CAJ | 학술논문

目的探讨胰腺癌组织中骨形成蛋白和激活素的跨膜抑制剂(BAMBI)的表达及其临床意义.方法应用免疫组化方法检测69例胰腺癌组织和36例癌旁正常胰腺组织中BAMBI的表达,分析其与胰腺癌临床病理参数和患者生存率的关系.结果胰腺癌组织中BAMBI的阳性表达率明显高于正常胰腺组织(56.5％比16.7％,P＜0.01).胰腺癌组织BAMBI的表达与患者年龄、性别及肿瘤大小、分化程度无相关性,但淋巴结转移组BAMBI阳性表达率高于无淋巴结转移组(67.4％比38.5,P=0.019),TNM分期Ⅲ期组BAMBI阳性表达率高于Ⅰ+Ⅱ期组(75.0比31.0％,P=0.001).胰腺癌组织BAMBI阳性患者的中位生存时间为6个月,显著低于BAMBI阴性组的10个月(P=0.035).结论胰腺癌组织高表达BAMBI,BAMBI的高表达与肿瘤淋巴结转移、TNM分期、分化程度及患者预后有关.
목적 탐토이선암조직중골형성단백화격활소적과막억제제(BAMBI)적표체급기림상의의.방법 응용면역조화방법검측69례이선암조직화36례암방정상이선조직중BAMBI적표체,분석기여이선암림상병리삼수화환자생존솔적관계.결과 이선암조직중BAMBI적양성표체솔명현고우정상이선조직(56.5％비16.7％,P＜0.01).이선암조직BAMBI적표체여환자년령、성별급종류대소、분화정도무상관성,단림파결전이조BAMBI양성표체솔고우무림파결전이조(67.4％비38.5,P=0.019),TNM분기Ⅲ기조BAMBI양성표체솔고우Ⅰ+Ⅱ기조(75.0비31.0％,P=0.001).이선암조직BAMBI양성환자적중위생존시간위6개월,현저저우BAMBI음성조적10개월(P=0.035).결론 이선암조직고표체BAMBI,BAMBI적고표체여종류림파결전이、TNM분기、분화정도급환자예후유관.
Objective To investigate the expression of BAMBI in pancreatic carcinoma tissue and its clinical value.Methods Expression of BAMBI was detected by immunohistochemistry in 69 cases of pancreatic cancer and 15 normal pancreatic samples.The survival and its association with clinicopathologic parameters were analyzed.Results The expression of BAMBI in the cancer tissue was much higher than that in the normal tissues (56.5％ vs 16.7％,P ＜0.01).The expression of BAMBI was not associated with age,sex and tumor size,differentiation,but expression of BAMBI in patient with lymph node metastasis was higher than that in patient without lymph node metastasis (67.4％ vs 38.5％,P =0.019),the expression of BAMBI in TNM stage Ⅲ was higher than that in stage Ⅰ + Ⅱ (75.0％ vs 31.0％,P =0.001).The median survival of BAMBI-positive group (6 months) was lower than that of BAMBI-negative group (10 months).Conclusions BAMBI is over-expressed in pancreatic carcinoma,and its expression is associated with lymph node metastasis,TNM staging,differentiation and prognosis.