CAJ | 학술논문

目的：探讨T2DM合并非酒精性脂肪性肝病（NAFLD）血糖波动与非酒精性脂肪性肝病肝纤维化评分（NAFLDFS）的相关性。方法根据NAFLDFS结果将107例T2DM合并NAFLD患者分为肝纤维化低危组（NAFLDFS＜0.676）和肝纤维化组（NAFLDFS≥0.676），比较两组间血糖波动等指标，并行Logistic回归分析。结果两组病程、BMI、WC、WHR、HbA1 c、HDL‐C及平均血糖波动幅度（MAGE）比较差异均有统计学意义（ P＜0.05或 P＜0.01）。 Logistic 回归分析发现，MAGE 是NAFLDFS的独立危险因素（OR＝2.108，95％ CI：1.088～4.085）。结论 T2DM 合并 NAFLD患者MAGE与NAFLDFS独立相关。
목적：탐토T2DM합병비주정성지방성간병（NAFLD）혈당파동여비주정성지방성간병간섬유화평분（NAFLDFS）적상관성。방법근거NAFLDFS결과장107례T2DM합병NAFLD환자분위간섬유화저위조（NAFLDFS＜0.676）화간섬유화조（NAFLDFS≥0.676），비교량조간혈당파동등지표，병행Logistic회귀분석。결과량조병정、BMI、WC、WHR、HbA1 c、HDL‐C급평균혈당파동폭도（MAGE）비교차이균유통계학의의（ P＜0.05혹 P＜0.01）。 Logistic 회귀분석발현，MAGE 시NAFLDFS적독립위험인소（OR＝2.108，95％ CI：1.088～4.085）。결론 T2DM 합병 NAFLD환자MAGE여NAFLDFS독립상관。
Objective To investigate the association between glucose variability and nonalcoholic fatty liver disease fibrosis score (NAFLDFS ) in type 2 diabetes mellitus (T2DM ) patients with nonalcoholic fatty liver disease(NAFLD). Methods According to the scores of NAFLDFS ,a total of 107 subjects were divided into two groups :with low risk of liver fibrosis (NAFLDFS<0.676) ,with liver fibrosis (NAFLDFS≥0.676).Glucose variability and related indices were compared. Logistic regression analysis was used to examine the risk factors for liver fibrosis. Results There were significant differences in the course of disease ,body mass index (BMI) ,waist circumference (WC) ,waist‐hip ratio (WHR) ,human glycated hemoglobin A1c (HbA1c) ,high density lipoprotein cholesterol (HDL‐C) ,and mean amplitude of glycemic excursions(MAGE) between two groups(P< 0.05 or P< 0.01). Logistic regression analysis showed that MAGE was the independent risk factor for NAFLDFS (OR=2.108 ,95% CI:1.088~4.085). Conclusion Glucose variability is significantly related to NAFLDFS in T 2DM patients with NAFLD.