CAJ | 학술논문

海马是中枢神经系统中记忆回路的重要结构，在人与动物学习、记忆整合中起重要作用。视觉是人们认知接受信息的主要渠道，视觉系统是人们接触外界信息最常用的器官。视网膜作为视觉系统的重要组成部分，在人类认知客观世界中起着关键的作用。研究发现许多机体的病理改变会让患者的认知功能下降，但其存在的分子机制尚不明确。随着对认知功能障碍研究的逐步深入，发现海马及视网膜组织中VEGF和PKC的表达变化与认知功能障碍的发病机制有着密切联系，现就此作一综述。
해마시중추신경계통중기억회로적중요결구，재인여동물학습、기억정합중기중요작용。시각시인문인지접수신식적주요거도，시각계통시인문접촉외계신식최상용적기관。시망막작위시각계통적중요조성부분，재인류인지객관세계중기착관건적작용。연구발현허다궤체적병리개변회양환자적인지공능하강，단기존재적분자궤제상불명학。수착대인지공능장애연구적축보심입，발현해마급시망막조직중VEGF화PKC적표체변화여인지공능장애적발병궤제유착밀절련계，현취차작일종술。
Hippocampus is an important structure of neural memory circuit , which plays an important role in learning and memory integration in human and animal .Vision is the most important channel for people to accept information , while the vision system is the most common organ contacting information from outside .The retina as an important part of the visual system , plays a key role in human cognition of the objective world .The study found that many of pathological changes of the body will make the patients cognitive function decline , but molecular mechanism remains unclear .With the research on cognitive dysfunction was penetrated , the link be-tween how VEGF , PKC expression in hippocampus and retinal tissue and cognitive dysfunction was reviewed in this article .