中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
11期
63-63,101
,共2页
脑小血管病%弥散张量成像%认知功能障碍
腦小血管病%瀰散張量成像%認知功能障礙
뇌소혈관병%미산장량성상%인지공능장애
Cerebral small vessel disease%Diffusion tensor imaging%Cognitive dysfunction
目的：探讨脑小血管病患者MR弥散张量成像的改变以及与认知功能障碍间的关系。方法选取我院接受检查的小脑血管疾病患者70例，根据有无认知障碍分为非痴呆认知功能障碍（VCIND）组39例和认知功能正常（NCI）组31例。对患者进行蒙特利尔认知评估（MoCA）及MRI检查，并对弥散张力成像（DTI）进行处理，显示表观弥散系数图（ADC）以及各向异性分数图（FA），分析MoCA与DTI的相关性。结果 VCIND组MoCA量表评分（17.54±4.31）分，NCI组为（24.01±2.02）分；VCIND组双侧半卵圆中心、双侧额叶、双侧丘脑以及左侧尾状核 FA 值明显低于 NCI组，VCIND 组左侧尾状核ADC值明显高于NCI组，差异有统计学意义（P＜0.05）。双侧半卵圆中心、双侧额叶以及左侧尾状核FA值与MoCA呈正相关（P＜0.05）。结论脑小血管疾病患者认知功能障碍与DTI的FA值呈正相关。
目的：探討腦小血管病患者MR瀰散張量成像的改變以及與認知功能障礙間的關繫。方法選取我院接受檢查的小腦血管疾病患者70例，根據有無認知障礙分為非癡呆認知功能障礙（VCIND）組39例和認知功能正常（NCI）組31例。對患者進行矇特利爾認知評估（MoCA）及MRI檢查，併對瀰散張力成像（DTI）進行處理，顯示錶觀瀰散繫數圖（ADC）以及各嚮異性分數圖（FA），分析MoCA與DTI的相關性。結果 VCIND組MoCA量錶評分（17.54±4.31）分，NCI組為（24.01±2.02）分；VCIND組雙側半卵圓中心、雙側額葉、雙側丘腦以及左側尾狀覈 FA 值明顯低于 NCI組，VCIND 組左側尾狀覈ADC值明顯高于NCI組，差異有統計學意義（P＜0.05）。雙側半卵圓中心、雙側額葉以及左側尾狀覈FA值與MoCA呈正相關（P＜0.05）。結論腦小血管疾病患者認知功能障礙與DTI的FA值呈正相關。
목적：탐토뇌소혈관병환자MR미산장량성상적개변이급여인지공능장애간적관계。방법선취아원접수검사적소뇌혈관질병환자70례，근거유무인지장애분위비치태인지공능장애（VCIND）조39례화인지공능정상（NCI）조31례。대환자진행몽특리이인지평고（MoCA）급MRI검사，병대미산장력성상（DTI）진행처리，현시표관미산계수도（ADC）이급각향이성분수도（FA），분석MoCA여DTI적상관성。결과 VCIND조MoCA량표평분（17.54±4.31）분，NCI조위（24.01±2.02）분；VCIND조쌍측반란원중심、쌍측액협、쌍측구뇌이급좌측미상핵 FA 치명현저우 NCI조，VCIND 조좌측미상핵ADC치명현고우NCI조，차이유통계학의의（P＜0.05）。쌍측반란원중심、쌍측액협이급좌측미상핵FA치여MoCA정정상관（P＜0.05）。결론뇌소혈관질병환자인지공능장애여DTI적FA치정정상관。
Objective To analyze and discuss the relationship between cerebral small vessel disease in patients with MR diffusion tensor imaging changes and cognitive dysfunction.Methods 70 patients with cerebella vascular disease examined in our hospital were divided into non‐dementia cognitive impairment (VCIND) group(n=39) and normal cognitive function (NCI) group (n=31) according to the presence or absence of cognitive impairment. Patients adopted Montreal Cognitive Assessment (MoCA) and MRI inspection ,and diffusion tensor image (DTI) was processed ,we displayed the apparent diffusion coefficient map (ADC) and fractional anisotropy map (FA) ,and analyzed the correlation between MoCA and the DTI. Results MoCA scale in VCIND group was 17.54 ± 4.31 ,which was 24.01 ± 2.02 in NCI group. The FA values in bilateral centrum ovule ,bi‐lateral frontal ,bilateral caudate nucleus of the thalamus and the left of VCIND group were significantly lower than those of NCI group ,the ADC in left caudate nucleus of VCIND group was significantly higher than that of NCI group ,the differences were statistically significant (P<0.05). The FA values in bilateral semi‐oval center ,bilateral frontal lobe and the left caudate nucle‐us were positively correlated to MoCA (P<0.05).Conclusion The cognitive dysfunction in patients with cerebral small vessel disease is positively correlated to FA values in DTI.
