CAJ | 학술논문

目的：探究预先短暂性缺血发作时间、发作次数与脑梗死发作间隔对后继脑梗死患者神经的保护作用，为临床治疗提供指导。方法回顾性选取自2010‐02来我院就诊的脑梗死患者213例为研究对象，其中不存在预先T IA患者131例（61.50％）为脑梗死A组，预先发生T IA患者82例（38.50％）为脑梗死B组，采用日常生活活动能力（ADL ）评分标准，从预先短暂性脑缺血发作时间、发作次数与脑梗死发作时间间隔三个方面分析2组患者在神经功能恢复方面的情况。结果脑梗死A组Ⅰ级预后79例（60.31％），脑梗死B组Ⅰ级预后56例（68.29％），2组差异无统计学意义（ P＞0.05），但脑梗死B组预先短暂性脑缺血发作次数在2～3次、发作时间＜10 min与脑梗死间隔≤1周时与脑梗死A组差异有统计学意义（ P＜0.05）。结论脑梗死前预先短暂性脑缺血发作可能会产生神经保护作用，其神经保护作用与短暂性缺血发作持续时间、发作次数及与脑梗死时间间隔具有一定关系。
목적：탐구예선단잠성결혈발작시간、발작차수여뇌경사발작간격대후계뇌경사환자신경적보호작용，위림상치료제공지도。방법회고성선취자2010‐02래아원취진적뇌경사환자213례위연구대상，기중불존재예선T IA환자131례（61.50％）위뇌경사A조，예선발생T IA환자82례（38.50％）위뇌경사B조，채용일상생활활동능력（ADL ）평분표준，종예선단잠성뇌결혈발작시간、발작차수여뇌경사발작시간간격삼개방면분석2조환자재신경공능회복방면적정황。결과뇌경사A조Ⅰ급예후79례（60.31％），뇌경사B조Ⅰ급예후56례（68.29％），2조차이무통계학의의（ P＞0.05），단뇌경사B조예선단잠성뇌결혈발작차수재2～3차、발작시간＜10 min여뇌경사간격≤1주시여뇌경사A조차이유통계학의의（ P＜0.05）。결론뇌경사전예선단잠성뇌결혈발작가능회산생신경보호작용，기신경보호작용여단잠성결혈발작지속시간、발작차수급여뇌경사시간간격구유일정관계。
Objective To explore neuroprotective effect of time and number of previous transient ischemic attack on cere‐bral infarction ,providing guidance for clinical treatment.Methods We retrospectively selected 213 patients with cerebral in‐farction from 2010 February in our hospital as research objects ,among which 131 patients with non‐previous TIA were consid‐ered as group A(61.50% ) ,while 82 cases with previous TIA as group B (38.50% ). The frequency of TIA as well as onset time of cerebral infarction were assessed by activities of daily living (ADL) between two groups to analyze the nerve functional recovery.Results 79 cases (60.31% ) in group A reached grade I in prognosis ,and 56 cases (68.29% ) in B group ,and the difference had no statistical significance (χ2 =1.386 ,P>0.05). Episode in 2‐3 times ,duration less than 10 minutes and inter‐val with one week or less in group B had significant difference compared with group A (P<0.05).Conclusion Previous transi‐ent ischemic attack on cerebral infarction may have neuroprotective effect ,which could be related to frequency ,duration and in‐terval.