CAJ | 학술논문

糖尿病是一种以慢性高血糖为特征的代谢性疾病，可引起多种并发症，主要表现在全身微循环的障碍，如肾、眼、心血管及神经等慢性损伤。栀子苷是栀子的主要有效成分，其水解苷元为京尼平。有研究报道，栀子苷具有降低血糖，改善糖尿病并发症病理变化的作用，有望成为糖尿病治疗的潜在药物。本文对近年来栀子苷和京尼平治疗糖尿病的相关研究进行总结，以期为深入研究其治疗糖尿病的分子机制提供思路。
당뇨병시일충이만성고혈당위특정적대사성질병，가인기다충병발증，주요표현재전신미순배적장애，여신、안、심혈관급신경등만성손상。치자감시치자적주요유효성분，기수해감원위경니평。유연구보도，치자감구유강저혈당，개선당뇨병병발증병리변화적작용，유망성위당뇨병치료적잠재약물。본문대근년래치자감화경니평치료당뇨병적상관연구진행총결，이기위심입연구기치료당뇨병적분자궤제제공사로。
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglyce-mia. Untreated, diabetes can cause many complications. It mainly reflects in systemic microcirculation dis-order, including kidney, eyes, cardiovascular system and nerves damage. Geniposide is the main effective components of traditional Chinese medicine Gardenia jasminoides Ellis,and its hydrolysed aglycon is genip-in. Pharmacological studies showed that geniposide and genipin could result in blood glucose decrease, treat diabetic complication and be expected to become the new drugs for the treatment of diabetes mellitus. This review summarizes studies of geniposide and genipin for diabetes therapy recently, in order to further re-search on the molecular mechanism for the treatment of diabetes.