CAJ | 학술논문

目的：探讨甲泼尼龙对抗结核药所致重型药物性肝炎患者的疗效及预后。方法将60例抗结核药物所致重型肝炎患者随机分为治疗组(n=32)和对照(n=28)，两组均给予内科综合治疗，在此基础上治疗组加用甲泼尼龙治疗2周。观察两组的临床疗效与不良反应。结果治疗2周后，治疗组总胆红素水平对照组比较差异有统计学意义(<0.05)。两组出现上消化道出血、继发感染等并发症的情况差异无统计学意义(>0.05)。结论短疗程甲泼尼龙的应用可提高抗结核药物所致重型肝炎患者救治的成功率。如严格把握糖皮质激素应用指征及治疗时机，其临床应用是较为安全的。
목적：탐토갑발니룡대항결핵약소치중형약물성간염환자적료효급예후。방법장60례항결핵약물소치중형간염환자수궤분위치료조(n=32)화대조(n=28)，량조균급여내과종합치료，재차기출상치료조가용갑발니룡치료2주。관찰량조적림상료효여불량반응。결과치료2주후，치료조총담홍소수평대조조비교차이유통계학의의(<0.05)。량조출현상소화도출혈、계발감염등병발증적정황차이무통계학의의(>0.05)。결론단료정갑발니룡적응용가제고항결핵약물소치중형간염환자구치적성공솔。여엄격파악당피질격소응용지정급치료시궤，기림상응용시교위안전적。
Objective To observe the clinical efficacy of shortr-term methylprednisolone to drug-induced liver failure which induced only by antituberculosis drugs. Methods Sixty patients with drug-induced liver failure which induced antituberculosis drugs were randomly divided into experiment group(n=32) and control group(n=28).Control group was received with practice of integrated treatment,and treatment group was received practice of integrated treatment and methylprednisolone for 2 weeks.After treatment,the success rate and adverse reaction were compared between the two groups.Results After two weeks therapy,the TBIL value descended significantly in the experiment group,compared to those in the control group,it had statistical diffbrence ( <0.05),but there were no significant statistical differences between the two groups in the incidence of complications ( >0.05). Conclusion The patiems with heavy tendency hepatitis which induced only by antituberculosis drugs were given short-term methylpredrtisolone treatment in the early stage maybe can improve the success rate, clinical application of methylpre-drtisolone is relatively safe.