료종류침습생장、전이화대치료적항성.학정SC적표지물성위당전종류영역연구적중요방향,이장유지SC적핵심조공분자Oct-4、Nanog、Sox2인입CSC영역무의시목전연구적전연.현대Oct-4재CSC중적연구진전진행종술.
Stem cell (SC) is a class of initial cells with potential self renewal and differentiation ability.Under certain conditions,it can proliferate and differentiate into various functional ceils.Nucleoprotein Oct-4,Nanog and Sox2 are three major transcription factors,which play central roles in maintaining the pluripotent characteristics and inhibiting SC differentiation.Cancer stem cell(CSC) theory supposed that there is also existing SC-CSC possessing potential self renewal and differentiation abilities in tumor tissues.It is the SC properties of CSC that result in tumor's invasive growth,metastasis and resistance to treatment.Therefore,looking for CSC and determining their markers become an important direction for cancer research.And the introduction of Oct-4,Nanog and Sox2 into CSC research field is undoubtedly the most exciting forefront.
