CAJ | 학술논문

目的：探讨血清胸苷激酶1（sTK1）在慢性阻塞性肺疾病急性加重期（AECOPD）患者中的表达及在AECOPD 治疗中的临床意义。方法：回顾性分析104例AECOPD治疗后患者的临床资料，根据治疗后情况分为治疗有效组70例及治疗无效组34例，应用免疫印迹－增强化学发光法检测治疗前后sTK1水平的差异，并将治疗后两组的sTK1与CRP的表达进行相关性分析。结果：有效组患者治疗后的sTK1与CRP的水平较治疗前明显降低，差异有统计学意义（均 P ＜0．05），无效组两者的水平较治疗前降低，但差异无统计学意义（P ＞0．05）；104例患者治疗前后sTK1与CRP的表达有相关性（均P ＜0．05）。结论：sTK1对AECOPD患者病情的评估及疗效的判断具有参考价值。
목적：탐토혈청흉감격매1（sTK1）재만성조새성폐질병급성가중기（AECOPD）환자중적표체급재AECOPD 치료중적림상의의。방법：회고성분석104례AECOPD치료후환자적림상자료，근거치료후정황분위치료유효조70례급치료무효조34례，응용면역인적－증강화학발광법검측치료전후sTK1수평적차이，병장치료후량조적sTK1여CRP적표체진행상관성분석。결과：유효조환자치료후적sTK1여CRP적수평교치료전명현강저，차이유통계학의의（균 P ＜0．05），무효조량자적수평교치료전강저，단차이무통계학의의（P ＞0．05）；104례환자치료전후sTK1여CRP적표체유상관성（균P ＜0．05）。결론：sTK1대AECOPD환자병정적평고급료효적판단구유삼고개치。
Objective To investigate the relations and evaluation value of serum thymidine kinase 1 (sTK1) in the treatment of patients withacute exacerbation of chronic obstructive pulmonarydisease (AECOPD). Methods The retrospective treating studies were performed on 104 patients with AECOPD , sTK1 level was de-tected by chemiluminescence dot-blot assay before and after treatment , and the correlation between the expression of sTK1 and CRP after treatment in the two groups was analyzed. Results The levels of sTK1 and CRP in the ef-fective group significantly lowered after treatment (P < 0.05). The expression of sTK1 in the effective group and in the ineffective group after treatment was significantlycorrelated with CRP (P < 0.05). Conclusion sTK1 can be used as a valuable indicator to evaluate the severity of AECOPD and to estimate the efficacy of AECOPD thera-py.