中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
9期
12-14
,共3页
利福平%脑卒中%肺结核%药物性肝损伤%联合化疗
利福平%腦卒中%肺結覈%藥物性肝損傷%聯閤化療
리복평%뇌졸중%폐결핵%약물성간손상%연합화료
Rifampin%Cerebral apoplexy%Tuberculosis%Drug-induced liver injury%Combination chemotherapy
目的：探讨含利福平联合化疗方案治疗脑卒中合并肺结核患者的临床疗效及安全性。方法选取2010‐08—2014‐07我院收治的脑卒中合并肺结核患者196例，按随机数字表分成观察组与对照组各98例。对比2组治疗方案的临床疗效，监测2组患者肝功能变化情况、药物性肝损伤发生率、药物性肝损伤程度、出现肝损伤的时间及其主要的临床症状等。结果抗结核治疗后观察组患者的总体有效率77.55％（76／98）明显高于对照组55.10％（54／98）；观察组的肝损伤发生率13.27％明显小于对照组32.65％，差异具有统计学意义（P＜0.05）。ALT ＞120～200 U／L、ALT＞200 U／L 和TBIL＞34.2μmol／L观察组患者的肝损伤程度明显比对照组低，差异均具有统计学意义（P＜0.05）；但ALT 80～U／L2组患者区别不大，差异无统计学意义（P＞0.05）。2组患者出现药物性损伤的时间大多集中在8周内，差异无统计学意义（P＞0.05）。结论含利福平联合化疗方案对脑卒中合并肺结核患者的疗效好，肝功能损害小，安全性较高，值得临床应用推广。
目的：探討含利福平聯閤化療方案治療腦卒中閤併肺結覈患者的臨床療效及安全性。方法選取2010‐08—2014‐07我院收治的腦卒中閤併肺結覈患者196例，按隨機數字錶分成觀察組與對照組各98例。對比2組治療方案的臨床療效，鑑測2組患者肝功能變化情況、藥物性肝損傷髮生率、藥物性肝損傷程度、齣現肝損傷的時間及其主要的臨床癥狀等。結果抗結覈治療後觀察組患者的總體有效率77.55％（76／98）明顯高于對照組55.10％（54／98）；觀察組的肝損傷髮生率13.27％明顯小于對照組32.65％，差異具有統計學意義（P＜0.05）。ALT ＞120～200 U／L、ALT＞200 U／L 和TBIL＞34.2μmol／L觀察組患者的肝損傷程度明顯比對照組低，差異均具有統計學意義（P＜0.05）；但ALT 80～U／L2組患者區彆不大，差異無統計學意義（P＞0.05）。2組患者齣現藥物性損傷的時間大多集中在8週內，差異無統計學意義（P＞0.05）。結論含利福平聯閤化療方案對腦卒中閤併肺結覈患者的療效好，肝功能損害小，安全性較高，值得臨床應用推廣。
목적：탐토함리복평연합화료방안치료뇌졸중합병폐결핵환자적림상료효급안전성。방법선취2010‐08—2014‐07아원수치적뇌졸중합병폐결핵환자196례，안수궤수자표분성관찰조여대조조각98례。대비2조치료방안적림상료효，감측2조환자간공능변화정황、약물성간손상발생솔、약물성간손상정도、출현간손상적시간급기주요적림상증상등。결과항결핵치료후관찰조환자적총체유효솔77.55％（76／98）명현고우대조조55.10％（54／98）；관찰조적간손상발생솔13.27％명현소우대조조32.65％，차이구유통계학의의（P＜0.05）。ALT ＞120～200 U／L、ALT＞200 U／L 화TBIL＞34.2μmol／L관찰조환자적간손상정도명현비대조조저，차이균구유통계학의의（P＜0.05）；단ALT 80～U／L2조환자구별불대，차이무통계학의의（P＞0.05）。2조환자출현약물성손상적시간대다집중재8주내，차이무통계학의의（P＞0.05）。결론함리복평연합화료방안대뇌졸중합병폐결핵환자적료효호，간공능손해소，안전성교고，치득림상응용추엄。
Objective To explore the efficacy and safety of chemotherapy regimens including rifampin in treatment of stroke complicated with tuberculosis. Methods 196 cases with pulmonary tuberculosis and stroke from August 2010 to July 2014 in our hospital were chosen and divided into observation group and control group according to random number table ,98 cases in each group. The efficacy ,change of liver function ,incidence and onset of drug‐induced liver disease ,and the main symptom were monitored and compared in two groups before and after treatment. Results After anti‐tuberculosis treatment , total effective rate of 77.55% (76/98) in the observation group was significantly higher than 55.10% (54/98) in the control group. The incidence of liver damage in observation group was 13.27% ,which was obviously less than 32.65% in the control group ,with a statistical difference (P<0.05). The value of ALT more than 120 U/L ,ALT more than 200 U/L and TBIL more than 34.2 μmol/L in observation group was obviously lower than that in the control group ,and the differences were sta‐tistically significant (P<0.05);but the ALT less than 80 U/L in two groups showed no significant difference (P>0.05). The onset of drug‐induced injury in two groups all occurred at 8 weeks ,with no significant difference (P> 0.05). Conclusion Chemotherapy regimens including rifampin has a curative effect on stroke complicated with tuberculosis ,with small liver func‐tion damage and high security ,which should be worthy of clinical application.
