中华全科医师杂志
中華全科醫師雜誌
중화전과의사잡지
CHINESE JOURNAL OF GENERAL PRACTITIONERS
2015年
5期
366-369
,共4页
黄斑变性%体层摄影术,光学相干%视网膜电描记术
黃斑變性%體層攝影術,光學相榦%視網膜電描記術
황반변성%체층섭영술,광학상간%시망막전묘기술
Macular degeneration%Tomography,optical coherence%Electroretinography
目的 了解特发性黄斑视网膜前膜(IMEM)患者黄斑区结构与功能改变及其相关性.方法 回顾分析2013年4月至2014年4月经我院收治并确诊的85例单眼IMEM患者的临床资料.将患者的患眼(85眼)作为观察组,正常眼(85眼)作为对照组.对比术前常规眼科检查、光学相干断层扫描技术(OCT)以及多焦视网膜电图(mfERG)检查结果,分析两组黄斑区的结构和功能特征及IMEM黄斑区结构与功能的相关性.结果 观察组术前最佳矫正视力(BCVA)为0.55±0.17,均＜1.0,对照组BCVA为0.92±0.14,观察组BCVA低于对照组,观察组BCVA ＜0.1眼数比对照组多,差异均有统计学意义(t=-15.49,x2=124.46,均P＜0.05).观察组黄斑中心凹厚度(CRT) (322.1±54.3)μm,对照组CRT(210.3 ±47.5)μm,观察组CRT高于对照组,差异有统计学意义(t=14.29,P＜0.05).观察组N1、P1波的平均反应密度分别为(36.7±19.7)和(95.2±24.0) nV/deg2,低于对照组的(42.9±16.3)和(134.8±20.1)nV/deg2,观察组N1、P1波的平均潜伏期分别为(22.0±4.1)和(39.5 ±4.7)ms,高于对照组的(18.7±3.0)和(38.0±3.2)ms,差异均有统计学意义(t值分别为-2.23、-11.66、5.99和2.43,均P＜0.05).观察组CRT与黄斑中心N1、P1波的平均反应密度及潜伏期均无统计学相关性(r值分别为-0.23、-0.35、0.06和-0.04,均P＞0.05);BCVA与CRT成负相关(r=-2.16,P＜0.05).结论 IMEM患眼的黄斑区视网膜结构改变,功能受损,视力下降;患眼视力与CRT成负相关,CRT与黄斑中心mfERG无明显相关性.
目的 瞭解特髮性黃斑視網膜前膜(IMEM)患者黃斑區結構與功能改變及其相關性.方法 迴顧分析2013年4月至2014年4月經我院收治併確診的85例單眼IMEM患者的臨床資料.將患者的患眼(85眼)作為觀察組,正常眼(85眼)作為對照組.對比術前常規眼科檢查、光學相榦斷層掃描技術(OCT)以及多焦視網膜電圖(mfERG)檢查結果,分析兩組黃斑區的結構和功能特徵及IMEM黃斑區結構與功能的相關性.結果 觀察組術前最佳矯正視力(BCVA)為0.55±0.17,均＜1.0,對照組BCVA為0.92±0.14,觀察組BCVA低于對照組,觀察組BCVA ＜0.1眼數比對照組多,差異均有統計學意義(t=-15.49,x2=124.46,均P＜0.05).觀察組黃斑中心凹厚度(CRT) (322.1±54.3)μm,對照組CRT(210.3 ±47.5)μm,觀察組CRT高于對照組,差異有統計學意義(t=14.29,P＜0.05).觀察組N1、P1波的平均反應密度分彆為(36.7±19.7)和(95.2±24.0) nV/deg2,低于對照組的(42.9±16.3)和(134.8±20.1)nV/deg2,觀察組N1、P1波的平均潛伏期分彆為(22.0±4.1)和(39.5 ±4.7)ms,高于對照組的(18.7±3.0)和(38.0±3.2)ms,差異均有統計學意義(t值分彆為-2.23、-11.66、5.99和2.43,均P＜0.05).觀察組CRT與黃斑中心N1、P1波的平均反應密度及潛伏期均無統計學相關性(r值分彆為-0.23、-0.35、0.06和-0.04,均P＞0.05);BCVA與CRT成負相關(r=-2.16,P＜0.05).結論 IMEM患眼的黃斑區視網膜結構改變,功能受損,視力下降;患眼視力與CRT成負相關,CRT與黃斑中心mfERG無明顯相關性.
목적 료해특발성황반시망막전막(IMEM)환자황반구결구여공능개변급기상관성.방법 회고분석2013년4월지2014년4월경아원수치병학진적85례단안IMEM환자적림상자료.장환자적환안(85안)작위관찰조,정상안(85안)작위대조조.대비술전상규안과검사、광학상간단층소묘기술(OCT)이급다초시망막전도(mfERG)검사결과,분석량조황반구적결구화공능특정급IMEM황반구결구여공능적상관성.결과 관찰조술전최가교정시력(BCVA)위0.55±0.17,균＜1.0,대조조BCVA위0.92±0.14,관찰조BCVA저우대조조,관찰조BCVA ＜0.1안수비대조조다,차이균유통계학의의(t=-15.49,x2=124.46,균P＜0.05).관찰조황반중심요후도(CRT) (322.1±54.3)μm,대조조CRT(210.3 ±47.5)μm,관찰조CRT고우대조조,차이유통계학의의(t=14.29,P＜0.05).관찰조N1、P1파적평균반응밀도분별위(36.7±19.7)화(95.2±24.0) nV/deg2,저우대조조적(42.9±16.3)화(134.8±20.1)nV/deg2,관찰조N1、P1파적평균잠복기분별위(22.0±4.1)화(39.5 ±4.7)ms,고우대조조적(18.7±3.0)화(38.0±3.2)ms,차이균유통계학의의(t치분별위-2.23、-11.66、5.99화2.43,균P＜0.05).관찰조CRT여황반중심N1、P1파적평균반응밀도급잠복기균무통계학상관성(r치분별위-0.23、-0.35、0.06화-0.04,균P＞0.05);BCVA여CRT성부상관(r=-2.16,P＜0.05).결론 IMEM환안적황반구시망막결구개변,공능수손,시력하강;환안시력여CRT성부상관,CRT여황반중심mfERG무명현상관성.
Objective To investigate the correlation between macular structural changes and functional outcomes in idiopathic macular epiretinal membranes (IMEM).Methods Clinical data of 85 patients with monocular IMEM admitted from April 2013 to April 2014 were retrospectively analyzed.The diseased eyes(85 eyes)were studied as observation group and the normal eyes (85 eyes)served as control group.The results of routine eye examinations,optical coherence tomography (OCT) and multifocal electroretinography (mfERG) were compared between observation and control groups.Results The preoperative best corrected visual acuity (BCVA) in observation group was lower than that in control group (0.55-± 0.17 vs.0.92 ± 0.14,P ＜ 0.05);the eyes with BCVA ＜ 0.1 in observation group were more than those in control group (P ＜ 0.05).The central retinal thickness (CRT) of observation group was higher than that of control group[(322.1 ±54.3) μm vs.(210.3 ±47.5) μm,t =14.29,P ＜0.05].The average response density of N1 wave and P1 wave in observation group were (36.7 ± 19.7) and (95.2 ±24.0) nV/ deg2,which were lower than those in control group [(42.9 ± 16.3) and (134.8 ± 20.1) nV/deg2;t =-2.23 and-11.66,respectively,P ＜0.05].The latent period of N1 wave and P1 wave in observation group were (22.0 ±4.1) and (39.5 ± 4.7) ms,which were lower than those in control group [(18.7 ± 3.0) and (38.0 ± 3.2) ms;t =5.99 and 2.43,respectively,all P ＜ 0.05].The CRT in observation group was not correlated with average response density of macular center N1,P1 wave and latent period (r =-0.23,-0.35,0.06,-0.04,all P ＞ 0.05).BCVA in observation group was negatively correlated with CRT(r =-2.16,P ＜ 0.05).Conclusions The central retinal thickness is negatively correlated with the best corrected visual acuity,but not correlated with center mfERG in patients with IMEM.
