天津医科大学学报
天津醫科大學學報
천진의과대학학보
JOURNAL OF TIANJIN MEDICAL UNIVERSITY
2015年
3期
233-235,251
,共4页
李慧%姜行康%齐士勇%杨宇明%王超%陈晓博%张晓会%徐勇
李慧%薑行康%齊士勇%楊宇明%王超%陳曉博%張曉會%徐勇
리혜%강행강%제사용%양우명%왕초%진효박%장효회%서용
前列腺癌%前列腺穿刺活检%神经周围侵犯%根治性前列腺切除术%预后
前列腺癌%前列腺穿刺活檢%神經週圍侵犯%根治性前列腺切除術%預後
전렬선암%전렬선천자활검%신경주위침범%근치성전렬선절제술%예후
prostate cancer%prostate biopsy%perineural invasion%radical prostatectomy%prognosis
目的:探讨前列腺穿刺活检标本中神经周围侵犯(PNI)对根治性前列腺切除术患者预后的影响。方法:回顾性分析经耻骨后根治性前列腺切除术或腹腔镜根治性前列腺切除术的160例局限性前列腺癌患者的临床资料,所有患者术前均进行前列腺穿刺活检并进行常规石蜡切片后行苏木精-伊红染色,以肿瘤细胞浸润神经束或神经束膜判定为PNI阳性。分析标本中PNI与前列腺癌临床病理特征以及根治性前列腺切除术预后的关系。结果:160例前列腺癌患者中PNI阳性27例(16.9%)。 PNI与前列腺穿刺活检Gleason评分、前列腺癌临床分期、手术切缘阳性有关(P<0.05)。 PNI阳性组患者在根治性前列腺切除术后无生化复发生存期为(75.79±6.38)个月,明显短于PNI阴性组的(88.46±2.41)个月(P<0.05)。 PNI阳性组患者的总生存期为(84.32±2.96)月,而非PNI组总生存期为(94.50±2.38)个月(P<0.05)。结论:前列腺穿刺标本中PNI可作为判断前列腺癌患者根治性前列腺切除术后不良预后的指标。
目的:探討前列腺穿刺活檢標本中神經週圍侵犯(PNI)對根治性前列腺切除術患者預後的影響。方法:迴顧性分析經恥骨後根治性前列腺切除術或腹腔鏡根治性前列腺切除術的160例跼限性前列腺癌患者的臨床資料,所有患者術前均進行前列腺穿刺活檢併進行常規石蠟切片後行囌木精-伊紅染色,以腫瘤細胞浸潤神經束或神經束膜判定為PNI暘性。分析標本中PNI與前列腺癌臨床病理特徵以及根治性前列腺切除術預後的關繫。結果:160例前列腺癌患者中PNI暘性27例(16.9%)。 PNI與前列腺穿刺活檢Gleason評分、前列腺癌臨床分期、手術切緣暘性有關(P<0.05)。 PNI暘性組患者在根治性前列腺切除術後無生化複髮生存期為(75.79±6.38)箇月,明顯短于PNI陰性組的(88.46±2.41)箇月(P<0.05)。 PNI暘性組患者的總生存期為(84.32±2.96)月,而非PNI組總生存期為(94.50±2.38)箇月(P<0.05)。結論:前列腺穿刺標本中PNI可作為判斷前列腺癌患者根治性前列腺切除術後不良預後的指標。
목적:탐토전렬선천자활검표본중신경주위침범(PNI)대근치성전렬선절제술환자예후적영향。방법:회고성분석경치골후근치성전렬선절제술혹복강경근치성전렬선절제술적160례국한성전렬선암환자적림상자료,소유환자술전균진행전렬선천자활검병진행상규석사절편후행소목정-이홍염색,이종류세포침윤신경속혹신경속막판정위PNI양성。분석표본중PNI여전렬선암림상병리특정이급근치성전렬선절제술예후적관계。결과:160례전렬선암환자중PNI양성27례(16.9%)。 PNI여전렬선천자활검Gleason평분、전렬선암림상분기、수술절연양성유관(P<0.05)。 PNI양성조환자재근치성전렬선절제술후무생화복발생존기위(75.79±6.38)개월,명현단우PNI음성조적(88.46±2.41)개월(P<0.05)。 PNI양성조환자적총생존기위(84.32±2.96)월,이비PNI조총생존기위(94.50±2.38)개월(P<0.05)。결론:전렬선천자표본중PNI가작위판단전렬선암환자근치성전렬선절제술후불량예후적지표。
O bjective:To investigate the relationship between perineural invasion (PNI) in prostate biopsy and radical prostatectomy outcomes. Methods:One hundred and sixty patients undergoing radical prostatectomy were analyzed retrospectively. Paraffin sections of the specimens from all patients who underwent prostate biopsy were stained with HE. PNI-positive was defined as infiltration of carcinoma cell into the perineurium or neural fascia. The association of PNI with clinicopathologic features of prostate cancer and radical prostatectomy outcomes were analyzed. Results:PNI was positive in 16.9%(27/160) of the patients. The prostate biopsy Gleason score,clinical staging of prostate cancer,surgical margin were significantly associated with PNI (P<0.05). The biochemical-recurrence-free survival time of PNI-positive patients after radical prostatectomy was shorter than that of the PNI-negative patients [(75.79+6.38) months vs (88.46+2.41) months, P<0.05]. Furthermore, the overall survival time of PNI-positive patients was shorter than that of the PNI-negative [(84.32+2.96) months vs (94.50+2.38) months, P<0.05]. Conclusion:PNI in prostate biopsy can be used as one of the indicators to predict adverse prostatectomy outcomes.