CAJ | 학술논문

目的：研究东北地区 IL-23R 基因多态性与口腔扁平苔癣的相关性。方法采用聚合酶链反应—限制性片段长度多态性（PCR-RFLP）检测66例口腔扁平苔癣患者（其中糜烂型21例）和70例健康健康对照者的 IL-23R 的两个 SNP 位点（rs10889677和 rs11465817），分析 IL-23R 基因多态性与口腔扁平苔癣的相关性。结果①rs10889677、rs11465817位点等位基因、基因型分布频率在病例组和对照组间差异无统计学意义（P ＞0．05）；② rs10889677位点基因型分布频率在糜烂型与对照组比较差异有统计学意义（P＝0．024），CC＋CA 基因型个体发生糜烂型的风险是AA 基因型的3．115倍（95％CI：1．135～8．548）。结论东北地区 OLP 人群 IL-23R 基因 rs11465817位点 SNP 与OLP 疾病易感性无明显相关性；rs10889677位点存在多态性变异，可能与 OLP 的疾病易感性和严重程度有关。
목적：연구동북지구 IL-23R 기인다태성여구강편평태선적상관성。방법채용취합매련반응—한제성편단장도다태성（PCR-RFLP）검측66례구강편평태선환자（기중미란형21례）화70례건강건강대조자적 IL-23R 적량개 SNP 위점（rs10889677화 rs11465817），분석 IL-23R 기인다태성여구강편평태선적상관성。결과①rs10889677、rs11465817위점등위기인、기인형분포빈솔재병례조화대조조간차이무통계학의의（P ＞0．05）；② rs10889677위점기인형분포빈솔재미란형여대조조비교차이유통계학의의（P＝0．024），CC＋CA 기인형개체발생미란형적풍험시AA 기인형적3．115배（95％CI：1．135～8．548）。결론동북지구 OLP 인군 IL-23R 기인 rs11465817위점 SNP 여OLP 질병역감성무명현상관성；rs10889677위점존재다태성변이，가능여 OLP 적질병역감성화엄중정도유관。
Objective To investigate single nucleotide polymorphisms(SNP)of interleukin 23R gene with oral lichen planus(OLP)in northeast china,and to provide an important genetic basis in exploring the disease susceptibility and di-verse clinical manifestation.Methods 66 patients with OLP (21 erosive OLP patients)and 70 healthy control subjects were recruited.Genomic DNA was extracted and PCR products spanning two SNPs of the IL-23R gene at positions (rs10889677 and rs11465817)were analyzed.The genotype frequencies were calculated and analyzed.Results ①The rs10889677,rs11465817 allele and genotype frequency distribution of the difference in the case group and the control group had no statistical significance (P >0.05).②The rs10889677 genotype frequency distribution in erosive compared with the control group had significant difference (P =0.024),the CC+CA genotype of the individual risk occurrence of erosion type is 3.115 times of the AA genotype (95%CI:1.135~8.548).Conclusion The Northeast OLP population of IL-23R gene rs11465817 locus SNP had no significant correlation existed in OLP disease susceptibility;polymor-phism of rs10889677 point mutation,may be associated with disease susceptibility and severity of OLP.