CAJ | 학술논문

目的：探讨应用三维超声心动图(RT-3DE)评价蒽环类药物对于不同心脏基础情况乳腺癌患者的左室收缩同步性影响。方法选取40例乳腺癌症患者,分为心脏正常组和心脏高危组,每例分为化疗前、化疗6周期后2个阶段；并选取20例未化疗乳腺癌患者为对照组。每组在各阶段行RT-3DE 检查,应用 QLAB 软件获得左室17节段容积-时间曲线,并定量分析左室收缩同步性指标。结果化疗前,3组检查者的左室17节段容积-时间曲线形态较为一致,起伏有序；心脏正常组及心脏高危组的 RT-3DE 各测量参数分别与对照组比较差异无统计学意义(P >0．05)。化疗6周期后,心脏正常组及高危组的曲线形态改变明显,走形高低不一,同时这两组患者中部分测量参数较化疗前有所增高,这两种改变均以高危组改变更为明显(P <0．01)。结论蒽环类药物对于左室心肌的收缩同步性有影响,特别是对于已经有心脏基础疾病的患者。
목적：탐토응용삼유초성심동도(RT-3DE)평개은배류약물대우불동심장기출정황유선암환자적좌실수축동보성영향。방법선취40례유선암증환자,분위심장정상조화심장고위조,매례분위화료전、화료6주기후2개계단；병선취20례미화료유선암환자위대조조。매조재각계단행RT-3DE 검사,응용 QLAB 연건획득좌실17절단용적-시간곡선,병정량분석좌실수축동보성지표。결과화료전,3조검사자적좌실17절단용적-시간곡선형태교위일치,기복유서；심장정상조급심장고위조적 RT-3DE 각측량삼수분별여대조조비교차이무통계학의의(P >0．05)。화료6주기후,심장정상조급고위조적곡선형태개변명현,주형고저불일,동시저량조환자중부분측량삼수교화료전유소증고,저량충개변균이고위조개변경위명현(P <0．01)。결론은배류약물대우좌실심기적수축동보성유영향,특별시대우이경유심장기출질병적환자。
Objective To evaluate the left ventricular systolic speckle synchrony by RT-3DE in breast cancer pa-tients with different cardiac status receiving anthracycline. Methods 40 breast cancer patients were divided into normal group and cardiopathy group in 2 stages (before chemotherapy, after the sixth cycle of chemotherapy). 20 patients after surging without chemotherapy were as the control group. They all underwent RT-3DE examination. The QLAB software was used to analyze the data of left ventricular systolic synchrony and to obtain 17-segmental volume-time curves. Results Before chemotherapy, the three groups’ curves were regular parabola and arrange in order, and the data of left ventricular systolic synchrony were not different among the three groups(P > 0. 05). Af-ter the sixth cycle of chemotherapy, in the normal group and cardiopathy group the curves were interlace with each other, and parts of the data of left ventricular systolic synchrony were higher than those in the control group. They all increased significantly in the cardiopathy group (P < 0. 01). Conclusion The left ventricular systolic synchro-ny gets worse in breast cancer patients receiving anthracycline, which can be aggravated in cardiopathy group.