目的 系统评价添加ω-3多不饱和脂肪酸的营养支持对消化系统恶性肿瘤患者免疫功能与营养状况的影响.方法 检索MEDLINE、EMBASE、Cochrane对照试验中心注册数据库(CENTRAL)、中国知网(CNKI)和中国生物医学文献数据库(CBM),检索起止时间为数据库默认时间.检索主题词选择omega-3 fatty acids、fish oil、cancer、tumor、neoplasms、ω-3多不饱和脂肪酸、鱼油、恶性肿瘤和癌症.采用Jadad量表进行研究质量评价,筛选出高质量随机对照试验.采用RevMan 5.2统计软件进行分析,研究ω-3多不饱和脂肪酸对消化系统恶性肿瘤患者免疫和营养指标的影响.结果 共纳入12项高质量随机对照试验.Meta分析结果显示,ω-3多不饱和脂肪酸支持组的CD4+%(I2=0%,95% CI=3.44~6.93,Z=5.82,P<0.00001)、CD8+%(I2=0%,95%CI=2.44~7.13,Z=4.00,P<0.000 1)、CD4+%/CD8+%(I2=74%,95% CI=0.16~0.83,Z=2.87,P=0.004)、IgA(I2=14%,95% CI=0.21~0.43,Z=5.84,P<0.000 01)、血清前白蛋白水平(I2=0%,95% CI=0.02~0.05,Z=3.94,P<0.000 1)显著高于常规营养支持组,C反应蛋白水平显著低于常规营养支持组(I2=76%,95% CI=-21.33~-5.03,Z=3.17,P=0.002);CD3+%(I2=0%,95% CI=-3.50~2.56,Z=0.31,P=0.76)、IgG(I2=92%,95% CI=-0.32~5.54,Z=1.74,P=0.08)、IgM(I2=99%,95% CI=-0.52~1.89,Z=1.11,P=0.27)、血清总蛋白(I2=0%,95% CI=-4.08~1.77,Z=0.78,P=0.44)、白蛋白(I2=29%,95% CI=-0.87 ~1.45,Z=0.49,P=0.63)和转铁蛋白(I2=0%,95% CI=-0.23 ~0.19,Z=0.19,P=0.85)的组间差异无统计学意义.结论 ω-3多不饱和脂肪酸可提高消化系统恶性肿瘤患者围手术期的免疫功能,减轻炎性与应激反应,但对营养状况的改善效果不明显.
目的 繫統評價添加ω-3多不飽和脂肪痠的營養支持對消化繫統噁性腫瘤患者免疫功能與營養狀況的影響.方法 檢索MEDLINE、EMBASE、Cochrane對照試驗中心註冊數據庫(CENTRAL)、中國知網(CNKI)和中國生物醫學文獻數據庫(CBM),檢索起止時間為數據庫默認時間.檢索主題詞選擇omega-3 fatty acids、fish oil、cancer、tumor、neoplasms、ω-3多不飽和脂肪痠、魚油、噁性腫瘤和癌癥.採用Jadad量錶進行研究質量評價,篩選齣高質量隨機對照試驗.採用RevMan 5.2統計軟件進行分析,研究ω-3多不飽和脂肪痠對消化繫統噁性腫瘤患者免疫和營養指標的影響.結果 共納入12項高質量隨機對照試驗.Meta分析結果顯示,ω-3多不飽和脂肪痠支持組的CD4+%(I2=0%,95% CI=3.44~6.93,Z=5.82,P<0.00001)、CD8+%(I2=0%,95%CI=2.44~7.13,Z=4.00,P<0.000 1)、CD4+%/CD8+%(I2=74%,95% CI=0.16~0.83,Z=2.87,P=0.004)、IgA(I2=14%,95% CI=0.21~0.43,Z=5.84,P<0.000 01)、血清前白蛋白水平(I2=0%,95% CI=0.02~0.05,Z=3.94,P<0.000 1)顯著高于常規營養支持組,C反應蛋白水平顯著低于常規營養支持組(I2=76%,95% CI=-21.33~-5.03,Z=3.17,P=0.002);CD3+%(I2=0%,95% CI=-3.50~2.56,Z=0.31,P=0.76)、IgG(I2=92%,95% CI=-0.32~5.54,Z=1.74,P=0.08)、IgM(I2=99%,95% CI=-0.52~1.89,Z=1.11,P=0.27)、血清總蛋白(I2=0%,95% CI=-4.08~1.77,Z=0.78,P=0.44)、白蛋白(I2=29%,95% CI=-0.87 ~1.45,Z=0.49,P=0.63)和轉鐵蛋白(I2=0%,95% CI=-0.23 ~0.19,Z=0.19,P=0.85)的組間差異無統計學意義.結論 ω-3多不飽和脂肪痠可提高消化繫統噁性腫瘤患者圍手術期的免疫功能,減輕炎性與應激反應,但對營養狀況的改善效果不明顯.
목적 계통평개첨가ω-3다불포화지방산적영양지지대소화계통악성종류환자면역공능여영양상황적영향.방법 검색MEDLINE、EMBASE、Cochrane대조시험중심주책수거고(CENTRAL)、중국지망(CNKI)화중국생물의학문헌수거고(CBM),검색기지시간위수거고묵인시간.검색주제사선택omega-3 fatty acids、fish oil、cancer、tumor、neoplasms、ω-3다불포화지방산、어유、악성종류화암증.채용Jadad량표진행연구질량평개,사선출고질량수궤대조시험.채용RevMan 5.2통계연건진행분석,연구ω-3다불포화지방산대소화계통악성종류환자면역화영양지표적영향.결과 공납입12항고질량수궤대조시험.Meta분석결과현시,ω-3다불포화지방산지지조적CD4+%(I2=0%,95% CI=3.44~6.93,Z=5.82,P<0.00001)、CD8+%(I2=0%,95%CI=2.44~7.13,Z=4.00,P<0.000 1)、CD4+%/CD8+%(I2=74%,95% CI=0.16~0.83,Z=2.87,P=0.004)、IgA(I2=14%,95% CI=0.21~0.43,Z=5.84,P<0.000 01)、혈청전백단백수평(I2=0%,95% CI=0.02~0.05,Z=3.94,P<0.000 1)현저고우상규영양지지조,C반응단백수평현저저우상규영양지지조(I2=76%,95% CI=-21.33~-5.03,Z=3.17,P=0.002);CD3+%(I2=0%,95% CI=-3.50~2.56,Z=0.31,P=0.76)、IgG(I2=92%,95% CI=-0.32~5.54,Z=1.74,P=0.08)、IgM(I2=99%,95% CI=-0.52~1.89,Z=1.11,P=0.27)、혈청총단백(I2=0%,95% CI=-4.08~1.77,Z=0.78,P=0.44)、백단백(I2=29%,95% CI=-0.87 ~1.45,Z=0.49,P=0.63)화전철단백(I2=0%,95% CI=-0.23 ~0.19,Z=0.19,P=0.85)적조간차이무통계학의의.결론 ω-3다불포화지방산가제고소화계통악성종류환자위수술기적면역공능,감경염성여응격반응,단대영양상황적개선효과불명현.
Objective To systematically review the effect of ω-polyunsaturated fatty acids-supplemented nutrition support on the immune function and nutritional status of patients with gastrointestinal malignancies.Methods Databases of MEDLINE,EMBASE,Cochrance Central register of controlled trials,China National Knowledge Infrastructure (CNKI),China Biology Medicine disc (CBM) were searched.The search words were omega-3 polyunsaturated fatty acids,fish oil,cancer,turmor,neoplasms in English or Chinese.All the high quality randomized controlled trials were included after assessed with Jadad scale.RevMan 5.2 was used for statistical analysis.Results Altogether 12 studies were included.Meta-analysis results showed that CD4+% (I2 =0%,95% CI=3.44~6.93,Z=5.82,P<0.00001),CD8+% (I2 =0%,95% CI=2.44~7.13,Z=4.00,P<0.000 1),CD4+%/CD8+% (I2 =74%,95% CI=0.16~0.83,Z=2.87,P=0.004),IgA (I2=14%,95% CI=0.21 ~0.43,Z=5.84,P<0.00001),prealbumin (I2 =0%,95%CI =0.02 ~ 0.05,Z =3.94,P < 0.000 1) in the treatment group were higher than in the control group,C-reactive protein (I2 =76%,95% CI =-21.33 ~-5.03,Z =3.17,P =0.002) in the treatment group was lower than in the control group,the differences were all statistically significant.But there were no statistically significant differences in CD3 + % (I2 =0%,95% CI =-3.50 ~ 2.56,Z =0.31,P =0.76),IgG (I2 =92%,95% CI=-0.32 ~5.54,Z=1.74,P=0.08),IgM (I2 =99%,95% CI=-0.52~1.89,Z=1.11,P=0.27),total protein (I2 =0%,95%CI=-4.08 ~1.77,Z=0.78,P=0.44),albumin (I2 =29%,95% CI=-0.87 ~1.45,Z=0.49,P=0.63),transferrin (I2 =0%,95% CI=-0.23~0.19,Z =0.19,P =0.85) between treatment and control groups.Conclusion Omega-3 polyunsaturated fatty acids can improve the perioperative immune function of patients with gastrointestinal malignant tumor,reduce inflammatory and stress reactions,but have no obvious effect on the improvement of the nutritional status.