国际移植与血液净化杂志
國際移植與血液淨化雜誌
국제이식여혈액정화잡지
INTERNATIONAL JOURNAL OF TRANSPLANTATION AND HEMOPURIFICATION
2015年
2期
33-35
,共3页
炎症因子%他汀类药物%降脂治疗
炎癥因子%他汀類藥物%降脂治療
염증인자%타정류약물%강지치료
Inflammatory cytokines%Statins%Lipid-lowering therapy
目的 比较他汀类药物在单纯高脂血症和慢性炎症性疾病伴高脂血症患者中的调脂治疗疗效,探讨炎症与脂代谢紊乱之间的关联.方法 选择于我院住院或门诊血脂指标异常患者53例,根据患者是否具有慢性炎症性原发疾病将其分为对照组(单纯高脂血症组,n=34)、结缔组织病组(n=9)、原发性慢性肾脏疾病组(CKD组,n=10).各组患者均采用普伐他汀钠(20 mg/d)口服治疗8周.于用药前和用药后2、4、8周分别空腹留取静脉血10 ml检测TC、TG、HDL、LDL、IL-6、hs-CRP、BUN、SCr、TB、Alb、ALT及AST.结果 各组患者用药前的血脂指标(TC、LDL、HDL、TG)间无显著差异.结缔组织病组和CKD组患者血清炎症因子(IL-6、hs-CRP)的水平显著高于对照组(P＜0.05).对照组用药后各时间点TC和LDL与用药前比较均有显著下降(P＜0.05).在CKD和结缔组织病组中,患者的炎症因子(IL-6、hs-CRP)水平显著升高,普伐他汀钠治疗后患者TC和LDL均无显著下降(P＞0.05).结论 具有慢性炎症性疾病伴高脂血症的患者体内炎症因子处于高水平状态.炎症因子对他汀类药物的降脂作用可能有抑制作用.
目的 比較他汀類藥物在單純高脂血癥和慢性炎癥性疾病伴高脂血癥患者中的調脂治療療效,探討炎癥與脂代謝紊亂之間的關聯.方法 選擇于我院住院或門診血脂指標異常患者53例,根據患者是否具有慢性炎癥性原髮疾病將其分為對照組(單純高脂血癥組,n=34)、結締組織病組(n=9)、原髮性慢性腎髒疾病組(CKD組,n=10).各組患者均採用普伐他汀鈉(20 mg/d)口服治療8週.于用藥前和用藥後2、4、8週分彆空腹留取靜脈血10 ml檢測TC、TG、HDL、LDL、IL-6、hs-CRP、BUN、SCr、TB、Alb、ALT及AST.結果 各組患者用藥前的血脂指標(TC、LDL、HDL、TG)間無顯著差異.結締組織病組和CKD組患者血清炎癥因子(IL-6、hs-CRP)的水平顯著高于對照組(P＜0.05).對照組用藥後各時間點TC和LDL與用藥前比較均有顯著下降(P＜0.05).在CKD和結締組織病組中,患者的炎癥因子(IL-6、hs-CRP)水平顯著升高,普伐他汀鈉治療後患者TC和LDL均無顯著下降(P＞0.05).結論 具有慢性炎癥性疾病伴高脂血癥的患者體內炎癥因子處于高水平狀態.炎癥因子對他汀類藥物的降脂作用可能有抑製作用.
목적 비교타정류약물재단순고지혈증화만성염증성질병반고지혈증환자중적조지치료료효,탐토염증여지대사문란지간적관련.방법 선택우아원주원혹문진혈지지표이상환자53례,근거환자시부구유만성염증성원발질병장기분위대조조(단순고지혈증조,n=34)、결체조직병조(n=9)、원발성만성신장질병조(CKD조,n=10).각조환자균채용보벌타정납(20 mg/d)구복치료8주.우용약전화용약후2、4、8주분별공복류취정맥혈10 ml검측TC、TG、HDL、LDL、IL-6、hs-CRP、BUN、SCr、TB、Alb、ALT급AST.결과 각조환자용약전적혈지지표(TC、LDL、HDL、TG)간무현저차이.결체조직병조화CKD조환자혈청염증인자(IL-6、hs-CRP)적수평현저고우대조조(P＜0.05).대조조용약후각시간점TC화LDL여용약전비교균유현저하강(P＜0.05).재CKD화결체조직병조중,환자적염증인자(IL-6、hs-CRP)수평현저승고,보벌타정납치료후환자TC화LDL균무현저하강(P＞0.05).결론 구유만성염증성질병반고지혈증적환자체내염증인자처우고수평상태.염증인자대타정류약물적강지작용가능유억제작용.
Objective To explore the relationship between inflammation and lipid metabolism by comparing the effections of statins in simple hyperlipidemia and chronic inflammatory disease with hyperlipidemia in patients.So we can offer some clinical basis for appropriate lipid lowering therapy.Methods A total of 53 cases of patients with abnormal serum lipids were divided into three groups according to whether patients with chronic inflammatory primary diseases:control group (pure hypercholesterolemia Group),connective tissue disease group and CKD group.Pravastatin sodium(20 mg/d)were given to each patients.TC,TG,HDL,LDL,IL-6,hs-CRP 、BUN、Cr、TB、Alb、ALT、AST were detected after 2,4,8weeks,respectively.Results Lipid parameters (TC,LDL,HDL,TG) had no significant difference between the three group before treatment.The level of IL-6,hs-CRP were significantly increased in connective tissue disease group and CKD group as compared to the normal control group(P ＜ 0.05).Level of TC,LDL decreased significantly in control group after treatment,and the lower rate was greater than the other two groups (P ＜ 0.05).TC and LDL level in connective tissue disease and CKD group had no significant decline after treatment with the highest levels of inflammatory factors.Conslusion Patients with chronic inflammatory hyperlipidemia disease has a high level of inflammatory cytokines,and they might inhibit the role of lipid-lowering statin drugs.
