CAJ | 학술논문

以介孔二氧化硅、超分子β-环糊精修饰玻碳电极制备新型柔红霉素电化学传感器。采用X-射线衍射、原子力显微镜及场发射扫描电镜对修饰材料及修饰电极进行表征；以循环伏安法和电化学交流阻抗等方法研究修饰电极的电化学特性。由于介孔二氧化硅较大的比表面积和β-环糊精对柔红霉素的特异性结合，该修饰电极对于柔红霉素有较好的电流响应。在优化实验条件下，该传感器对柔红霉素的响应范围分为两部分：1.0×10-6~5.0×10-5 mol/L，线性相关系数r=0.9950；5.0×10-5~2.5×10-4 mol/L，线性相关系数r=0.9990。检测限为2.0×10-7 mol/L (信噪比S/N=3)。
이개공이양화규、초분자β-배호정수식파탄전겁제비신형유홍매소전화학전감기。채용X-사선연사、원자력현미경급장발사소묘전경대수식재료급수식전겁진행표정；이순배복안법화전화학교류조항등방법연구수식전겁적전화학특성。유우개공이양화규교대적비표면적화β-배호정대유홍매소적특이성결합，해수식전겁대우유홍매소유교호적전류향응。재우화실험조건하，해전감기대유홍매소적향응범위분위량부분：1.0×10-6~5.0×10-5 mol/L，선성상관계수r=0.9950；5.0×10-5~2.5×10-4 mol/L，선성상관계수r=0.9990。검측한위2.0×10-7 mol/L (신조비S/N=3)。
A novel electrochemical sensor for DNR detection based on mesoporous silica/β-cyclodextrin modified GCE was developed. The nanostructure of the synthesized mesoporous silica were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and Atomic Force Microscope (AFM). Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) experiments were carried out to investigate the electrochemical properties of the modified electrode. The sensor exhibited good amperometric response towards daunorubicin (DNR) due to the large specific area and specific binding among the DNR, mesoporous silica andβ-cyclodextrin. Under optimum conditions, the current response of the sensor increased linearly with the concentration of DNR from 1.0×10-6~5.0×10-5 mol/L(with a relative coefficient r=0.9950)and 5.0 × 10-5~2.5 × 10-4 mol/L(with a relative coefficient r=0.9990). The detection limit was 2.0×10-7 mol/L (S/N=3). The results indicated that the modified electrode showed a good performance in reproducibility, stability.