CAJ | 학술논문

目的：探讨H型高血压患者血清同型半胱氨酸（Hcy）及B型脑纳肽前体N端片段（NT- pro BNP）水平与舒张性心力衰竭（DHF）的相关性及意义。方法对65例H型高血压患者根据美国纽约心脏病协会（NYHA）进行分级，其中NYHA分级Ⅱ～Ⅳ级舒张性DHF患者38例（心力衰竭组），心功能正常27例（对照组）。测定患者Hcy、NT- pro BNP水平，并对不同心功能分级患者进行分析。结果心力衰竭组血清Hcy、NT- pro BNP水平为（28.24±5.90）μmol/L、（905±53.69）ng/L；对照组血清Hcy、NT- pro BNP水平为（19.26±2.38）μmol/L、（415±36.76）ng/L，差异均有统计学意义（均P＜0.05）。Hcy与NT- pro BNP呈直线相关关系，说明DHF患者的Hcy水平是引起NT- pro BNP升高的独立危险因素（P＜0.01）。结论 H型高血压患者Hcy、NT- pro BNP水平随NYHA分级增加而升高，Hcy可能是舒张性DHF患者的独立危险因素，Hcy水平可能作为预测DHF进程的重要标志物。
목적：탐토H형고혈압환자혈청동형반광안산（Hcy）급B형뇌납태전체N단편단（NT- pro BNP）수평여서장성심력쇠갈（DHF）적상관성급의의。방법대65례H형고혈압환자근거미국뉴약심장병협회（NYHA）진행분급，기중NYHA분급Ⅱ～Ⅳ급서장성DHF환자38례（심력쇠갈조），심공능정상27례（대조조）。측정환자Hcy、NT- pro BNP수평，병대불동심공능분급환자진행분석。결과심력쇠갈조혈청Hcy、NT- pro BNP수평위（28.24±5.90）μmol/L、（905±53.69）ng/L；대조조혈청Hcy、NT- pro BNP수평위（19.26±2.38）μmol/L、（415±36.76）ng/L，차이균유통계학의의（균P＜0.05）。Hcy여NT- pro BNP정직선상관관계，설명DHF환자적Hcy수평시인기NT- pro BNP승고적독립위험인소（P＜0.01）。결론 H형고혈압환자Hcy、NT- pro BNP수평수NYHA분급증가이승고，Hcy가능시서장성DHF환자적독립위험인소，Hcy수평가능작위예측DHF진정적중요표지물。
Objective To evaluate the relationship of serum homocysteine and NT- proBNP levels with diastolic car-diac failure in patients with hyperhomocysteinemia- related hypertension (H- type hypertension). Methods Sixty five patients with H- type hypertension were recruited and divided into cardiac failure group(n=38) and control group(n=27). Serum homocys-teine and NT- proBNP levels were measured and results were analyzed. Results There was a significant difference in serum homocysteine and NT- proBNP levels between cardiac failure and control groups (28.24±5.90μmol/l vs 19.26±2.38μmol/l and 905±53.69ng/l vs 415±36.76ng/l, respectively;P<0.05) . Serum homocysteine level was positively correlated with NT- proBNP (P<0.05). Conclusion There is a positive correlation between serum homocysteine and NT- proBNP levels, homocysteine may be an independent risk factor for diastolic cardiac failure in patients with H- type hypertension.