世界最新医学信息文摘（连续型电子期刊）
世界最新醫學信息文摘（連續型電子期刊）
세계최신의학신식문적（련속형전자기간）
World Latest Medicine Information
2015年
19期
23-24,27
,共3页
张荣天%雷鸣%刘伟%李秀霞%翁立新
張榮天%雷鳴%劉偉%李秀霞%翁立新
장영천%뢰명%류위%리수하%옹립신
缺血再灌注损伤%缺氧诱导因子%细胞外信号调节激酶
缺血再灌註損傷%缺氧誘導因子%細胞外信號調節激酶
결혈재관주손상%결양유도인자%세포외신호조절격매
Ischemia/reperfusion injury%Hypoxia inducible factor-1%extracellular signal-regulated protein kinase
缺血再灌注(ischemia/reperfusion，I/R)损伤是临床上很多种疾病的共同发病基础，是近年来的研究热点。缺氧诱导因子1(hypoxia inducible factor-1,HIF-1)，是一种在缺氧条件下广泛存在于哺乳动物和人体内的转录因子。细胞外信号调节激酶(extracellular signal-regulated protein kinase,ERK)是丝裂原活化蛋白激酶(mitogen-actived Protein kinase,MAPK)家族的最重要的转导通路之。近年来关于HIF-1/ERK信号的研究较多，本文就HIF-1/ERK信号通路在缺血再灌注损伤组织中的表达研究作一综述。
缺血再灌註(ischemia/reperfusion，I/R)損傷是臨床上很多種疾病的共同髮病基礎，是近年來的研究熱點。缺氧誘導因子1(hypoxia inducible factor-1,HIF-1)，是一種在缺氧條件下廣汎存在于哺乳動物和人體內的轉錄因子。細胞外信號調節激酶(extracellular signal-regulated protein kinase,ERK)是絲裂原活化蛋白激酶(mitogen-actived Protein kinase,MAPK)傢族的最重要的轉導通路之。近年來關于HIF-1/ERK信號的研究較多，本文就HIF-1/ERK信號通路在缺血再灌註損傷組織中的錶達研究作一綜述。
결혈재관주(ischemia/reperfusion，I/R)손상시림상상흔다충질병적공동발병기출，시근년래적연구열점。결양유도인자1(hypoxia inducible factor-1,HIF-1)，시일충재결양조건하엄범존재우포유동물화인체내적전록인자。세포외신호조절격매(extracellular signal-regulated protein kinase,ERK)시사렬원활화단백격매(mitogen-actived Protein kinase,MAPK)가족적최중요적전도통로지。근년래관우HIF-1/ERK신호적연구교다，본문취HIF-1/ERK신호통로재결혈재관주손상조직중적표체연구작일종술。
Ischemia/reperfusion(I/R) injury is the common basis as the onset of many kinds of disease, clinical is the research hotspot in recent years. Hypoxia inducing factor 1(HIF-1), is a kind of oxygen conditions exist widely in mammals and the transcription factors in the human body. Extracellular signal regulating kinase (ERK) is silk crack the original activated protein kinase (mitogen-actived protein kinase, MAPK) family is the most important transduction pathways. In recent years, research on HIF-1/ERK signal is more, in this paper,theHIF-1/ERK signaling pathway in the tissue of ischemia-reperfusion injury expression research.
