中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2015年
5期
350-353
,共4页
脂肪肝,非酒精性%成纤维细胞生长因子%前瞻性研究
脂肪肝,非酒精性%成纖維細胞生長因子%前瞻性研究
지방간,비주정성%성섬유세포생장인자%전첨성연구
Fatty liver,non-alchoholic%Fibroblast growth factor%Prospective study
目的 探讨成纤维细胞生长因子(FGF-21)与非酒精性脂肪肝病(NAFLD)发生和发展的关系. 方法 通过对352例参与者进行5年的随访,记录参与者一般临床资料,采用酶联免疫吸附法(ELISA)测定基线及随访5年后血清FGF-21浓度水平,对比分析NAFLD组与非NAFLD组间FGF-21浓度水平差异.组间比较根据方差齐性采用x2检验或非参数检验,NAFLD的独立危险因素采用多因素logistic回归分析. 结果 NAFLD组基线血清FGF-21浓度水平明显高于非NAFLD组,差异有统计学意义[318.34 (169.64,520.77) pg/ml对比197.22 (121.57,318.76)pg/ml,P＜0.05];随访5年后,NAFLD组血清FGF-21浓度水平明显高于基线血清FGF-21浓度水平,差异有统计学意义[399.4 (253.9,754.2) pg/ml对比318.34 (169.64,520.77) pg/ml,P＜0.05];非NAFLD组血清FGF-21浓度水平与基线血清FGF-21浓度水平差异无统计学意义(P＞0.05).多因素logistic回归分析显示人体质量指数、总胆固醇、胰岛素抵抗指数、FGF-21是影响NAFLD发生的独立危险因素. 结论 血清FGF-21浓度水平高是NAFLD发生的独立危险因素,未来有可能成为干预NAFLD有效的分子靶点.
目的 探討成纖維細胞生長因子(FGF-21)與非酒精性脂肪肝病(NAFLD)髮生和髮展的關繫. 方法 通過對352例參與者進行5年的隨訪,記錄參與者一般臨床資料,採用酶聯免疫吸附法(ELISA)測定基線及隨訪5年後血清FGF-21濃度水平,對比分析NAFLD組與非NAFLD組間FGF-21濃度水平差異.組間比較根據方差齊性採用x2檢驗或非參數檢驗,NAFLD的獨立危險因素採用多因素logistic迴歸分析. 結果 NAFLD組基線血清FGF-21濃度水平明顯高于非NAFLD組,差異有統計學意義[318.34 (169.64,520.77) pg/ml對比197.22 (121.57,318.76)pg/ml,P＜0.05];隨訪5年後,NAFLD組血清FGF-21濃度水平明顯高于基線血清FGF-21濃度水平,差異有統計學意義[399.4 (253.9,754.2) pg/ml對比318.34 (169.64,520.77) pg/ml,P＜0.05];非NAFLD組血清FGF-21濃度水平與基線血清FGF-21濃度水平差異無統計學意義(P＞0.05).多因素logistic迴歸分析顯示人體質量指數、總膽固醇、胰島素牴抗指數、FGF-21是影響NAFLD髮生的獨立危險因素. 結論 血清FGF-21濃度水平高是NAFLD髮生的獨立危險因素,未來有可能成為榦預NAFLD有效的分子靶點.
목적 탐토성섬유세포생장인자(FGF-21)여비주정성지방간병(NAFLD)발생화발전적관계. 방법 통과대352례삼여자진행5년적수방,기록삼여자일반림상자료,채용매련면역흡부법(ELISA)측정기선급수방5년후혈청FGF-21농도수평,대비분석NAFLD조여비NAFLD조간FGF-21농도수평차이.조간비교근거방차제성채용x2검험혹비삼수검험,NAFLD적독립위험인소채용다인소logistic회귀분석. 결과 NAFLD조기선혈청FGF-21농도수평명현고우비NAFLD조,차이유통계학의의[318.34 (169.64,520.77) pg/ml대비197.22 (121.57,318.76)pg/ml,P＜0.05];수방5년후,NAFLD조혈청FGF-21농도수평명현고우기선혈청FGF-21농도수평,차이유통계학의의[399.4 (253.9,754.2) pg/ml대비318.34 (169.64,520.77) pg/ml,P＜0.05];비NAFLD조혈청FGF-21농도수평여기선혈청FGF-21농도수평차이무통계학의의(P＞0.05).다인소logistic회귀분석현시인체질량지수、총담고순、이도소저항지수、FGF-21시영향NAFLD발생적독립위험인소. 결론 혈청FGF-21농도수평고시NAFLD발생적독립위험인소,미래유가능성위간예NAFLD유효적분자파점.
Objective To investigate the prospective association of fibroblast growth factor 21 (FGF-21) with NAFLD development in a 5-year prospective study involving a population-based cohort comprising 352 Chinese subjects.Methods The clinical data of subjects were recorded,serum FGF-21 levels at baseline and follow-up were measured using an enzyme-linked immunosorbent assay,whether FGF-21 was independent predictor of NAFLD development were identified using logistic regressions.Chi-square test,non-parametric test and logistic regression analysis were used in statistical analyses.Results (1) Serum FGF-21 levels of NAFLD group was significantly higher than that of non-NAFLD group (318.34(169.64,520.77)pg/ml vs 197.22(121.57,318.76) pg/ml,P＜0.05).(2)At follow-up,significant increase of FGF-21 level was observed in those subjects who developed NAFLD (399.4(253.9,754.2) pg/ml vs 318.34(169.64,520.77)pg/ml,P＜ 0.05),but in non-NAFLD group,there was no significant difference of FGF-21 level between baseline and follow-up.(3) BMI,TC,HOMA-IR and FGF-21 were independent predictors of NAFLD through logistic regressions.Conclusion High FGF-21 levels was independent predictor of NAFLD,it may be useful for early diagnosis and intervention of NAFLD.
