中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2015年
5期
456-458
,共3页
糖尿病%神经病理性疼痛%血脂%危险因素
糖尿病%神經病理性疼痛%血脂%危險因素
당뇨병%신경병이성동통%혈지%위험인소
Diabetes mellitus%Neuropathic pain%Blood lipid%Risk factor
目的:分析 T2DM 大鼠神经病理性疼痛的相关危险因素。方法选取雌性清洁级Wistar大鼠分为非糖尿病标准饮食组(NdStd)、糖尿病高脂饮食疼痛组(DbHFP)、糖尿病高脂饮食非疼痛组(DbHFNP),各10只。定期检测每组体重、血糖、TG、TC、HDL‐C、LDL‐C、50%疼痛阈值,评估血脂与疼痛的关系。结果非条件Logistic回归分析显示,TG、LDL‐C、血糖为导致糖尿病神经病变疼痛的危险因素(P<0.05),HDL‐C为糖尿病神经病变疼痛的保护因素(P<0.05),而与 TC和体重无相关性(P>0.05)。结论 TG、LDL‐C及血糖为导致糖尿病神经病毒疼痛的危险因素,HDL‐C为导致糖尿病神经病毒疼痛的保护因素。
目的:分析 T2DM 大鼠神經病理性疼痛的相關危險因素。方法選取雌性清潔級Wistar大鼠分為非糖尿病標準飲食組(NdStd)、糖尿病高脂飲食疼痛組(DbHFP)、糖尿病高脂飲食非疼痛組(DbHFNP),各10隻。定期檢測每組體重、血糖、TG、TC、HDL‐C、LDL‐C、50%疼痛閾值,評估血脂與疼痛的關繫。結果非條件Logistic迴歸分析顯示,TG、LDL‐C、血糖為導緻糖尿病神經病變疼痛的危險因素(P<0.05),HDL‐C為糖尿病神經病變疼痛的保護因素(P<0.05),而與 TC和體重無相關性(P>0.05)。結論 TG、LDL‐C及血糖為導緻糖尿病神經病毒疼痛的危險因素,HDL‐C為導緻糖尿病神經病毒疼痛的保護因素。
목적:분석 T2DM 대서신경병이성동통적상관위험인소。방법선취자성청길급Wistar대서분위비당뇨병표준음식조(NdStd)、당뇨병고지음식동통조(DbHFP)、당뇨병고지음식비동통조(DbHFNP),각10지。정기검측매조체중、혈당、TG、TC、HDL‐C、LDL‐C、50%동통역치,평고혈지여동통적관계。결과비조건Logistic회귀분석현시,TG、LDL‐C、혈당위도치당뇨병신경병변동통적위험인소(P<0.05),HDL‐C위당뇨병신경병변동통적보호인소(P<0.05),이여 TC화체중무상관성(P>0.05)。결론 TG、LDL‐C급혈당위도치당뇨병신경병독동통적위험인소,HDL‐C위도치당뇨병신경병독동통적보호인소。
Objective To explore the related risk factors for neuropathic pain in diabetic rats.Methods Female Wistar rats of clean grade were divided into three groups :Non diabetic standard diet (NdStd) group (n=10) ,diabetic high fat diet and pain (DbHFP) group (n=10) ,and diabetic high fat diet and no pain (DbHFNP) group (n=10).Body weight ,blood glucose ,TG ,TC ,HDL‐C ,LDL‐C and 50%pain threshold were measured regularly to assess the relationship between blood lipids and pain. Results Non‐conditional logistic regression analysis showed that pain threshold was negatively correlated with TG , LDL‐C and blood glucose(P<0.05) ,and positively correlated with HDL‐C (P<0.05). And there was no association between TC and body weight (P> 0.05). Conclusion Pain threshold of diabetic rats was negatively correlated with TG ,LDL‐C and blood glucose ,and positively correlated with HDL‐C.