CAJ | 학술논문

目的：研究中医辩证结合氯沙坦方案治疗糖尿病肾病的疗效及对肾功能和血脂代谢的影响。方法两组患者均采用常规降血糖治疗，同时辅助饮食与运动治疗，维持患者血压稳定。对照组患者采用氯沙坦[1次/(片·d)]治疗，观察组在对照组的基础上采用中医辩证方案辅助治疗，同时观察两组患者的尿蛋白排泄率(UAER)、血肌醉(Cr)和血尿素氮(BuN)的临床变化，以及对两组患者的肾功能和血脂代谢水平。结果两组患者临床有效率对比，观察组患者有效率为91.11%(41/45)，对照组患者有效率为64.44%(29/45)，两组患者对比差异有统计学意义(P<0.05)。两组患者的UAER、Cr和BuN均出现了明显的下降，且观察组明显优于对照组(P<0.05)。两组患者血脂代谢指标均有所改善，且观察组高密度脂蛋白提高与低密度脂蛋白降低优于对照组，差异有统计学意义(P<0.05)。结论中医辩证结合氯沙坦方案治疗糖尿病肾病临床效果显著，患者的UAER、Cr、BUN能够得到有效地改善，且对患者肾功能和血脂代谢具有正面影响作用，充分说明了中医辩证结合氯沙坦方案的临床效果，值得临床广为推广应用。
목적：연구중의변증결합록사탄방안치료당뇨병신병적료효급대신공능화혈지대사적영향。방법량조환자균채용상규강혈당치료，동시보조음식여운동치료，유지환자혈압은정。대조조환자채용록사탄[1차/(편·d)]치료，관찰조재대조조적기출상채용중의변증방안보조치료，동시관찰량조환자적뇨단백배설솔(UAER)、혈기취(Cr)화혈뇨소담(BuN)적림상변화，이급대량조환자적신공능화혈지대사수평。결과량조환자림상유효솔대비，관찰조환자유효솔위91.11%(41/45)，대조조환자유효솔위64.44%(29/45)，량조환자대비차이유통계학의의(P<0.05)。량조환자적UAER、Cr화BuN균출현료명현적하강，차관찰조명현우우대조조(P<0.05)。량조환자혈지대사지표균유소개선，차관찰조고밀도지단백제고여저밀도지단백강저우우대조조，차이유통계학의의(P<0.05)。결론중의변증결합록사탄방안치료당뇨병신병림상효과현저，환자적UAER、Cr、BUN능구득도유효지개선，차대환자신공능화혈지대사구유정면영향작용，충분설명료중의변증결합록사탄방안적림상효과，치득림상엄위추엄응용。
Objective?To?study?the?effect?of?TCM?syndrome?differentiation?combined?with?Losartan?on?diabetic?nephropathy?and?renal?function?and?blood?lipid?metabolism.?Methods?Both?the?control?group?and?observation?group?were?treated?by?the?conventional?hypoglycemic?treatment,?supplemented?by?diet?and?exercise?treatment?as?well?as?maintained?blood?pressure?stablely.?In?addition,?the?control?group?took?Losartan?one?tablet?once?a?day,?and?the?observation?group?adopted?TCM?syndrome?differentiation?treatment?based?on?the?treatment?given?to?the?control?group.?And?the?clinical?changes?in?urinary?albumin?excretion?rate(UAER),?serum?creatinine(Cr),?blood?urea?nitrogen(BuN),?and?renal?function?as?well?as?the?level?of?blood?lipid?metabolism?were?observed?in?both?groups.?Results?The?response?rate?was?91.11%(41/45)?in?the?observation?group,?and?that?was?64.44%(29/45)?in?the?control?group,?the?difference?in?the?clinical?response?rate?between?the?two?groups?was?statistically?significant?(P<0.05).?The?UAER,?Cr?and?BuN?in?both?groups?showed?significant?reductions,?but?the?reductions?in?the?observation?group?were?greater?than?those?in?the?control?group(P<0.05).?Lipid?metabolism?index?in?both?groups?improved,?but?compared?with?the?control?group,?the?observation?group?had?higher?extent?of?high?density?lipoprotein?increase?and?low?density?lipoprotein?reduction?with?statistical?significance(P<0.05).?Conclusion?For?patients?with?diabetic?nephropathy,?TCM?syndrome?differentiation?combined?with?Losartan?has?significant?clinical?effect,?which?can?effectively?improve?the?UAER,?Cr?and?BUN,?positively?affect?the?renal?function?and?blood?lipid?metabolism,?therefore?it?is?worthy?of?clinical?application?and?promotion.