CAJ | 학술논문

乳腺癌是源于乳腺导管上皮的恶性肿瘤，目前已成为威胁女性健康的第一大杀手。在乳腺癌发生发展过程中，伴随着许多基因和蛋白质的改变，与肿瘤相关的生物标志物的检测对乳腺癌的术前诊断、指导治疗、判断预后起着非常重要的作用。目前，常用的生物标志物主要有激素受体、原癌基因和抑癌基因、增殖与凋亡因子、侵袭和转移因子、特异性蛋白、microRNA 6类。本文将对常用的乳腺癌的生物标志物的应用及进展进行介绍，从而为乳腺癌的早期预防、早期诊断和治疗提供参考依据。
유선암시원우유선도관상피적악성종류，목전이성위위협녀성건강적제일대살수。재유선암발생발전과정중，반수착허다기인화단백질적개변，여종류상관적생물표지물적검측대유선암적술전진단、지도치료、판단예후기착비상중요적작용。목전，상용적생물표지물주요유격소수체、원암기인화억암기인、증식여조망인자、침습화전이인자、특이성단백、microRNA 6류。본문장대상용적유선암적생물표지물적응용급진전진행개소，종이위유선암적조기예방、조기진단화치료제공삼고의거。
Breast cancer is a kind ofmalignant tumor which originated from breast ductal epithelial, and it has become the largest threat to women's health at present. During the development of breast cancer, many kinds of genes and proteins have changed, and the detection of tumor markers plays a very important role in the preoperative diagnosis, guiding treatment and judging prognosis. In the current, the commonly used biomarkers in breast cancer are mainly divided into six classes: hormone receptor, proto-oncogenes and tumor suppressor genes, proliferation and apoptosis factor, invasion and metastasis factor, specific proteins, and microRNA. The applicationand development of the commonly used biomarkers in breast cancer will be introduced in this paper, so as to provide reference for early prevention, early diagnosis and treatment of breast cancer.