中华全科医师杂志
中華全科醫師雜誌
중화전과의사잡지
CHINESE JOURNAL OF GENERAL PRACTITIONERS
2015年
5期
370-373
,共4页
痤疮,寻常%光疗法%丙酸杆菌,痤疮%投药,局部
痤瘡,尋常%光療法%丙痠桿菌,痤瘡%投藥,跼部
좌창,심상%광요법%병산간균,좌창%투약,국부
Acne vulgaris%Color therapy%Propionibacterium%Administration,topical
目的 了解痤疮涂膜剂和红、蓝光照射联合治疗中、重度痤疮的疗效及安全性.方法 对我院门诊2012年3月至2014年7月诊治的547例中、重度痤疮患者,按就诊顺序循环将患者分为3个治疗组,观察组183例及对照1组182例、对照2组182例,3组中中、重度患者各为130和53例、130和52例,129和53例.观察组采用痤疮涂膜剂和红、蓝光照射联合治疗,红光和蓝光每周各照射1次、间隔3d,痤疮涂膜剂每日应用1次;对照1组仅用痤疮涂膜剂治疗,每日1次;对照2组仅行红、蓝光交替照射治疗,每周各1次,3组均治疗6周.记录治疗前和治疗2、4、6周后的皮损数目,治疗后第10周评价疗效.结果 3组患者治疗后皮损数均较治疗前有不同程度的减少,治疗6周时减少最明显,3组中观察组皮损数减少最为明显.中度痤疮的总有效率,观察组为84.6％ (110/130),对照1组为58.5％ (76/130),对照2组为51.9％ (67/129),观察组与对照1、2组比较,差异均有统计学意义(x2值分别为21.836和31.955,均P＜0.01);重度痤疮的总有效率,观察组为84.9％ (45/53),对照1组为57.7％(30/52),对照2组为56.6％ (30/53),观察组与对照1、2组比较,差异均有统计学意义(x2值分别为9.525和10.258,均P＜0.01).观察组治疗中共有20例(10.9％)出现不良反应,表现为红斑、瘙痒、灼热和刺痛感,对照1、2组出现不良反应者分别为14和22例(7.7％和12.1％),均能耐受.结论 痤疮涂膜剂和红、蓝光交替照射联合治疗中、重度痤疮,比采用单一治疗方案效果好,且安全.
目的 瞭解痤瘡塗膜劑和紅、藍光照射聯閤治療中、重度痤瘡的療效及安全性.方法 對我院門診2012年3月至2014年7月診治的547例中、重度痤瘡患者,按就診順序循環將患者分為3箇治療組,觀察組183例及對照1組182例、對照2組182例,3組中中、重度患者各為130和53例、130和52例,129和53例.觀察組採用痤瘡塗膜劑和紅、藍光照射聯閤治療,紅光和藍光每週各照射1次、間隔3d,痤瘡塗膜劑每日應用1次;對照1組僅用痤瘡塗膜劑治療,每日1次;對照2組僅行紅、藍光交替照射治療,每週各1次,3組均治療6週.記錄治療前和治療2、4、6週後的皮損數目,治療後第10週評價療效.結果 3組患者治療後皮損數均較治療前有不同程度的減少,治療6週時減少最明顯,3組中觀察組皮損數減少最為明顯.中度痤瘡的總有效率,觀察組為84.6％ (110/130),對照1組為58.5％ (76/130),對照2組為51.9％ (67/129),觀察組與對照1、2組比較,差異均有統計學意義(x2值分彆為21.836和31.955,均P＜0.01);重度痤瘡的總有效率,觀察組為84.9％ (45/53),對照1組為57.7％(30/52),對照2組為56.6％ (30/53),觀察組與對照1、2組比較,差異均有統計學意義(x2值分彆為9.525和10.258,均P＜0.01).觀察組治療中共有20例(10.9％)齣現不良反應,錶現為紅斑、瘙癢、灼熱和刺痛感,對照1、2組齣現不良反應者分彆為14和22例(7.7％和12.1％),均能耐受.結論 痤瘡塗膜劑和紅、藍光交替照射聯閤治療中、重度痤瘡,比採用單一治療方案效果好,且安全.
목적 료해좌창도막제화홍、람광조사연합치료중、중도좌창적료효급안전성.방법 대아원문진2012년3월지2014년7월진치적547례중、중도좌창환자,안취진순서순배장환자분위3개치료조,관찰조183례급대조1조182례、대조2조182례,3조중중、중도환자각위130화53례、130화52례,129화53례.관찰조채용좌창도막제화홍、람광조사연합치료,홍광화람광매주각조사1차、간격3d,좌창도막제매일응용1차;대조1조부용좌창도막제치료,매일1차;대조2조부행홍、람광교체조사치료,매주각1차,3조균치료6주.기록치료전화치료2、4、6주후적피손수목,치료후제10주평개료효.결과 3조환자치료후피손수균교치료전유불동정도적감소,치료6주시감소최명현,3조중관찰조피손수감소최위명현.중도좌창적총유효솔,관찰조위84.6％ (110/130),대조1조위58.5％ (76/130),대조2조위51.9％ (67/129),관찰조여대조1、2조비교,차이균유통계학의의(x2치분별위21.836화31.955,균P＜0.01);중도좌창적총유효솔,관찰조위84.9％ (45/53),대조1조위57.7％(30/52),대조2조위56.6％ (30/53),관찰조여대조1、2조비교,차이균유통계학의의(x2치분별위9.525화10.258,균P＜0.01).관찰조치료중공유20례(10.9％)출현불량반응,표현위홍반、소양、작열화자통감,대조1、2조출현불량반응자분별위14화22례(7.7％화12.1％),균능내수.결론 좌창도막제화홍、람광교체조사연합치료중、중도좌창,비채용단일치료방안효과호,차안전.
Objective To evaluate the efficacy of combined red and blue light therapy with acne film coating in treatment of moderate and severe acne.Methods Totally 547 patients with moderate or severe acne were enrolled in the study from March 2012 to July 2014.Using open control,according to the cycle of time sequence will patients were divided into three groups:183 patients (study group) were received alternatively red and blue light therapy twice a week,and acre film coating was applied once a day;182 patients in control group 1 received film coating alone and another 182 patients (control group 2) received light therapy alone.The treatment lasted for 6 weeks in all three groups.The numbers of skin lesions were recorded before and 2,4,6 w after treatment,and the curative effect was evaluated 10 w after treatment.Results The number of skin lesion were significantly reduced 6w after treatment in all three groups,that for study group was most markedly.For patients with moderate acne,the total effective rates in study group and in control groups 1 and 2 were 84.6％ (110/130),58.5％ (76/130) and 51.9％ (67/129),respectively (x2 =21.836,and 31.955,P ＜0.01).For patients with severe acne the total effective rates in study group and in control groups 1 and 2 were 84.9％ (45/53),57.7％ (30/52) and 56.6％ (30/53),respectively (x2 =9.525 and 10.258,P ＜0.01).There are 20 cases in observation group therapy for different degree of erythema,itching,burning,tingling,incidence of side effects was 10.9％ (20/183),control group 1 and 2 were 7.1％ (14/182),12.1％ (22/182),are tolerated.Conclusion The combination of red/blue light therapy with acne film coating is more effective than the application of single method alone for patients with moderate or severe acne.
