CAJ | 학술논문

目的：探讨头孢菌类药物不良反应患者临床分析。方法选取2013年10月～2014年11月44例我院发生头孢菌素类药物不良反应的患者作为研究对象，进行回顾性分析，分析患者不良反应的发生机制和情况。结果服用头孢类药物出现不良反应的原因排名前三的是：个体差异占38.6%，服药后24 h内饮酒占29.5%，饮食原因占13.6%；不良反应的临床表现主要有过敏不良反应、消化系统不良反应、泌尿系统不良反应等，结果有统计学意义（P<0.05）。结论头孢菌素类药物的临床用药要遵循用药剂量、禁忌证及注意事项，提高用药的安全性，降低不良反应的发生率，应该引起高度的临床重视。
목적：탐토두포균류약물불량반응환자림상분석。방법선취2013년10월～2014년11월44례아원발생두포균소류약물불량반응적환자작위연구대상，진행회고성분석，분석환자불량반응적발생궤제화정황。결과복용두포류약물출현불량반응적원인배명전삼적시：개체차이점38.6%，복약후24 h내음주점29.5%，음식원인점13.6%；불량반응적림상표현주요유과민불량반응、소화계통불량반응、비뇨계통불량반응등，결과유통계학의의（P<0.05）。결론두포균소류약물적림상용약요준순용약제량、금기증급주의사항，제고용약적안전성，강저불량반응적발생솔，응해인기고도적림상중시。
Objective Clinical analysis on patients with cephalosporins adverse reactions is to be investigated. Methods Selected 44 patients suffering from cephalosporins adverse reactions that were treated in hospital from October 2013 to November 2014 as study objects and reviewed and analyzed cephalosporins adverse reactions mechanism and its condition. Results Top three reasons for cephalosporins adverse reactions were: individualization discrepancy(38.6%),taking alcohol within 24 hours of medication treatment(29.5%),dietary reason(13.6%),and what’s more,clinical symptoms of cephalosporins adverse reactions were mainly including al ergy adverse reaction,digestive system adverse reactions and urinary system adverse reactions,such a result had statistic value(P<0.05). Conclusion Clinical cephalosporins application is required to follow its dosage, medication contraindications and precautions in order to increase medication safety and decrease adverse reaction incidence,thus,cephalosporin application is suggested to be paid attention in clinical treatment.