CAJ | 학술논문

目的：利用现代统计学和数据挖掘方法，挖掘郑钦安的用药规律，为深入研究郑钦安的临床用药规律和学术思想提供统计学依据。方法从《医理真传》与《医法圆通》中收集组成明确的方剂。利用Excel建立方药数据库，采用SPSS 17．0和clementine 12．0软件对数据进行描述统计分析、双变量相关性分析、关联规则分析和聚类分析。结果方剂来源医著不少于3次者15种，来源于《伤寒论》的方剂最多，为42首。使用频次不少于10次的中药32味，排在前10味的中药主要是桂枝汤和四君子汤的药物组成。相关系数大于0．2的药对30对。关联规则分析提取出84条规则。聚类分析得出6组药和7对核心药对。结论发现郑钦安在用药上具有如下几个特点：(1)法宗伤寒，推崇仲景；(2)辨分二纲，药有阴阳；(3)善补脾胃，协和营卫；(4)配伍灵活，用药圆通。
목적：이용현대통계학화수거알굴방법，알굴정흠안적용약규률，위심입연구정흠안적림상용약규률화학술사상제공통계학의거。방법종《의리진전》여《의법원통》중수집조성명학적방제。이용Excel건립방약수거고，채용SPSS 17．0화clementine 12．0연건대수거진행묘술통계분석、쌍변량상관성분석、관련규칙분석화취류분석。결과방제래원의저불소우3차자15충，래원우《상한론》적방제최다，위42수。사용빈차불소우10차적중약32미，배재전10미적중약주요시계지탕화사군자탕적약물조성。상관계수대우0．2적약대30대。관련규칙분석제취출84조규칙。취류분석득출6조약화7대핵심약대。결론발현정흠안재용약상구유여하궤개특점：(1)법종상한，추숭중경；(2)변분이강，약유음양；(3)선보비위，협화영위；(4)배오령활，용약원통。
Objective To excavate the medication regularities of ZHENG Qin-an by means of modern statistics and data mining methods, and provide a statistical basis for in-depth study of ZHENG’s clinical medication regularities and academic thoughts. Methods Prescriptions with specific composition were collected from the True Principles of Medical Science ( Yi Li Zhen Zhuan ) and Flexibility of Medical Method ( Yi Fa Yuan Tong) . Excel is used to set up the prescriptions database, SPSS17. 0 and clemen-tine12. 0 softwares were used to do descriptive statistical analysis, bivariate correlation analysis, association rules analysis, and cluster analysis. Results 15 prescriptions come from at least three medical books, prescriptions from Treatise on Cold Damages rank most, totalling up to 42. 32 kinds of Chinese medicinals are used not less than 10 times. The Chinese medicinals that rank top 10 are mainly the composition of Guizhi decoction and Sijunzi decoction. 30 herb pairs’ correlation coefficient is greater than 0. 2. Associa-tion rules analysis has extracted out 84 rules. 6 groups of medicinals and 7 core herb pairs have been ex-tracted by cluster analysis. Conclusion It is found that ZHENG’s drug application has the following char-acteristics:(1) his medication regularities follow Cold Damages, and respect Zhong Jing;(2) pattern di-agnosis and medicines both should be distinguished by yin and yang; ( 3 ) good at invigorating the spleen and stomach, coordinating nutrient qi and defense qi;(4) flexible compatibility and drug application.