CAJ | 학술논문

目的：探讨2型糖尿病（T2DM）患者代谢综合征（MS）组分与血清谷氨酰转肽酶（γ-GGT）的相关性。方法：445例T2DM患者按MS组分数目分为A、B、C、D组，分别包含1、2、3、4个MS组分，按血清γ-GGT水平分为正常组与异常组，比较不同组间γ-GGT、血糖、血压、血脂、胰岛素及胰岛素抵抗指数(HOMA-IR)等指标。结果：（1）随MS组分的增加，BMI、TG、SUA、γ-GGT水平逐渐升高，差异有统计学意义（P＜0.05）；C、D组SBP、DBP、TC、LDL-C、HDL-C、HOMA-IR明显高于A、B组，B组DBP、HOMA-IR高于A组，C、D组HDL-C明显低于A、B组，D组HDL-C低于C组，差异有统计学意义（P＜0.05）。（2）γ-GGT异常组年龄轻、病程短，且BMI、DBP、TG、FIns、HOMA-IR、SUA、γ-GGT、ALT、AST高于正常组（P＜0.05）。（3）Pearson相关分析显示，γ-GGT与BMI、DBP、SUA、TG、FIns、HOMA-IR呈正相关（r=0.296、0.134、0.411、0.106、0.089、0.082，P＜0.05），与年龄、病程呈负相关（r=-0.088、-0.188，P＜0.05）。多元逐步线性回归分析显示，γ-GGT与BMI、SUA、TG、HOMA-IR呈正相关（B=0.016、0.002、0.081、0.078，P＜0.05），与病程呈负相关（B=-0.011，P＜0.05）。（4）Logistic回归分析示，BMI、TG、FIns、SUA是血清γ-GGT升高的独立危险因素。结论：T2DM患者MS组分与血清γ-GGT水平密切相关，BMI、TG、FIns、SUA是血清γ-GGT升高的独立危险因素。
목적：탐토2형당뇨병（T2DM）환자대사종합정（MS）조분여혈청곡안선전태매（γ-GGT）적상관성。방법：445례T2DM환자안MS조분수목분위A、B、C、D조，분별포함1、2、3、4개MS조분，안혈청γ-GGT수평분위정상조여이상조，비교불동조간γ-GGT、혈당、혈압、혈지、이도소급이도소저항지수(HOMA-IR)등지표。결과：（1）수MS조분적증가，BMI、TG、SUA、γ-GGT수평축점승고，차이유통계학의의（P＜0.05）；C、D조SBP、DBP、TC、LDL-C、HDL-C、HOMA-IR명현고우A、B조，B조DBP、HOMA-IR고우A조，C、D조HDL-C명현저우A、B조，D조HDL-C저우C조，차이유통계학의의（P＜0.05）。（2）γ-GGT이상조년령경、병정단，차BMI、DBP、TG、FIns、HOMA-IR、SUA、γ-GGT、ALT、AST고우정상조（P＜0.05）。（3）Pearson상관분석현시，γ-GGT여BMI、DBP、SUA、TG、FIns、HOMA-IR정정상관（r=0.296、0.134、0.411、0.106、0.089、0.082，P＜0.05），여년령、병정정부상관（r=-0.088、-0.188，P＜0.05）。다원축보선성회귀분석현시，γ-GGT여BMI、SUA、TG、HOMA-IR정정상관（B=0.016、0.002、0.081、0.078，P＜0.05），여병정정부상관（B=-0.011，P＜0.05）。（4）Logistic회귀분석시，BMI、TG、FIns、SUA시혈청γ-GGT승고적독립위험인소。결론：T2DM환자MS조분여혈청γ-GGT수평밀절상관，BMI、TG、FIns、SUA시혈청γ-GGT승고적독립위험인소。
Objective: To investigate the association of metabolism syndrome (MS)and its components with serum γ-glutamyl transpeptidase (γ-GGT) in patients with type 2 diabetes. Methods:Four hundred and forty five type 2 diabetic patients according to the MS group number were divided into A, B, C and D group, respectively with 1, 2, 3, 4 MS components. And then patients were divided into normal and abnormal groups according to the levels of serumγ-GGT.γ-GGT, blood glucose, blood pressure, blood lipid, insulin and insulin resistance index (HOMA-IR) and other indicators of different groups were compared. Results: (1) As the increase of MS component, the level of BMI,TG,SUA,γ-GGT increased gradually (P<0.05);Compared with group A,B, the levels of SBP,DBP,TC,LDL-C,HDL-C, HOMA-IR increased significantly in group C, D. The level of DBP, HOMA-IR in group B were higher than group A. Compared with group A, B, the level of HDL-C decreased significantly in group C, D and the level of HDL-C in group D was lower than group C (P<0.05). (2) Abnormalγ-GGT group presented with young age and short duration, and compared with normal group, the levels of BMI, DBP, TG, FIns, HOMA-IR, SUA,γ-GGT, ALT,AST in the group increased significantly (P<0.05).(3) Pearson correlation analysis revealedγ-GGT was positive correlation with BMI, DBP, SUA, TG, FIns, HOMA-IR (r=0.296,0.134,0.411,0.106,0.089,0.082,P<0.05),and a negative correlation with age and duration(r=-0.088,-0.188,P<0.05). Multiple linear regression showedγ-GGT was positively correlated with BMI, SUA,TG, HOMA-IR (B=0.016,0.002,0.081,0.078,P<0.05),and a negative correlation with duration (B=-0.011,P<0.05). (4)Logistic regression showed BMI, TG, FIns, SUA were independent risk factors for elevated surem γ-GGT. Conclusion: In patients with type 2 diabetes, MS and its components are closely corelated with surem γ-GGT and BMI,TG,Fins and SUA are independent risk factors for elevated suremγ-GGT.