CAJ | 학술논문

目的：分析胰腺脂肪含量与肝脏脂肪含量、血清甘油三酯(TG)及胰岛β细胞功能的关系。材料与方法在3.0 T磁共振系统应用单体素点分辨波谱序列(PRESS)对58例初诊2型糖尿病患者和32名无糖尿病志愿者的胰腺和肝脏进行1H MRS扫描，应用SAGE软件测量其脂肪和水的峰下面积，计算胰腺和肝脏脂肪分数。分析胰腺脂肪含量与肝脏脂肪含量、身高体重指数(BMI)、TG、空腹血糖、空腹胰岛素(FINS)、稳态模型胰岛素分泌指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)以及李-Bennett胰岛β细胞功能指数(MBCI)的相关性。结果58例初诊2型糖尿病患者和32名无糖尿病志愿者的平均胰腺脂肪分数分别为(16.09±6.27)%和(14.56±7.97)%，差异无统计学差异(P＞0.05)。其中，32例初诊2型糖尿病患者和全部无糖尿病志愿者成功测量肝脏脂肪分数，平均数值分别为(21.13±14.44)%和(12.43±12.19)%，差异有统计学差异(P=0.006)。相关性分析表明，初诊2型糖尿病患者的胰腺脂肪含量与肝脏脂肪含量、BMI、TG、空腹血糖、FINS、MBCI、HOMA-β及HOMA-IR均无明确相关性(r＜0.15，P＞0.05)，而无糖尿病志愿者的胰腺脂肪含量与肝脏脂肪含量(r=0.502，P=0.003)、TG(r=0.467， P=0.007)及BMI (r=0.362，P=0.042)有中度至低度的相关性。结论初诊2型糖尿病患者的胰腺脂肪含量与肝脏脂肪含量、TG及胰岛β细胞功能不相关。
목적：분석이선지방함량여간장지방함량、혈청감유삼지(TG)급이도β세포공능적관계。재료여방법재3.0 T자공진계통응용단체소점분변파보서렬(PRESS)대58례초진2형당뇨병환자화32명무당뇨병지원자적이선화간장진행1H MRS소묘，응용SAGE연건측량기지방화수적봉하면적，계산이선화간장지방분수。분석이선지방함량여간장지방함량、신고체중지수(BMI)、TG、공복혈당、공복이도소(FINS)、은태모형이도소분비지수(HOMA-β)、이도소저항지수(HOMA-IR)이급리-Bennett이도β세포공능지수(MBCI)적상관성。결과58례초진2형당뇨병환자화32명무당뇨병지원자적평균이선지방분수분별위(16.09±6.27)%화(14.56±7.97)%，차이무통계학차이(P＞0.05)。기중，32례초진2형당뇨병환자화전부무당뇨병지원자성공측량간장지방분수，평균수치분별위(21.13±14.44)%화(12.43±12.19)%，차이유통계학차이(P=0.006)。상관성분석표명，초진2형당뇨병환자적이선지방함량여간장지방함량、BMI、TG、공복혈당、FINS、MBCI、HOMA-β급HOMA-IR균무명학상관성(r＜0.15，P＞0.05)，이무당뇨병지원자적이선지방함량여간장지방함량(r=0.502，P=0.003)、TG(r=0.467， P=0.007)급BMI (r=0.362，P=0.042)유중도지저도적상관성。결론초진2형당뇨병환자적이선지방함량여간장지방함량、TG급이도β세포공능불상관。
Objective: To in vivo quantify the pancreatic fat content in newly diagnosed type 2 diabetes mellitus (T2DM) by applying1H MRS, and investigate its relationships with liver fat content, serum triglyceride (TG) and islet beta-cell function. Materials and Methods: Fifty-eight T2DM subjects and thirty-two volunteers without T2DM were included in this study. All T2DM subjects were newly diagnosed according to the clinical criteria without any therapy. The pancreatic spectroscopy of at least one location (head, body, and tail) and liver spectroscopy at right lobe were acquired by single-voxel PRESS sequence on 3.0 T MR scanner. The pancreas fat content (PFC) and liver fat content (LFC) were calculated in each case.Spearman correlations between PFC and LFC, TG, the body mass index (BMI), the fasting blood-glucose (FBG), the fasting serum insulin (FINS), the homeostasis model assessment of insulin resistance (HOMA-IR), the homeostasis model assessment-β (HOMA-β)and the Lee-Bennett islet beta cell function index (MBCI) were performed in order to visualize their relationships.Results:The mean values of PFC in 58 T2DM subjects and 32 volunteers without T2DM were (16.09±6.27)% and (14.56±7.97)%, respectively, there is no statistically difference (P>0.05). The LFC in 32 T2DM subjects and all volunteers without T2DM was successfully measured, the mean values were (21.13±14.44)% and (12.43±12.19)%, respectively, there was statistically signiifcant differences (P=0.006). Moderate to low correlations were found between PFC and LFC (r=0.502,P=0.003), TG (r=0.467,P=0.007), and BMI (r=0.362,P=0.042) in volunteers without T2DM, but no statistical correlation was found between PFC and LFC, TG, BMI, FBG, FINS, HOMA-IR, HOMA-β, and MBCI (r<0.15,P>0.05) in T2DM subjects.Conclusions:No correlation was found between PFC and LPF, TG, and islet beta-cell function in patients with newly diagnosed T2DM.