CAJ | 학술논문

目的：观察疏肝通络方治疗糖尿病合并非酒精性脂肪肝（ NAFLD ）的临床疗效。方法将120例糖尿病合并NAFLD的患者随机分为治疗组60例、对照组60例，在控制血糖的基础上，对照组采用健康教育、改变生活方式等措施治疗，治疗组在上述基础上加用疏肝通络方口服。结果治疗组60例中，完全缓解5例（8．33％），显效31例（51．67％），有效17例（28．33％），无效7例（11.67％），总有效率为88．33％；对照组59例中，完全缓解2例（3．39％），显效12例（20．34％），有效16例（27．12％），无效29例（49．15％），总有效率为50．85％。经Ridit分析，U＝－5．122， P＜0．001，说明治疗组总体疗效优于对照组。2组中医症状积分治疗后较本组治疗前均降低（ P＜0.01），治疗组较对照组降低更明显（P＜0．05），说明治疗组优于对照组。2组ALT，AST，TG，TC， LDL-C治疗后均较本组治疗前均降低（P＜0．05，P＜0．01），治疗组ALT，AST，TG，TC，LDL-C较对照组降低明显（P＜0．05）。 BMI治疗组较治疗前降低（P＜0．01），对照组治疗前后比较差异无统计学意义（ P＞0．05）。结论疏肝通络方治疗糖尿病合并NAFLD具有较好的疗效。
목적：관찰소간통락방치료당뇨병합병비주정성지방간（ NAFLD ）적림상료효。방법장120례당뇨병합병NAFLD적환자수궤분위치료조60례、대조조60례，재공제혈당적기출상，대조조채용건강교육、개변생활방식등조시치료，치료조재상술기출상가용소간통락방구복。결과치료조60례중，완전완해5례（8．33％），현효31례（51．67％），유효17례（28．33％），무효7례（11.67％），총유효솔위88．33％；대조조59례중，완전완해2례（3．39％），현효12례（20．34％），유효16례（27．12％），무효29례（49．15％），총유효솔위50．85％。경Ridit분석，U＝－5．122， P＜0．001，설명치료조총체료효우우대조조。2조중의증상적분치료후교본조치료전균강저（ P＜0.01），치료조교대조조강저경명현（P＜0．05），설명치료조우우대조조。2조ALT，AST，TG，TC， LDL-C치료후균교본조치료전균강저（P＜0．05，P＜0．01），치료조ALT，AST，TG，TC，LDL-C교대조조강저명현（P＜0．05）。 BMI치료조교치료전강저（P＜0．01），대조조치료전후비교차이무통계학의의（ P＞0．05）。결론소간통락방치료당뇨병합병NAFLD구유교호적료효。
Objective To observe the curative effect of soothing liver for dredging collaterals formula on diabetes combined with non-alcoholic fatty liver disease ( NAFLD ) .Methods 120 patients suffering diabetes combined with NAFLD were randomly divided into treatment group ( n=60 ) and control group ( n=60) .Based on controlling of blood glucose, health education and changing life style were conducted for the control group, soothing liver for dredging collaterals formula were given to the treatment group. Results In treatment group ( n =60 ) , 5 cases got complete remission ( 8.33%) , 31 cases had significant effect ( 51.67%) , 17 cases showed effective ( 28.33%) , 7 cases were presented as ineffective (11.67%), the total effective rate was 88.33%; In control group ( n=59), 2 cases got complete remission (3.39%), 12 cases had significant effect (20.34%), 16 cases showed effective (27.12%), 29 cases were presented as ineffective (49.15%), the total effective rate was 50.85%. Ridit analyze showed U=-5.122, P<0.001, which indicated the treatment group was superior to the control group.Symptoms of Chinese medicine in both groups decreased significantly compared that before treatment (P<0.01), and treatment group decreased more than control group (P<0.05), which indi-cated treatment group was superior to control group.ALT,AST,TG,TC and LDL-C of both groups de-creased significantly compared with that before treatment (P<0.05,P<0.01), and ALT, AST, TG, TC, LDL-C of treatment group decreased more than control group (P<0.05).BMI of treatment group was significantly lower than that before treatment (P<0.01), while in control group, BMI showed no significant differences before and after treatment (P>0.05).Conclusions Soothing liver for dredging collaterals formula has good effect on diabetes combined with non-alcoholic fatty liver disease.