CAJ | 학술논문

胆汁酸作为机体的重要代谢信号分子，参与了糖类、脂肪及能量的代谢。减重手术目前是治疗治疗肥胖症和代谢综合征有效途径之一，但其机制尚不明确。研究发现，减重手术后胆汁酸水平明显升高，并且与代谢综合征改善正相关。由于减重手术后胃肠道生理结构发生变化，必然会对胆汁酸代谢产生影响。本文对胆汁酸对代谢和对减重手术的影响作一综述。
담즙산작위궤체적중요대사신호분자，삼여료당류、지방급능량적대사。감중수술목전시치료치료비반증화대사종합정유효도경지일，단기궤제상불명학。연구발현，감중수술후담즙산수평명현승고，병차여대사종합정개선정상관。유우감중수술후위장도생리결구발생변화，필연회대담즙산대사산생영향。본문대담즙산대대사화대감중수술적영향작일종술。
As an essential metabolic molecule, bile acids regulate triglyceride, cholesterol, energy metabolism. Bariatric surgery offers a treatment that can reduce weight and induce metabolic syndrome, but the mechanism is still unclear. New researches reveal that serum bile acids are elevated after surgery, as well as the improvement of metabolic disease. The surgery changes gastrointestinal tract, resulting in a short circuiting of the enterohepatic circulation of bile acids. Here we review the bile acids metabolism and their effect after bariatric surgery.