CAJ | 학술논문

胆道系统恶性肿瘤是消化系统较常见的恶性肿瘤.由于缺乏典型临床表现及有效的早期诊断方法,多数患者发现时已是晚期,失去了手术机会.现有的放化疗手段对胆道系统恶性肿瘤收效甚微.因此,亟需探索治疗胆道系统恶性肿瘤的新手段.人类表皮生长因子受体2(HER2)/neu基因编码蛋白是一种具有酪氨酸激酶活性的跨膜糖蛋白,在胆道系统恶性肿瘤的发生、发展和侵犯转移过程中发挥着重要作用.HER2/neu基因高表达与胆道系统恶性肿瘤患者临床病理因素及预后密切相关,有望作为肿瘤治疗的新靶点.
담도계통악성종류시소화계통교상견적악성종류.유우결핍전형림상표현급유효적조기진단방법,다수환자발현시이시만기,실거료수술궤회.현유적방화료수단대담도계통악성종류수효심미.인차,극수탐색치료담도계통악성종류적신수단.인류표피생장인자수체2(HER2)/neu기인편마단백시일충구유락안산격매활성적과막당단백,재담도계통악성종류적발생、발전화침범전이과정중발휘착중요작용.HER2/neu기인고표체여담도계통악성종류환자림상병리인소급예후밀절상관,유망작위종류치료적신파점.
Biliary tract carcinoma (BTC) is a common malignancy in human digestive system.The lethality of BTC is essentially attributed to the asymptomatic growth of BTC and the lack of effective diagnostic options.The disease is therefore usually detected at an advanced stage and lost the opportunity of surgical therapy.Conventional chemotherapy and radiation therapy have been notably ineffective against BTC.There is now a real and urgent need to focus on developing novel and potent therapeutic strategies against BTC.Human epidermal growth factor receptor 2/neu (HER2/neu) is a member of the ErbB receptor tyrosine kinase family.HER2/neu is associated with tumor proliferation,invasion,and metastasis that would impact in a significant way on clinical outcome.HER/neu may become a new therapy target of BTC.