CAJ | 학술논문

目的检测慢性胰腺炎(CP)患者各项血液自身免疫指标的阳性率,探讨其临床价值.方法检测上海长海医院消化科就诊的409例CP患者的抗可提取性核抗原抗体(抗ENA抗体)、抗胞浆型中性粒细胞抗体、抗β2-糖蛋白1抗体(anti-β2-GPI)、抗心磷脂抗体(ACA)、抗单链-DNA抗体等25项血清相关自身免疫指标,并与系统检索的Pubmed数据库内相关文献的健康人群阳性率进行比较.结果 409例CP患者中仅检出anti-β2-GPI、ACA、抗双链-DNA抗体阳性患者,阳性率分别为11.7％、1.4％、1.9％,其余指标均为阴性.其中anti-β2-GPI阳性率与健康人群相比有显著提高(11.7％比3.4％),ACA阳性率低于健康人群(1.4％比4.1％),差异均有统计学意义(P值均＜0.05).而抗单链-DNA抗体阳性率与健康人群的差异无统计学意义.结论 anti-β2-GPI对于CP的诊疗具有潜在价值,ACA的临床意义尚不确定.
목적 검측만성이선염(CP)환자각항혈액자신면역지표적양성솔,탐토기림상개치.방법 검측상해장해의원소화과취진적409례CP환자적항가제취성핵항원항체(항ENA항체)、항포장형중성립세포항체、항β2-당단백1항체(anti-β2-GPI)、항심린지항체(ACA)、항단련-DNA항체등25항혈청상관자신면역지표,병여계통검색적Pubmed수거고내상관문헌적건강인군양성솔진행비교.결과 409례CP환자중부검출anti-β2-GPI、ACA、항쌍련-DNA항체양성환자,양성솔분별위11.7％、1.4％、1.9％,기여지표균위음성.기중anti-β2-GPI양성솔여건강인군상비유현저제고(11.7％비3.4％),ACA양성솔저우건강인군(1.4％비4.1％),차이균유통계학의의(P치균＜0.05).이항단련-DNA항체양성솔여건강인군적차이무통계학의의.결론 anti-β2-GPI대우CP적진료구유잠재개치,ACA적림상의의상불학정.
Objective To explore the positive rate of each autoimmunity parameters in patients with chronic pancreatitis.Methods Four hundred and nine chronic pancreatitis patients treated in Department of Gastroenterology of Changhai Hospital were selected and the 25 autoimmunity parameters included anti-ENA antibody,anti-neutrophil cytoplasmic antibody,anti-β2-GPI,anticardiolipin antibody (ACA),anti dsDNA antibody were determined,then a literature search was performed to compare the autoimmune positive rate of healthy people in Pubmed database with chronic pancreatitis patients.Results Among 409 patients,the positive rates of anti β2-GPI,ACA,and anti dsDNA antibody were 11.7％,1.4％,and 1.9％,respectively,whereas other indicators were negatively expressed.The positive rate of anti β2-GPI in CP patients was significantly higher than that of healthy group (11.7％ vs 3.4％),and the positive rate of ACA was lower than that of healthy group (1.4％ vs 4.1％),and the difference between the two groups was statistically significant (P ＜ 0.05).Conclusions Anti β2-GPI shows some potential value in the diagnosis and treatment of chronic pancreatitis,but the clinical significance of ACA is uncertain.