CAJ | 학술논문

目的：探讨血清胱抑素C（Cys C）水平在急性冠脉综合征（ACS）中的预测价值。方法：选取132例行冠状动脉造影检查及治疗的ACS患者[不稳定型心绞痛（UA）组42例，非ST段抬高型心肌梗死（NSTEMI）组46例，ST段抬高型心肌梗死（STEMI）组44例]，同期选取41名冠状动脉造影检查阴性者作为对照组。收集并分析一般临床资料并检测Cys C，计算Gensini积分。结果：（1）各组间Cys C水平比较，差异有统计学意义（F=52.732，P＜0.001）。（2）UA及NSTEMI患者Cys C水平与冠脉Gensini积分呈正相关。（3）多因素Logistic回归分析显示，高龄、吸烟史、Cys C水平升高，高密度脂蛋白水平降低是ACS的影响因素。结论：Cys C水平升高是ACS的危险因素,检测Cys C对冠脉病变狭窄程度的判断有指导意义。
목적：탐토혈청광억소C（Cys C）수평재급성관맥종합정（ACS）중적예측개치。방법：선취132례행관상동맥조영검사급치료적ACS환자[불은정형심교통（UA）조42례，비ST단태고형심기경사（NSTEMI）조46례，ST단태고형심기경사（STEMI）조44례]，동기선취41명관상동맥조영검사음성자작위대조조。수집병분석일반림상자료병검측Cys C，계산Gensini적분。결과：（1）각조간Cys C수평비교，차이유통계학의의（F=52.732，P＜0.001）。（2）UA급NSTEMI환자Cys C수평여관맥Gensini적분정정상관。（3）다인소Logistic회귀분석현시，고령、흡연사、Cys C수평승고，고밀도지단백수평강저시ACS적영향인소。결론：Cys C수평승고시ACS적위험인소,검측Cys C대관맥병변협착정도적판단유지도의의。
Objective:To investigate the predictive capability of cystatin C (Cys C) among patients with acute coronary syndrome(ACS). Methods:A total of 132 subjects with ACS examined by coronary angiography (CAG) were consecutively enrolled and further divided into unstable angina (UA, n=42), non-ST segment elevated myocardial infarction (NSTEMI, n=46) and ST segment elevated myocardial infarction (STEMI, n=44). Forty-one subjects whose CAG results were negative were enrolled in case-control group. The clinical data were collected during hospitalization and Cys C was measured as well. All Gensini scores were evaluated. Results:(1) Statistical differences were found in Cys C levels in each group(F=52.732,P<0.001). (2) Positive correlation was detected between Cys C and Gensini score in UA and NSTEMI patients. (3)Logistic regression analysis showed that the factors affecting ACS were enhanced Cys C, smoking, advanced age and decreased high-density lipoprotein cholesterol. Conclusion:The level of serum Cys C is correlated with the degree of severity in ACS, and it is a risk factor for ACS.