中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2015年
5期
409-411
,共3页
赵希璐%岳晓菲%杨勇%王慧丽%王志达%齐秀英
趙希璐%嶽曉菲%楊勇%王慧麗%王誌達%齊秀英
조희로%악효비%양용%왕혜려%왕지체%제수영
糖尿病 ,2型%甲状腺功能减退%相关因素
糖尿病 ,2型%甲狀腺功能減退%相關因素
당뇨병 ,2형%갑상선공능감퇴%상관인소
Diabetes mellitus,type 2%Hypothyroidism%Correlative factor
目的：探讨T2DM患者合并甲状腺功能减退（下称“甲减”）的相关因素。方法选取T2DM合并甲减患者100例作为甲减组，甲状腺功能正常的T2DM患者1031例作为T2DM组，检测两组的一般资料及生化指标。结果甲减组年龄[（61.03±10.93）vs（54.89±11.17）岁]、女性比例[67（67.0％）vs430（41.7％）]、T2DM病程[10.0（4.0，16.0）vs6.0（2.0，11.0）年]、SBP[（141.55±20.24）vs（136.52±19.46）mmHg]、促甲状腺激素（TSH）[5.88（4.94，9.26）vs1.40（0.97，2.02）μU／ml]、胰岛素治疗者比例[61（61.0％）vs456（44.2％）]和甲状腺过氧化物酶抗体（TPO‐Ab）阳性率[45（45.0％）vs111（10.8％）]较T2DM组高，DBP[（79.45±10.15）vs（82.16±11.14）mmHg]、HbA1c[7.9（6.9，9.3）％vs8.4（7.2，10.0）％]、游离三碘甲状腺原氨酸（FT3）[3.94（3.39，4.32）vs4.43（4.01，4.86）pmol／L]、游离甲状腺素（FT4）[（13.97±3.22）vs（17.04±2.13）pmol／L]和吸烟者比例[14（14.0％）vs363（35.2％）]较T2DM组低（P＜0.05或P＜0.01）。Logistic多元回归分析结果显示，年龄、吸烟、胰岛素治疗和TPO‐Ab是T2DM患者合并甲减的影响因素。结论年龄、吸烟和TPO‐Ab是T2DM患者合并甲减的影响因素，胰岛素治疗可能与T2DM患者合并甲减有关。
目的：探討T2DM患者閤併甲狀腺功能減退（下稱“甲減”）的相關因素。方法選取T2DM閤併甲減患者100例作為甲減組，甲狀腺功能正常的T2DM患者1031例作為T2DM組，檢測兩組的一般資料及生化指標。結果甲減組年齡[（61.03±10.93）vs（54.89±11.17）歲]、女性比例[67（67.0％）vs430（41.7％）]、T2DM病程[10.0（4.0，16.0）vs6.0（2.0，11.0）年]、SBP[（141.55±20.24）vs（136.52±19.46）mmHg]、促甲狀腺激素（TSH）[5.88（4.94，9.26）vs1.40（0.97，2.02）μU／ml]、胰島素治療者比例[61（61.0％）vs456（44.2％）]和甲狀腺過氧化物酶抗體（TPO‐Ab）暘性率[45（45.0％）vs111（10.8％）]較T2DM組高，DBP[（79.45±10.15）vs（82.16±11.14）mmHg]、HbA1c[7.9（6.9，9.3）％vs8.4（7.2，10.0）％]、遊離三碘甲狀腺原氨痠（FT3）[3.94（3.39，4.32）vs4.43（4.01，4.86）pmol／L]、遊離甲狀腺素（FT4）[（13.97±3.22）vs（17.04±2.13）pmol／L]和吸煙者比例[14（14.0％）vs363（35.2％）]較T2DM組低（P＜0.05或P＜0.01）。Logistic多元迴歸分析結果顯示，年齡、吸煙、胰島素治療和TPO‐Ab是T2DM患者閤併甲減的影響因素。結論年齡、吸煙和TPO‐Ab是T2DM患者閤併甲減的影響因素，胰島素治療可能與T2DM患者閤併甲減有關。
목적：탐토T2DM환자합병갑상선공능감퇴（하칭“갑감”）적상관인소。방법선취T2DM합병갑감환자100례작위갑감조，갑상선공능정상적T2DM환자1031례작위T2DM조，검측량조적일반자료급생화지표。결과갑감조년령[（61.03±10.93）vs（54.89±11.17）세]、녀성비례[67（67.0％）vs430（41.7％）]、T2DM병정[10.0（4.0，16.0）vs6.0（2.0，11.0）년]、SBP[（141.55±20.24）vs（136.52±19.46）mmHg]、촉갑상선격소（TSH）[5.88（4.94，9.26）vs1.40（0.97，2.02）μU／ml]、이도소치료자비례[61（61.0％）vs456（44.2％）]화갑상선과양화물매항체（TPO‐Ab）양성솔[45（45.0％）vs111（10.8％）]교T2DM조고，DBP[（79.45±10.15）vs（82.16±11.14）mmHg]、HbA1c[7.9（6.9，9.3）％vs8.4（7.2，10.0）％]、유리삼전갑상선원안산（FT3）[3.94（3.39，4.32）vs4.43（4.01，4.86）pmol／L]、유리갑상선소（FT4）[（13.97±3.22）vs（17.04±2.13）pmol／L]화흡연자비례[14（14.0％）vs363（35.2％）]교T2DM조저（P＜0.05혹P＜0.01）。Logistic다원회귀분석결과현시，년령、흡연、이도소치료화TPO‐Ab시T2DM환자합병갑감적영향인소。결론년령、흡연화TPO‐Ab시T2DM환자합병갑감적영향인소，이도소치료가능여T2DM환자합병갑감유관。
Objective To explore the correlates of hypothyroidism in T2DM patients. Methods A case‐control study was conducted in patients with T 2DM. They were divided into two groups :T2DM+hypothyroidism patient group and T2DM + euthyroid patient group. Logistic multivariate regression was used to analyze correlates of hypothyroidism in T 2DM patients. Results Age [(61.03 ± 10.93 ) vs (54.89 ± 11.17)years] ,female [67(67.0% ) vs 430(41.7% )] ,T2DM duration [10.0(4.0 ,16.0) vs 6.0 (2.0 ,11.0)years] ,SBP [(141.55 ± 20.24) vs (136.52 ± 19.46)mmHg] ,TSH [5.88(4.94 ,9.26) vs 1.40(0.97 ,2.02 )μU/ml] ,insulin therapy [61 (61.0% ) vs 456 (44.2% )] and positive TPO‐Ab [45 (45.0% ) vs 111(10.8% )] were significantly higher in hypothyroidism group than in T2DM group ,DBP [(79.45 ± 10.15) vs (82.16 ± 11.14)mmHg] ,HbA1c [7.9(6.9 ,9.3)% vs 8.4(7.2 ,10.0)% ] ,FT3 [3.94 (3.39 ,4.32) vs 4.43(4.01 ,4.86)pmol/L] ,FT4 [(13.97 ± 3.22) vs (17.04 ± 2.13)pmol/L] and smoking [14(14.0% ) vs 363(35.2% )] were significantly lower in hypothyroidism group than in T 2DM group (P<0.05 or P< 0.01) .The multivariate logistic regression analysis showed that ,age ,smoking ,insulin therapy and TPO‐Ab were the correlative factors of hypothyroidism in T 2DM patients. Conclusion Age ,smoking and TPO‐Ab were related to hypothyroidism in T2DM patients. Insulin therapy may also be relate to hypothyroidism in T 2DM patients.
