中华全科医师杂志
中華全科醫師雜誌
중화전과의사잡지
CHINESE JOURNAL OF GENERAL PRACTITIONERS
2015年
5期
345-350
,共6页
血脂异常%危险因素%葡萄糖代谢障碍
血脂異常%危險因素%葡萄糖代謝障礙
혈지이상%위험인소%포도당대사장애
Dyslipidemias%Risk factors%Glucose metabolism disorders
目的 了解杭州市江干区城市化区域居民血脂状况及相关代谢影响因素,为该区域的血脂异常防治提供依据.方法 采用随机整群抽样方法选取3个城市化社区≥18岁常住户籍居民共2 590例,调查分析不同性别、不同年龄组间的血脂代谢异常率;TC、TG、LDL-C、HDL-C水平分别与BMI、腰围、收缩压、舒张压、空腹血糖、糖化血红蛋白、尿酸水平进行Spearmam相关分析,并采用x2检验、x2趋势检验和非条件logistic回归分析方法分析血脂异常与超重或肥胖、高血压、高血糖、高尿酸血症的相关性.结果 总血脂代谢异常率60.0％(1 554/2 590),标化率为57.2％.高TC血症率为42.9％(1 111/2 590),标化率为40.5％,其中边缘升高率为31.7％ (822/2 590),标化率为30.5％;升高率为11.2％(289/2 590),标化率为10.0％.高TG血症率为33.0％(855/2 590),标化率为30.7％,其中边缘升高率为15.3％ (397/2 590),标化率为14.3％;升高率为17.7％ (458/2 590),标化率为16.4％.高LDL-C血症率为30.4％(787/2 590),标化率为28.4％,其中边缘升高率22.9％(594/2 590),标化率为21.7％;升高率为7.5％(193/2 590),标化率6.7％.低HDL-C血症率为12.6％(327/2 590),标化率为12.8％.总血脂代谢异常率及各类型血脂代谢异常率在性别间比较差异均无统计学意义(均P＞0.05).高TC血症、高TG血症、高LDL-C血症、总血脂代谢异常率均随年龄的增加而升高(趋势检验均P ＜0.01),而低HDL-C血症率未随年龄而有趋势变化(趋势检验P＞0.05).Spearmam相关分析结果显示,TC、TG、LDL-C水平均与BMI、腰围、收缩压、舒张压、空腹血糖、糖化血红蛋白、尿酸水平呈正相关(均P＜0.01),而HDL-C水平均与BMI、腰围、收缩压、舒张压、空腹血糖、糖化血红蛋白、尿酸呈负相关(均P＜0.05).总血脂代谢异常率及各类型血脂代谢异常率均随BMI水平的升高呈上升趋势(趋势检验均P＜0.01),各类型血脂代谢异常率在腰围、血压、血糖、血尿酸不同组(升高组和非升高组)间比较差异也均有统计学意义(均P＜ 0.05).非条件logistic回归分析显示,在校正年龄和性别因素后,超重或肥胖、高血压均是高TC血症和高LDL-C血症的危险因素,超重或肥胖、高尿酸血症是低HDL-C血症的危险因素,超重或肥胖、高血压、高血糖和高尿酸血症均为高TG血症和总血脂异常的危险因素.结论 城市化社区人群有较高的血脂代谢异常率,超重或肥胖、高血压、高血糖和高尿酸血症影响血脂代谢,需加强人群血脂异常的监测和综合防治.
目的 瞭解杭州市江榦區城市化區域居民血脂狀況及相關代謝影響因素,為該區域的血脂異常防治提供依據.方法 採用隨機整群抽樣方法選取3箇城市化社區≥18歲常住戶籍居民共2 590例,調查分析不同性彆、不同年齡組間的血脂代謝異常率;TC、TG、LDL-C、HDL-C水平分彆與BMI、腰圍、收縮壓、舒張壓、空腹血糖、糖化血紅蛋白、尿痠水平進行Spearmam相關分析,併採用x2檢驗、x2趨勢檢驗和非條件logistic迴歸分析方法分析血脂異常與超重或肥胖、高血壓、高血糖、高尿痠血癥的相關性.結果 總血脂代謝異常率60.0％(1 554/2 590),標化率為57.2％.高TC血癥率為42.9％(1 111/2 590),標化率為40.5％,其中邊緣升高率為31.7％ (822/2 590),標化率為30.5％;升高率為11.2％(289/2 590),標化率為10.0％.高TG血癥率為33.0％(855/2 590),標化率為30.7％,其中邊緣升高率為15.3％ (397/2 590),標化率為14.3％;升高率為17.7％ (458/2 590),標化率為16.4％.高LDL-C血癥率為30.4％(787/2 590),標化率為28.4％,其中邊緣升高率22.9％(594/2 590),標化率為21.7％;升高率為7.5％(193/2 590),標化率6.7％.低HDL-C血癥率為12.6％(327/2 590),標化率為12.8％.總血脂代謝異常率及各類型血脂代謝異常率在性彆間比較差異均無統計學意義(均P＞0.05).高TC血癥、高TG血癥、高LDL-C血癥、總血脂代謝異常率均隨年齡的增加而升高(趨勢檢驗均P ＜0.01),而低HDL-C血癥率未隨年齡而有趨勢變化(趨勢檢驗P＞0.05).Spearmam相關分析結果顯示,TC、TG、LDL-C水平均與BMI、腰圍、收縮壓、舒張壓、空腹血糖、糖化血紅蛋白、尿痠水平呈正相關(均P＜0.01),而HDL-C水平均與BMI、腰圍、收縮壓、舒張壓、空腹血糖、糖化血紅蛋白、尿痠呈負相關(均P＜0.05).總血脂代謝異常率及各類型血脂代謝異常率均隨BMI水平的升高呈上升趨勢(趨勢檢驗均P＜0.01),各類型血脂代謝異常率在腰圍、血壓、血糖、血尿痠不同組(升高組和非升高組)間比較差異也均有統計學意義(均P＜ 0.05).非條件logistic迴歸分析顯示,在校正年齡和性彆因素後,超重或肥胖、高血壓均是高TC血癥和高LDL-C血癥的危險因素,超重或肥胖、高尿痠血癥是低HDL-C血癥的危險因素,超重或肥胖、高血壓、高血糖和高尿痠血癥均為高TG血癥和總血脂異常的危險因素.結論 城市化社區人群有較高的血脂代謝異常率,超重或肥胖、高血壓、高血糖和高尿痠血癥影響血脂代謝,需加彊人群血脂異常的鑑測和綜閤防治.
목적 료해항주시강간구성시화구역거민혈지상황급상관대사영향인소,위해구역적혈지이상방치제공의거.방법 채용수궤정군추양방법선취3개성시화사구≥18세상주호적거민공2 590례,조사분석불동성별、불동년령조간적혈지대사이상솔;TC、TG、LDL-C、HDL-C수평분별여BMI、요위、수축압、서장압、공복혈당、당화혈홍단백、뇨산수평진행Spearmam상관분석,병채용x2검험、x2추세검험화비조건logistic회귀분석방법분석혈지이상여초중혹비반、고혈압、고혈당、고뇨산혈증적상관성.결과 총혈지대사이상솔60.0％(1 554/2 590),표화솔위57.2％.고TC혈증솔위42.9％(1 111/2 590),표화솔위40.5％,기중변연승고솔위31.7％ (822/2 590),표화솔위30.5％;승고솔위11.2％(289/2 590),표화솔위10.0％.고TG혈증솔위33.0％(855/2 590),표화솔위30.7％,기중변연승고솔위15.3％ (397/2 590),표화솔위14.3％;승고솔위17.7％ (458/2 590),표화솔위16.4％.고LDL-C혈증솔위30.4％(787/2 590),표화솔위28.4％,기중변연승고솔22.9％(594/2 590),표화솔위21.7％;승고솔위7.5％(193/2 590),표화솔6.7％.저HDL-C혈증솔위12.6％(327/2 590),표화솔위12.8％.총혈지대사이상솔급각류형혈지대사이상솔재성별간비교차이균무통계학의의(균P＞0.05).고TC혈증、고TG혈증、고LDL-C혈증、총혈지대사이상솔균수년령적증가이승고(추세검험균P ＜0.01),이저HDL-C혈증솔미수년령이유추세변화(추세검험P＞0.05).Spearmam상관분석결과현시,TC、TG、LDL-C수평균여BMI、요위、수축압、서장압、공복혈당、당화혈홍단백、뇨산수평정정상관(균P＜0.01),이HDL-C수평균여BMI、요위、수축압、서장압、공복혈당、당화혈홍단백、뇨산정부상관(균P＜0.05).총혈지대사이상솔급각류형혈지대사이상솔균수BMI수평적승고정상승추세(추세검험균P＜0.01),각류형혈지대사이상솔재요위、혈압、혈당、혈뇨산불동조(승고조화비승고조)간비교차이야균유통계학의의(균P＜ 0.05).비조건logistic회귀분석현시,재교정년령화성별인소후,초중혹비반、고혈압균시고TC혈증화고LDL-C혈증적위험인소,초중혹비반、고뇨산혈증시저HDL-C혈증적위험인소,초중혹비반、고혈압、고혈당화고뇨산혈증균위고TG혈증화총혈지이상적위험인소.결론 성시화사구인군유교고적혈지대사이상솔,초중혹비반、고혈압、고혈당화고뇨산혈증영향혈지대사,수가강인군혈지이상적감측화종합방치.
Objective To provide rationales for preventing and treating dyslipidemia by understanding the current status of lipids and related metabolic factors.Methods A total of 2 590 permanent residents aged ≥ 18 years were selected by random cluster sampling from three urbanized communities of Sijiqing Street.And the rate of abnormal lipid metabolism was calculated for different ages and genders.Spearman's correlation analyses were conducted for the levels of total cholesterol (TC),total triglyceride (TG),low density lipoprotein-cholesterol (LDL-C),high density lipoprotein-cholesterol (HDL-C),body mass index (BMI),waist circumference (WC),systolic blood pressure (SBP),diastolic blood pressure (DBP),fasting plasma glucose (FPG),glycated hemoglobin (HbA 1 c) and uric acid (UA) levels.Both x2 test and logisic regression were employed to examine the correlations between dyslipidemia and overweight/obesity,hypertension,hyperglycemia and hyperuricemia.Results ① The total rate of abnormal lipid metabolism was 60.0％ (1 554/2 590) with a standardized rate of 57.2％.High TC rate was 42.9％ (1 111/2 590) with a standardized rate of 40.5％.And the edge incremental rate was 31.7％ (822/ 2 590),the standardized rate 30.5％,the incremental rate 11.2％ (289/2 590) and the standardized rate 10.0％.High TG rate was 33.0％ (855/2 590) with a standardized rate of 30.7％.And the edge incremental rate was 15.3％ (397/2 590),the standardized rate 14.3％,the incremental rate 17.7％ (458/2 590) and the standardized rate 16.4％.High LDL-C rate was 30.4％ (787/2 590) with a standardized rate of 28.4％.And the edge incremental rate was 22.9％ (594/2 590),the standardized rate 21.7％,the incremental rate 7.5％ (193/2 590) and the standardized rate 6.7％.Low HDL-C rate was 12.6％ (327/2 590) with a standardized rate of 12.8％.The rates of high TC,high TG,high LDL-C,low HDL-C and abnormal lipid metabolism among gender showed no statistically significant difference (P ＞ 0.05);② For both males & females,high TC rate,high TG rate,high LDL-C rate and total rate of abnormal lipid metabolism increased with age (P ＜ 0.01) while low HDL-C rate did not change with age (P ＞ 0.05);③Spearman's correlation analysis showed that the levels of TC,TG and LDL-C were positively correlated with BMI,WC,SBP,DBP,FBG,HbA1C and UA (all P ＜0.01) while the level of HDL-C had negative correlations with BMI,WC,SBP,DBP,FBG,HbA1 c,and UA (all P ＜ 0.05);④The total rate of abnormal lipid metabolism and various types of abnormal lipid metabolism increased with a rising level of BMI in the upward trend (trend test P ＜ 0.01),various types of abnormal lipid metabolism rate between different groups (elevated & non-elevated) of blood pressure,glucose and uric acid also were statistically significant (all P ＜ 0.05);⑤ Non-conditional logistic regression analysis showed that,after adjusting for age and gender,overweight or obesity and hypertension were risk factors of high TC and high LDL-C;overweight or obesity,hyperuricemia was a risk factor for low HDL-C;overweight or obesity,hypertension,hyperglycemia and hyperuricemia were risk factors for high TG and total abnormal blood lipid.Conclusions Urbanized community groups have a high rate of dyslipidemia.And abnormal lipid metabolism is affected by overweight or obesity,hypertension,hyperglycemia and hyperuricemia.The target population should be regularly monitored and comprehensively controlled.
