CAJ | 학술논문

目的：观察静脉溶栓治疗频发TIA为临床表现的急性脑梗死患者的疗效及预后。方法选择我院2008‐01‐01—2013‐12‐31以频发TIA为临床表现的急性脑梗死静脉溶栓患者56例为治疗组，选择同期未行溶栓治疗的患者30例为对照组，采用NIHSS评分及改良的Rankin评分评价早期疗效及远期预后。结果2组患者溶栓前ABCD2评分（6.12±3.49vs5.78±4.13，P＝0.23）、DWI阳性率（39.28％vs36.67％，P＝0.19）差别无统计学意义。溶栓后早期治疗有效率（51.78％vs30.00％，P＝0.001）、远期预后预后良好率（48.21％vs33.33％，P＝0.003）差别具有统计学意义。在出血转化率方面（8.93％vs6.67％，P＝0.07）差异无统计学意义。结论以频发TIA为临床表现的急性脑梗死患者静脉溶栓治疗安全有效。
목적：관찰정맥용전치료빈발TIA위림상표현적급성뇌경사환자적료효급예후。방법선택아원2008‐01‐01—2013‐12‐31이빈발TIA위림상표현적급성뇌경사정맥용전환자56례위치료조，선택동기미행용전치료적환자30례위대조조，채용NIHSS평분급개량적Rankin평분평개조기료효급원기예후。결과2조환자용전전ABCD2평분（6.12±3.49vs5.78±4.13，P＝0.23）、DWI양성솔（39.28％vs36.67％，P＝0.19）차별무통계학의의。용전후조기치료유효솔（51.78％vs30.00％，P＝0.001）、원기예후예후량호솔（48.21％vs33.33％，P＝0.003）차별구유통계학의의。재출혈전화솔방면（8.93％vs6.67％，P＝0.07）차이무통계학의의。결론이빈발TIA위림상표현적급성뇌경사환자정맥용전치료안전유효。
Objective To observe the effect and prognosis of acute cerebral infarction patients with main manifestation of clustering TIA treated by intravenous thrombolytic therapy. Methods 56 with acute cerebral infarction patients with clustering TIA as clinical manifestation treated by intravenous thrombolytic therapy in our hospital from 2008 to 2013 were collected as treatment group ,and 30 patients without thrombolytic therapy in the corresponding period were selected as control group . NIHSS and modified Rankin Scale were used to evaluate early therapeutic effect and long‐term prognosis .Results There were no significant differences between the two groups in ABCD2 scale(6.12 ± 3.49 vs 5.78 ± 4.13 ,P=0.23) and positive rate of DWI(39.28% vs 36.67% ,P=0.19) before treated by thrombolysis .The differences were statistically significant in the effec‐tive rate of in early stage after thrombolytic therapy (51.78% vs 30.00% ,P=0.001) and the rate of benign prognosis(48.21%vs 33.33% ,P=0.003). The rate of hemorrhagic transformation showed no statistical difference between two groups (8.93%vs 6.67% ,P=0.07). Conclusion It is safe and effective of intravenous thrombolytic therapy for acute cerebral infarction pa‐tients with clustering TIA as clinical manifestation .