南昌大学学报（医学版）
南昌大學學報（醫學版）
남창대학학보（의학판）
ACTA ACADEMIAE MEDICINAE JIANGXI
2015年
2期
80-82,102
,共4页
马春曦%邓兰%彭国林%杨尚凌%宋建文%许丽娟
馬春晞%鄧蘭%彭國林%楊尚凌%宋建文%許麗娟
마춘희%산란%팽국림%양상릉%송건문%허려연
谷氨酰胺%胸部恶性肿瘤%放射治疗%急性放射性食管炎
穀氨酰胺%胸部噁性腫瘤%放射治療%急性放射性食管炎
곡안선알%흉부악성종류%방사치료%급성방사성식관염
glutamine%thoracic malignancies%radiotherapy%acute radiation esophagitis
目的：探讨谷氨酰胺对急性放射性食管炎的临床疗效。方法将62例胸部恶性肿瘤放疗患者随机分成谷氨酰胺组（n＝31）和对照组（n＝31），2组均采用三维适形放疗。从放疗的第1天至放疗结束后2周，谷氨酰胺组在早、中、晚三餐餐后30 min 和睡觉前服用0．15 g·L－1谷氨酰胺25 mL；对照组服用生理盐水，用法用量同谷氨酰胺组。采用临床症状 RTOG 评分标准和内镜 Kuwaht’s 评分系统比较2组急性放射性食管炎的发生情况。结果临床症状RTOG 评分谷氨酰胺组2级及以上急性放射性食管炎发生率为22．58％，3级及以上急性放射性食管炎发生率为3．22％；对照组分别为61．29％、12．90％，对照组均显著高于谷氨酰胺组，差异具有统计学意义（P ＜0．05）。内镜 Kuwaht’s 评分谷氨酰胺组2级及以上急性放射性食管炎发生率为16．67％，对照组为55．56％，对照组显著高于谷氨酰胺组，差异具有统计学意义（P ＜0．05）。结论谷氨酰胺可减轻放疗对食管的毒性。
目的：探討穀氨酰胺對急性放射性食管炎的臨床療效。方法將62例胸部噁性腫瘤放療患者隨機分成穀氨酰胺組（n＝31）和對照組（n＝31），2組均採用三維適形放療。從放療的第1天至放療結束後2週，穀氨酰胺組在早、中、晚三餐餐後30 min 和睡覺前服用0．15 g·L－1穀氨酰胺25 mL；對照組服用生理鹽水，用法用量同穀氨酰胺組。採用臨床癥狀 RTOG 評分標準和內鏡 Kuwaht’s 評分繫統比較2組急性放射性食管炎的髮生情況。結果臨床癥狀RTOG 評分穀氨酰胺組2級及以上急性放射性食管炎髮生率為22．58％，3級及以上急性放射性食管炎髮生率為3．22％；對照組分彆為61．29％、12．90％，對照組均顯著高于穀氨酰胺組，差異具有統計學意義（P ＜0．05）。內鏡 Kuwaht’s 評分穀氨酰胺組2級及以上急性放射性食管炎髮生率為16．67％，對照組為55．56％，對照組顯著高于穀氨酰胺組，差異具有統計學意義（P ＜0．05）。結論穀氨酰胺可減輕放療對食管的毒性。
목적：탐토곡안선알대급성방사성식관염적림상료효。방법장62례흉부악성종류방료환자수궤분성곡안선알조（n＝31）화대조조（n＝31），2조균채용삼유괄형방료。종방료적제1천지방료결속후2주，곡안선알조재조、중、만삼찬찬후30 min 화수각전복용0．15 g·L－1곡안선알25 mL；대조조복용생리염수，용법용량동곡안선알조。채용림상증상 RTOG 평분표준화내경 Kuwaht’s 평분계통비교2조급성방사성식관염적발생정황。결과림상증상RTOG 평분곡안선알조2급급이상급성방사성식관염발생솔위22．58％，3급급이상급성방사성식관염발생솔위3．22％；대조조분별위61．29％、12．90％，대조조균현저고우곡안선알조，차이구유통계학의의（P ＜0．05）。내경 Kuwaht’s 평분곡안선알조2급급이상급성방사성식관염발생솔위16．67％，대조조위55．56％，대조조현저고우곡안선알조，차이구유통계학의의（P ＜0．05）。결론곡안선알가감경방료대식관적독성。
Objective To investigate the clinical effect of glutamine on acute radiation esoph-agitis.Methods Sixty-two patients undergoing radiotherapy for thoracic malignancies were ran-domized into two groups,with 31 patients in each group.All patients received three-dimensional conformal radiotherapy.From the first day of radiotherapy to two weeks after the end of radio-therapy,the glutamine group was given 25 mL glutamine (0.15 g·L-1 )30 minutes after meals and at bedtime,respectively.The control group received an equal amount of normal saline.The oc-currence of acute radiation esophagitis was evaluated using RTOG scoring system and Kuwaht’s criteria.Results According to RTOG scoring system,the grade 2 or worse acute esophagitis was observed in 22.58% of patients in glutamine group and 61.29% of patients in control group,and the grade 3 or worse acute esophagitis was observed in 3.22% of patients in glutamine group and 12.90% of patients in control group.According Kuwaht’s criteria,the grade 2 or worse acute esophagitis was observed in 16.67% of patients in glutamine group and 55.56% of patients in control group.The incidence of grade 2 or worse acute esophagitis in glutamine group was signifi-cantly lower than that in control group (P <0.05).Conclusion Glutamine can reduce the esopha-geal toxicity induced by radiotherapy.
