CAJ | 학술논문

目的：比较含替诺福韦（TDF）或含齐多夫定（AZT）的2种高效抗逆转录病毒治疗（HAART）方案的疗效和耐药情况。方法：回顾收集2010年10月至2013年11月接受2种不同组合HAART方案治疗的艾滋病患者共235例，其中AZT组133例，TDF组102例，比较2组治疗12个月后CD4＋T淋巴细胞计数上升的平均值及上升幅度、病毒学失败及耐药情况。结果：2组基线 CD4＋T 淋巴细胞计数、男女比例、年龄、感染方式等具有可比性；2组治疗12个月 CD4＋T 淋巴细胞计数的平均值以及 CD4＋T 淋巴细胞计数的上升幅度比较差异无显著性（P ＞0．05）；病毒学失败3例均发生在 AZT 组，但2组比较差异无统计学意义（P ＞0．05）；AZT 组有1例发生核苷类似物相关突变（TAMs）并对 AZT 高度耐药。结论：2种 HAART 方案对艾滋病治疗的免疫学效果相当，在病毒学方面，含 AZT 组出现2．2％的失败率，但尚未能证明与 AZT 有直接关系。
목적：비교함체낙복위（TDF）혹함제다부정（AZT）적2충고효항역전록병독치료（HAART）방안적료효화내약정황。방법：회고수집2010년10월지2013년11월접수2충불동조합HAART방안치료적애자병환자공235례，기중AZT조133례，TDF조102례，비교2조치료12개월후CD4＋T림파세포계수상승적평균치급상승폭도、병독학실패급내약정황。결과：2조기선 CD4＋T 림파세포계수、남녀비례、년령、감염방식등구유가비성；2조치료12개월 CD4＋T 림파세포계수적평균치이급 CD4＋T 림파세포계수적상승폭도비교차이무현저성（P ＞0．05）；병독학실패3례균발생재 AZT 조，단2조비교차이무통계학의의（P ＞0．05）；AZT 조유1례발생핵감유사물상관돌변（TAMs）병대 AZT 고도내약。결론：2충 HAART 방안대애자병치료적면역학효과상당，재병독학방면，함 AZT 조출현2．2％적실패솔，단상미능증명여 AZT 유직접관계。
Objective To compare the efficacy of highly active anti-retroviral treatment (HAART) with and with AZT. Methods Data of 235 HIV patients accepted from Oct. 2010 to Nov. 2013 who took AZT (133) or TDF (102) containing regimen as first-line HAART are analyzed retrospectively. CD4+ T cell counts acted as the base line after 12 months of HAART. Increase in CD4+ T cell count number after the HAART, virological failures and drug resistance were compared between the two groups. Results The two groups had comparable baseline CD4+T cell count, gender ratio, and HIV transmision mode; after 12 months of HARRT, no statistically differences were found between the two groups with regard to CD4 + T cell count and increase in CD4+ T cell count after the 12-month HAART (P > 0.05); AZT-containing group had more virological failure (3/0). Meanwhile AZT-containing group had one thymidine analog mutation (TAMs) which confers resistance to AZT (P > 0.05 for both). Conculsion The two HAARTs have same immunological effects; AZT-containing group exhibits 2.2% viralogial failure, but its direct relationship with AZT has not been confirmed.