CAJ | 학술논문

目的：研究3种双黄膏剂中黄芩苷在蛇蜕、小鼠腹皮的经皮扩散情况并对结果进行分析比较。方法：使用智能透皮试验仪对双黄冰凝胶（A）、双黄冰乳膏（B）、双黄乳膏（C）3种膏剂进行体外经皮扩散实验，测定黄芩苷的累积透过量和经皮扩散速率。结果：小鼠腹皮的累积透过量及经皮扩散速率均明显高于蛇蜕（ P＜0．01）。对于蛇蜕，各时间点A的累积透过量及经皮扩散率高于B、C（ P＜0．01），而B与C相比差异无统计学意义；对于小鼠腹皮，3种软膏累积透过量和经皮扩散率均无统计学意义。结论：采用不同皮肤会造成实验结果的不同。对于可增加角质层水合作用的凝胶剂，蛇蜕灵敏度高，干扰因素少，结果稳定。
목적：연구3충쌍황고제중황금감재사세、소서복피적경피확산정황병대결과진행분석비교。방법：사용지능투피시험의대쌍황빙응효（A）、쌍황빙유고（B）、쌍황유고（C）3충고제진행체외경피확산실험，측정황금감적루적투과량화경피확산속솔。결과：소서복피적루적투과량급경피확산속솔균명현고우사세（ P＜0．01）。대우사세，각시간점A적루적투과량급경피확산솔고우B、C（ P＜0．01），이B여C상비차이무통계학의의；대우소서복피，3충연고루적투과량화경피확산솔균무통계학의의。결론：채용불동피부회조성실험결과적불동。대우가증가각질층수합작용적응효제，사세령민도고，간우인소소，결과은정。
Objective:To study the transdermal diffusion of baicalin in three Shanghuang Ointment and compare the effect of dif -ferent skin and ointment bases on diffusion .Methods:Intelligent transdermal test instrument was used to determine the cumulative permeating amounts of baicalin from Shanghuang Carbomer gel ( A) , Shanghuang Cream with borneol ( B) and without borneol ( C) . Then diffusion rate could be calculated .Results:the cumulative permeating amounts and transdermal diffusion rate on mice abdo-men skin were significantly higher than those on snake slough ( P<0.01 ) .On snake slough , the cumulative permeating amounts and transdermal diffusion rate of baicalin in cream A was significantly higher than cream B and C ( P<0.01 ,0.01 ) .The difference of the cumulative permeating amounts between two creams was not significant on mice skin .Conclusion:Different skin will make the different outcome .Shanghuang Carbomer gel can soften cuticles , and snake slough is superior to mice skin because of its high sensitivity, less interferences and excellent stability .