国际移植与血液净化杂志
國際移植與血液淨化雜誌
국제이식여혈액정화잡지
INTERNATIONAL JOURNAL OF TRANSPLANTATION AND HEMOPURIFICATION
2015年
2期
22-25
,共4页
肾小球滤过率%慢性肾脏病%99mTc-DTPA肾动态显像法%肾小球滤过率评估公式
腎小毬濾過率%慢性腎髒病%99mTc-DTPA腎動態顯像法%腎小毬濾過率評估公式
신소구려과솔%만성신장병%99mTc-DTPA신동태현상법%신소구려과솔평고공식
Glomerular filtration rate%Chronic kidney disease%99mTc-DTPA dynamic renal imaging%Estimates glomerular filtration rate
目的 比较四种肾小球滤过率评估公式在慢性肾脏病患者中的应用价值.方法 对952例患者,以99mTc-DTPA动态显像法测定的肾小球滤过率(mGFR)为标准,测定血清肌酐和胱抑素C,用Cockcroft-Gault、简化MDRD、Levey 1、CKD-EPI公式计算出eGFR,与mGFR进行比较.结果 CG、简化MDRD、Levey 1、CKD-EPI与mGFR的相关系数分别为0.924、0.922、0.900、0.917;差值的均值分别为1.7、3.6、4.6、8.2.CG估计值在CKD1期和2期时与mGFR差异无统计学意义(P=0.144),CKD-EPI估计值在CKD1期时与mGFR差异无统计学意义(P=0.102).而从CKD3期到CKD4期,四种方法估计值与mGFR差异均有统计学意义(P=0.144).结论 CG公式在中国CKD患者中的适用性高于简化MDRD公式、CKD-EPI公式和Levey1公式.
目的 比較四種腎小毬濾過率評估公式在慢性腎髒病患者中的應用價值.方法 對952例患者,以99mTc-DTPA動態顯像法測定的腎小毬濾過率(mGFR)為標準,測定血清肌酐和胱抑素C,用Cockcroft-Gault、簡化MDRD、Levey 1、CKD-EPI公式計算齣eGFR,與mGFR進行比較.結果 CG、簡化MDRD、Levey 1、CKD-EPI與mGFR的相關繫數分彆為0.924、0.922、0.900、0.917;差值的均值分彆為1.7、3.6、4.6、8.2.CG估計值在CKD1期和2期時與mGFR差異無統計學意義(P=0.144),CKD-EPI估計值在CKD1期時與mGFR差異無統計學意義(P=0.102).而從CKD3期到CKD4期,四種方法估計值與mGFR差異均有統計學意義(P=0.144).結論 CG公式在中國CKD患者中的適用性高于簡化MDRD公式、CKD-EPI公式和Levey1公式.
목적 비교사충신소구려과솔평고공식재만성신장병환자중적응용개치.방법 대952례환자,이99mTc-DTPA동태현상법측정적신소구려과솔(mGFR)위표준,측정혈청기항화광억소C,용Cockcroft-Gault、간화MDRD、Levey 1、CKD-EPI공식계산출eGFR,여mGFR진행비교.결과 CG、간화MDRD、Levey 1、CKD-EPI여mGFR적상관계수분별위0.924、0.922、0.900、0.917;차치적균치분별위1.7、3.6、4.6、8.2.CG고계치재CKD1기화2기시여mGFR차이무통계학의의(P=0.144),CKD-EPI고계치재CKD1기시여mGFR차이무통계학의의(P=0.102).이종CKD3기도CKD4기,사충방법고계치여mGFR차이균유통계학의의(P=0.144).결론 CG공식재중국CKD환자중적괄용성고우간화MDRD공식、CKD-EPI공식화Levey1공식.
Objective To assess the diagnostic value of 4 equations using different variables for determining glomerular filtration rate in patients with CKD.Methods Retrospective observational study was performed on 952 patients.Uptake of 99mTc-DTPA application for determination of glomerular filtration rate (mGFR).Serum creatinine and cystatin C level were measured in all patients.Used the Cockcroft-Gault,abbreviation MDRD,Levey 1 and CKD-EPI equations to estimate the GFR (eGFR).The correlation between eGFR and mGFR were analysed respectively.Results The correlation coefficient of CG,abbreviation MDRD,Levey 1 and CKD-EPI were 0.924,0.922,0.900 and 0.917,respectively.The mean differences were 1.7,3.6,4.6 and 8.2,respectively.Compared with mGFR the eGFR derived from CG showed no significant difference in patients with CKD stages 1and 2 (P =0.144);the eGFR derived from CKD-EPI showed no significant difference in patients with CKD stages 1 (P =0.102).But significant difference was found between eGFR which derived from 4 equations and mGFR in patients with CKD stages 3 and 4.Conciusion CG equation is more accurate than others in Chinese CKD patients.
