中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
11期
3-5,6
,共4页
缺血性脑血管病%脑微出血%相关因素%认知功能
缺血性腦血管病%腦微齣血%相關因素%認知功能
결혈성뇌혈관병%뇌미출혈%상관인소%인지공능
Ischemic cerebral vascular disease%Cerebral microbleeds%Related factors%Cognitive function
目的分析缺血性脑血管病（ICVD）合并脑微出血（CMBs）的相关因素及对认知功能的影响。方法选取240例ICVD患者为研究对象，根据是否合并CMBs分为CMBs组和非CMBs组，分别纳入62例和178例患者，应用简易精神状况检查表（MMSE）和蒙特利尔认知评估量表（MoCA）评估患者的认知功能。结果 CMBs组患者的年龄、合并高血压比例、脑白质疏松（LA）比例、腔隙性梗死（LI）比例和既往卒中史比例均显著高于非CMBs组患者（P＜0.05），高龄（OR＝1.376）、合并高血压（OR＝3.965）、合并LI（OR＝3.562）是ICVD患者合并CMBs的危险因素（P＜0.05）；CMBs组MMSE总分、MoCA总分和视空间／执行、注意、延迟回忆等评分均显著低于无CMBs组（P＜0.05），累及皮层‐皮层下CMBs患者的MMSE总分、MoCA总分及视空间／执行、注意、语言、延迟回忆等评分均显著低于无累及皮层‐皮层下CMBs患者（P＜0.05）。结论 ICVD患者合并CMBs的发病与多种因素具有相关性，可导致患者出现显著的认知功能障碍，可能与累及皮层‐皮层下CMBs病灶具有相关性。
目的分析缺血性腦血管病（ICVD）閤併腦微齣血（CMBs）的相關因素及對認知功能的影響。方法選取240例ICVD患者為研究對象，根據是否閤併CMBs分為CMBs組和非CMBs組，分彆納入62例和178例患者，應用簡易精神狀況檢查錶（MMSE）和矇特利爾認知評估量錶（MoCA）評估患者的認知功能。結果 CMBs組患者的年齡、閤併高血壓比例、腦白質疏鬆（LA）比例、腔隙性梗死（LI）比例和既往卒中史比例均顯著高于非CMBs組患者（P＜0.05），高齡（OR＝1.376）、閤併高血壓（OR＝3.965）、閤併LI（OR＝3.562）是ICVD患者閤併CMBs的危險因素（P＜0.05）；CMBs組MMSE總分、MoCA總分和視空間／執行、註意、延遲迴憶等評分均顯著低于無CMBs組（P＜0.05），纍及皮層‐皮層下CMBs患者的MMSE總分、MoCA總分及視空間／執行、註意、語言、延遲迴憶等評分均顯著低于無纍及皮層‐皮層下CMBs患者（P＜0.05）。結論 ICVD患者閤併CMBs的髮病與多種因素具有相關性，可導緻患者齣現顯著的認知功能障礙，可能與纍及皮層‐皮層下CMBs病竈具有相關性。
목적분석결혈성뇌혈관병（ICVD）합병뇌미출혈（CMBs）적상관인소급대인지공능적영향。방법선취240례ICVD환자위연구대상，근거시부합병CMBs분위CMBs조화비CMBs조，분별납입62례화178례환자，응용간역정신상황검사표（MMSE）화몽특리이인지평고량표（MoCA）평고환자적인지공능。결과 CMBs조환자적년령、합병고혈압비례、뇌백질소송（LA）비례、강극성경사（LI）비례화기왕졸중사비례균현저고우비CMBs조환자（P＜0.05），고령（OR＝1.376）、합병고혈압（OR＝3.965）、합병LI（OR＝3.562）시ICVD환자합병CMBs적위험인소（P＜0.05）；CMBs조MMSE총분、MoCA총분화시공간／집행、주의、연지회억등평분균현저저우무CMBs조（P＜0.05），루급피층‐피층하CMBs환자적MMSE총분、MoCA총분급시공간／집행、주의、어언、연지회억등평분균현저저우무루급피층‐피층하CMBs환자（P＜0.05）。결론 ICVD환자합병CMBs적발병여다충인소구유상관성，가도치환자출현현저적인지공능장애，가능여루급피층‐피층하CMBs병조구유상관성。
Objective To analyze cognitive function and the related factors of patients with ischemic cerebral vascular dis‐ease (ICVD) complicated with cerebral microbleeds (CMBs). Methods 240 cases of ICVD patients were selected as the re‐search objects and were divided into CMBs group and non CMBs group according to whether complicated with CMBs. 62 pa‐tients and 178 patients were included respectively. Mini Mental State Examination (MMSE) and Montreal cognitive assessment scale (MoCA) were applied to evaluate and compare the cognitive function of the patients.Results The age and proportions of patients with hypertension ,leukoaraiosis(LA) ,lacunar Infarction (LI) ,a history of previous stroke in CMBs group were sig‐nificantly higher than those in non CMBs group (P<0.05). The age (OR=1.376) ,hypertension (OR=3.965) ,and LI (OR=3.562) were the risk factors for the incidence of ICVD patients complicated with CMBs (P< 0.05). The total score of MMSE ,the total score of MoCA score and the scores of visuospatial/executive ,attention ,delayed memory items of patients in CMBs group were significantly lower than those of the patients in non CMBs group (P<0.05). The total score of MMSE ,the total score of MoCA score and the scores of visuospatial/executive ,attention ,language ,delayed memory items of patients with CMBs involving the cortico subcortical areas were significantly lower than those without involving CMBs involving the cortico subcortical areas (P<0.05).Conclusion The incidence of ICVD complicated with CMBs is associated with many factors ,and can lead to significant cognitive impairment ,which may be related with the occurrences of CMBs lesion involving the cortico subcortical areas.
