CAJ | 학술논문

目的：对阿奇霉素联合红霉素治疗小儿支原体肺炎（ Mycoplasmal Pneumonia，MP）的疗效进行研究。方法选择本院于2010年7月至2012年7月期间收治的MP患儿63例。将患儿随机分为观察组和对照组。观察组采用阿奇霉素和红霉素联合医治；对照组仅采用阿奇霉素医治。观察组有37例；对照组有26例。观察两组患儿的治疗效果；退热、止咳及住院天数；不良反应发生情况。结果观察组总有效率为97．3％；而对照组总有效率为76．9％，两组疗效相比，差异具有统计学意义（P＜0．05）；治疗后，观察组的平均退热天数（2．1±0．9） d远低于对照组的（3．7±2．2） d，P＜0．05；观察组的平均止咳天数（4．6±1．4）d远低于另一组的（7．2±3．1）d，P＜0．05；且前者的平均住院天数（6．0±1．5）d也远低于后者的（8．2±4．0）d，P＜0．05。两组的不良反应发生情况无显著差异（P＞0．05）。结论阿奇霉素联合红霉素的方法医治效果优于单用阿奇霉素的疗法，是安全可靠的治疗方式。
목적：대아기매소연합홍매소치료소인지원체폐염（ Mycoplasmal Pneumonia，MP）적료효진행연구。방법선택본원우2010년7월지2012년7월기간수치적MP환인63례。장환인수궤분위관찰조화대조조。관찰조채용아기매소화홍매소연합의치；대조조부채용아기매소의치。관찰조유37례；대조조유26례。관찰량조환인적치료효과；퇴열、지해급주원천수；불량반응발생정황。결과관찰조총유효솔위97．3％；이대조조총유효솔위76．9％，량조료효상비，차이구유통계학의의（P＜0．05）；치료후，관찰조적평균퇴열천수（2．1±0．9） d원저우대조조적（3．7±2．2） d，P＜0．05；관찰조적평균지해천수（4．6±1．4）d원저우령일조적（7．2±3．1）d，P＜0．05；차전자적평균주원천수（6．0±1．5）d야원저우후자적（8．2±4．0）d，P＜0．05。량조적불량반응발생정황무현저차이（P＞0．05）。결론아기매소연합홍매소적방법의치효과우우단용아기매소적요법，시안전가고적치료방식。
Objective To observe the clinical efficacy of azithromycin combined with erythromycin in treatment of the mycoplasma pneumonia( MP) in children.Methods 63 children with MP in our hospital from July 2010 to July 2012 were selected.All the children were randomly divided into two groups:observation group and control group.The observation group were treated with azithromycin and erythromycin;the control group only treated with azithromycin.There were 37 cases in observation group and 26 cases in control group.The treatment efficacy was observed and recorded, as well as time of fever, cough and hospital stay;the occurrence of adverse reactions.Results The total effective rate was 97.3% in observation group; and the total effective rate was 76.9%in control group.Efficacy of the observation group is better than the control group (P <0.05). Moreover, after drug treatment, the average time of fever in observation group was (2.1 ±0.9) d, which was much lower than the control group of (3.7 ±2.2) d, P<0.05.The average time of cough in observation group was (4.6 ±1.4)d ,which was much lower than the other group of (7.2 ±3.1) d, P <0.05.And the average time of staying in hospital in observation group was (6.0 ±1.5)d, which was also much lower than the (8.2 ± 4.0)d in control group, P<0.05.The incidence of adverse effects between two groups was not significantly different (P >0.05).Conclusions The clinical efficacy of azithromycin combined with erythromycin in treatment of the mycoplasma pneumonia in children is better than azithromycin therapy alone, the combined therapy is reliable and safety.