现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
MODERN JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2015年
16期
1741-1743
,共3页
T2DM%下肢血管病变%LPA%hs-CRP%相关性
T2DM%下肢血管病變%LPA%hs-CRP%相關性
T2DM%하지혈관병변%LPA%hs-CRP%상관성
T2DM%lower extremity venous disease%LPA,hs-CRP%correlation
目的:探讨2型糖尿病( T2DM)下肢血管病变与溶血磷脂酸( LPA)、超敏C反应蛋白( hs-CRP)的相关性。方法根据是否并发下肢血管病变,将T2DM患者87例分为单纯T2DM组38例和T2DM并发组49例,另选择同期接受体检的健康者30例为对照组。比较3组年龄、性别、体质量指数(BMI)、病程、收缩压(SBP)、舒张压(DBP)、颈动脉内膜厚度、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、胆固醇(TC)、三酰甘油(TG)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、LPA、hs-CRP差异,并进行单因素分析和Logistic回归分析。结果3组病程、颈动脉内膜厚度、SBP、LDL-C、HDL-C、TC、TG、FBG、HbA1c、LPA、hs -CRP 比较差异有统计学意义( P均<0.05)。单因素分析结果显示,病程、SBP、LDL-C、HDL-C、TG、FBG、HbA1c、LPA、hs-CRP与T2DM下肢血管病变具有相关性(P<0.05)。对单因素分析中的显著性变量进行Logistic 回归分析,结果显示,HbA1c、LPA、hs -CRP 是T2DM下肢血管病变的独立危险因素(OR=5.882,4.178,2.013;P=0.001,0.000,0.024)。结论 LPA、hs-CRP是T2DM下肢血管病变的独立危险因素,对下肢血管病变的早期诊疗具有重要意义。
目的:探討2型糖尿病( T2DM)下肢血管病變與溶血燐脂痠( LPA)、超敏C反應蛋白( hs-CRP)的相關性。方法根據是否併髮下肢血管病變,將T2DM患者87例分為單純T2DM組38例和T2DM併髮組49例,另選擇同期接受體檢的健康者30例為對照組。比較3組年齡、性彆、體質量指數(BMI)、病程、收縮壓(SBP)、舒張壓(DBP)、頸動脈內膜厚度、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、膽固醇(TC)、三酰甘油(TG)、空腹血糖(FBG)、糖化血紅蛋白(HbA1c)、LPA、hs-CRP差異,併進行單因素分析和Logistic迴歸分析。結果3組病程、頸動脈內膜厚度、SBP、LDL-C、HDL-C、TC、TG、FBG、HbA1c、LPA、hs -CRP 比較差異有統計學意義( P均<0.05)。單因素分析結果顯示,病程、SBP、LDL-C、HDL-C、TG、FBG、HbA1c、LPA、hs-CRP與T2DM下肢血管病變具有相關性(P<0.05)。對單因素分析中的顯著性變量進行Logistic 迴歸分析,結果顯示,HbA1c、LPA、hs -CRP 是T2DM下肢血管病變的獨立危險因素(OR=5.882,4.178,2.013;P=0.001,0.000,0.024)。結論 LPA、hs-CRP是T2DM下肢血管病變的獨立危險因素,對下肢血管病變的早期診療具有重要意義。
목적:탐토2형당뇨병( T2DM)하지혈관병변여용혈린지산( LPA)、초민C반응단백( hs-CRP)적상관성。방법근거시부병발하지혈관병변,장T2DM환자87례분위단순T2DM조38례화T2DM병발조49례,령선택동기접수체검적건강자30례위대조조。비교3조년령、성별、체질량지수(BMI)、병정、수축압(SBP)、서장압(DBP)、경동맥내막후도、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、담고순(TC)、삼선감유(TG)、공복혈당(FBG)、당화혈홍단백(HbA1c)、LPA、hs-CRP차이,병진행단인소분석화Logistic회귀분석。결과3조병정、경동맥내막후도、SBP、LDL-C、HDL-C、TC、TG、FBG、HbA1c、LPA、hs -CRP 비교차이유통계학의의( P균<0.05)。단인소분석결과현시,병정、SBP、LDL-C、HDL-C、TG、FBG、HbA1c、LPA、hs-CRP여T2DM하지혈관병변구유상관성(P<0.05)。대단인소분석중적현저성변량진행Logistic 회귀분석,결과현시,HbA1c、LPA、hs -CRP 시T2DM하지혈관병변적독립위험인소(OR=5.882,4.178,2.013;P=0.001,0.000,0.024)。결론 LPA、hs-CRP시T2DM하지혈관병변적독립위험인소,대하지혈관병변적조기진료구유중요의의。
Objective It is to explore the correlation of lower extremity venous disease with lysophosphatidic acid ( LPA) and hs-CRP.Methods 87 cases of patients with T2DM were divided into simple T2DM group (n=38) and T2DM with com-plication group ( n=49 ) according to whether complicating with lower extremity venous disease , 30 cases of healthy person undergoing body examination were selected as control group .The differences in age, fender, BMI, disease course, SBP, DBP, IMT, LDL-C, HDL-C, TC, TG, FBG, HbA1c LPA and hs-CRP were compared among the three groups , and sim-ple factor analysis and Logistic analysis were performed on .Results There were significant differences in disease course , SBP, IMT, LDL-C, HDL-C, TC, TG, FBG, HbA1c, LPA and hs -CRP (P all <0.05).Simple factor analysis results showed that disease course , SBP, LDL-C, HDL-C, TG, FBG, HbA1c, LPA and hs-CRP were correlated with lower ex-tremity venous disease(P<0.05).The results of Logistic analysis of significant variable in simple factor analysis showed that HbA1c, LPA, hs-CRP were the dependent Risk factors (OR=5.882, 4.178, 2.013;P=0.001, 0.000, 0.024) of lower extremity venous disease .Conclusion LPA, hs-CRP are the dependent risk factors of lower extremity venous disease , which have important significance for the early diagnosis and treatment for lower extremity venous disease .